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Textbook Mosbys Diagnostic and Laboratory Test Reference Kathleen Pagana Ebook All Chapter PDF
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ROUTINE BLOOD TESTING
Many laboratory tests include the direction to perform routine blood
testing. The protocol for those tests is presented here and is cross-
referenced within the many tests requiring them.
Before
• Follow proper patient identification protocols to avoid wrong patient
events. Usually name and date of birth are used as two identifiers.
Explain the procedure to the patient.
Tell the patient if fasting is necessary. (Fasting is most commonly
required with glucose and lipid studies.)
If fasting is required, instruct the patient not to consume any food or
fluids. Only water is permitted. Fasting requirements usually vary from
8 to 12 hours.
Instruct the patient to continue taking medications unless told
otherwise by the health-care provider.
During
• Collect the blood in a properly color-coded test tube (Table A, p. xiv),
which indicates the presence or absence of additives. Tube stopper
colors may vary with different manufacturers. If uncertain, verify with
the laboratory.
After
• Apply pressure or a pressure dressing to the venipuncture site.
• Assess the site for bleeding.
= Patient teaching
ROUTINE URINE TESTING
Many laboratory tests include the direction to perform routine urine
testing. The protocol for those tests is presented here and is cross-
referenced within the many tests requiring them.
Before
• Follow proper patient identification protocols to avoid wrong patient
events. Usually, name and date of birth are used as two identifiers.
Explain the procedure to the patient.
Inform the patient if food or fluid restrictions are needed.
During
Random, fresh, or spot specimen
Instruct the patient to urinate into an appropriate nonsterile container.
24-hour specimen
1. Begin the 24-hour collection by discarding the first specimen.
2. Collect all urine voided during the next 24 hours.
3. Show the patient where to store the urine.
4. Keep the urine on ice or refrigerated during the collection period.
Foley bags are kept in a basin of ice. Some collections require a
preservative. Check with the laboratory.
5. Post the hours for the urine collection in a prominent place to prevent
accidentally discarding a specimen.
6. Instruct the patient to void before defecating so that urine is not
contaminated by stool.
7. Remind the patient not to put toilet paper in the urine collection
container.
8. Collect the last specimen as close as possible to the end of the
24-hour period. Add this urine to the collection.
After
• Transport the specimen promptly to the laboratory.
= Patient teaching
COMMON REFERENCE RANGES
FOR HEALTHY ADULTS
DIAGNOSTIC AND
LABORATORY
TEST REFERENCE
Fourteenth Edition
Previous editions copyrighted 2017, 2015, 2013, 2011, 2009, 2007, 2005, 2003,
2001, 1999, 1997, 1995, 1992
This book and the individual contributions contained in it are protected under
copyright by the Publisher (other than as may be noted herein).
Notices
Practitioners and researchers must always rely on their own experience and
knowledge in evaluating and using any information, methods, compounds
or experiments described herein. Because of rapid advances in the medical
sciences, in particular, independent verification of diagnoses and drug dosages
should be made. To the fullest extent of the law, no responsibility is assumed
by Elsevier, authors, editors or contributors for any injury and/or damage to
persons or property as a matter of products liability, negligence or otherwise,
or from any use or operation of any methods, products, instructions, or ideas
contained in the material herein.
—KDP, TJP
—TNP
reviewers
iv
preface
The 14th edition of Mosby’s Diagnostic and Laboratory Test
Reference provides the user with an up-to-date, essential refer-
ence that allows easy access to clinically relevant laboratory and
diagnostic tests. A unique feature of this handbook is its consis-
tent format, which allows for quick reference without sacrificing
the depth of detail necessary for a thorough understanding of
diagnostic and laboratory testing. All tests begin on a new page
and are listed in alphabetical order by their complete names. The
alphabetical format is a strong feature of the book; it allows the
user to locate tests quickly without first having to place them in an
appropriate category or body system. The User’s Guide to Test
Preparation and Procedures section outlines the responsibilities
of health-care providers to ensure that the tests are accurately and
safely performed. Use of this guide should eliminate the need
for test repetition resulting from problems with patient prepara-
tion, test procedures, or collection techniques. Information on
radiation exposure and risks has been added. Every feature of this
book is designed to provide pertinent information in a sequence
that best simulates priorities in the clinical setting.
The following information is provided, wherever applicable,
for effective diagnostic and laboratory testing:
• Name of test. Tests are listed by their complete names. A
complete list of abbreviations and alternate test names follows
each main entry.
• Type of test. This section identifies whether the test is, for
example, an x-ray procedure, ultrasound, nuclear scan, blood
test, urine test, sputum test, or microscopic examination of
tissue. This section helps the reader identify the source of the
laboratory specimen or location of the diagnostic procedure.
• Normal findings. Where applicable, normal values are listed for
the infant, child, adult, and elderly person. Also, where appro-
priate, values are separated into male and female. It is impor-
tant to realize that normal ranges of laboratory tests vary from
institution to institution. This variability is even more obvious
among the various laboratory textbooks. For this reason, we
have deliberately chosen not to add a table of normal values
as an appendix, and we encourage the user to check the nor-
mal values at the institution where the test is performed. This
should be relatively easy because laboratory reports include nor-
mal values. Results are given in both conventional units and the
International System of Units (SI units) where possible.
v
vi preface
• Possible critical values. These values give an indication of
results that are well outside the normal range. These results
require health-care provider notification and usually result in
some type of intervention. The Joint Commission is looking
at the timely and reliable communication of critical laboratory
values as one of its patient safety goals.
• Test explanation and related physiology. This section pro-
vides a concise yet comprehensive description of each test. It
includes fundamental information about the test itself, spe-
cific indications for the test, how the test is performed, what
disease or disorder the various results may show, how it will
affect the patient or client, and relevant pathophysiology that
will enhance understanding of the test.
• Contraindications. These data are crucial because they alert
health-care providers to patients to whom the test should
not be administered. Patients highlighted in this section fre-
quently include those who are pregnant, are allergic to iodin-
ated or contrast dyes, or have bleeding disorders.
• Potential complications. This section alerts the user to
potential problems that necessitate astute assessments and
interventions. For example, if a potential complication is renal
failure, the implication may be to hydrate the patient before
the test and force fluids after the test. A typical potential com-
plication for many x-ray procedures is allergy to iodinated dye.
Patient symptoms and appropriate interventions are described
in detail.
• Interfering factors. This section contains pertinent informa-
tion because many factors can invalidate the test or make the
test results unreliable. An important feature is the inclusion of
drugs that can interfere with test results. Drugs that increase
or decrease test values are always listed at the end of this sec-
tion for consistency and quick access. A drug symbol ( ) is
used to emphasize these drug interferences.
• Procedure and patient care. This section emphasizes the
role of nurses and other health-care providers in diagnostic
and laboratory testing by addressing psychosocial and physi-
ologic interventions. Patient teaching priorities are noted
with a special icon ( ) to highlight information to be com-
municated to patients. For quick access to essential informa-
tion, this section is divided into before, during, and after time
sequences.
◦ Before. This section addresses the need to explain the pro-
cedure and to allay patient concerns or anxieties. If patient
consent is usually required, this is listed as a bulleted item.
preface vii
Other important features include requirements such as
fasting, obtaining baseline values, and performing bowel
preparations. Radiation risk is addressed with x-rays and
nuclear medicine studies.
◦ During. This section gives specific directions for
clinical specimen studies (e.g., urine and blood stud-
ies). Diagnostic procedures and their variations are
described in a numbered, usually in a step-by-step for-
mat. Important information, such as who performs the
test, where the study is performed, patient sensation,
and duration of the procedure, is bulleted for emphasis.
The duration of the procedure is very helpful for patient
teaching because it indicates the time generally allotted
for each study.
◦ After. This section includes vital information that the
nurse or other health-care provider should heed or convey
after the test. Examples include such factors as maintaining
bed rest, comparing pulses with baseline values, encourag-
ing fluid intake, and observing the patient for signs and
symptoms of sepsis.
• Abnormal findings. As the name implies, this section lists
the abnormal findings for each study. Diseases or conditions
that may be indicated by increased ( ) or decreased ( ) val-
ues are listed where appropriate.
• Notes. This blank space at the end of the tests facilitates indi-
vidualizing the studies according to the institution at which
the test is performed. Variations in any area of the test (e.g.,
patient preparation, test procedure, normal values, postproce-
dural care) can be noted here.
This logical format emphasizes clinically relevant informa-
tion. The clarity of this format allows for quick understanding
of content essential to both students and health-care provid-
ers. Color has been used to help locate tests and to highlight
critical information (e.g., possible critical values). Color is also
used in the illustrations to enhance the reader’s understanding
of many diagnostic procedures (e.g., bronchoscopy, fetoscopy,
endoscopic retrograde cholangiopancreatography [ERCP], peri-
cardiocentesis, transesophageal echocardiography [TEE]). Many
tables are used to simplify complex material on such topics as
bioterrorism infectious agents, blood collection tubes, hepatitis
testing, and protein electrophoresis. Extensive cross-referencing
exists throughout the book, which facilitates understanding
and helps the user tie together or locate related studies, such as
hemoglobin and hematocrit.
viii preface
Standard guidelines for routine blood and urine testing are
located on the inside front cover for easy access. A list of abbre-
viations for test names is included on the book’s endpapers.
Appendix A includes a list of studies according to body system.
This list may familiarize the user with other related studies the
patient or client may need or the user may want to review. This
should be especially useful for students and health-care providers
working in specialized areas.
Appendix B provides a list of studies according to test type.
This list may help the user read and learn about similarly per-
formed tests and procedures (e.g., barium enema and barium
swallow).
Appendix C provides a list of blood tests used for disease and
organ panels.
Appendix D provides a list of symbols and units of measurement.
Finally, a comprehensive index includes the names of all tests,
their synonyms and abbreviations, and any other relevant terms
found in the tests.
New to this edition is a table of Common Reference Ranges
added to the inside front cover. This adds to the user-friendly
aspect of this book by quickly identifying common reference
ranges. This is a good starting point for students and a quick
reference for routine lab values. However, because lab values vary
from institution to institution, be sure to use the normal values
of the lab performing the test.
Many new studies, such as alpha defensin, ceramides, and
small intestinal bacterial overgrowth tests, have been added. All
other studies have been revised and updated. Outdated studies
have been eliminated.
We sincerely thank our editors for their enthusiasm and con-
tinued support. We are most grateful to the many nurses and
other health-care providers who made the first 13 editions of
this book so successful. Thank you so much. This success vali-
dated the need for a user-friendly and quick-reference approach
to laboratory and diagnostic testing.
We sincerely invite additional comments from current users
of this book so that we may continue to provide useful, relevant
diagnostic and laboratory test information to users of future
editions.
Kathleen D. Pagana
Timothy J. Pagana
Theresa N. Pagana
contents
Routine blood testing, inside front cover
List of figures, x
Appendices
Appendix A: List of tests by body system, 988
Appendix B: List of tests by type, 1000
Appendix C: Disease and organ panels, 1011
Appendix D: Symbols and units of measurement, 1015
Bibliography, 1017
Index, 1019
ix
list of figures
Figure 1 Ultrasound of the abdomen, 2
Figure 2 Amniocentesis, 53
Figure 3 Immunofluorescent staining of antinuclear antibodies, 88
Figure 4 Arthroscopy, 122
Figure 5 Bilirubin metabolism and excretion, 138
Figure 6 Bone marrow aspiration, 163
Figure 7 Bronchoscopy, 185
Figure 8 Cardiac catheterization, 204
Figure 9 Chorionic villus sampling, 242
Figure 10 Hemostasis and fibrinolysis, 251
Figure 11 Colposcopy, 262
Figure 12 Cardiac enzymes after myocardial infarction, 298
Figure 13 Cystoscopic examination of the male bladder, 309
Figure 14 Ureteral catheterization through the cystoscope, 310
Figure 15 Disseminated intravascular coagulation, 331
Figure 16 Ductoscopy, 337
Figure 17 ECG planes of reference, 343
Figure 18 Electrocardiography, 344
Figure 19 Endoscopic retrograde cholangiopancreatography, 366
Figure 20 Esophageal function studies, 380
Figure 21 Fetoscopy, 420
Figure 22 Glucose tolerance test, 468
Figure 23 Hematocrit, 486
Figure 24 Holter monitoring, 510
Figure 25 Hysteroscopy, 533
Figure 26 Liver biopsy, 571
Figure 27 Lumbar puncture, 581
Figure 28 Transbronchial needle biopsy, 585
Figure 29 Stereotactic breast biopsy, 607
Figure 30 Oximetry, 659
Figure 31 Papanicolaou (Pap) smear, 669
Figure 32 Paracentesis, 672
Figure 33 Pericardiocentesis, 690
Figure 34 Rectal ultrasonography, 741
Figure 35 Lung volumes and capacities, 760
Figure 36 Renal biopsy, 777
Figure 37 Renovascular hypertension, 784
Figure 38 Rectal culture of the female, 816
Figure 39 Urethral culture of the male, 817
Figure 40 Thoracentesis, 865
Figure 41 Fibrin clot formation, 875
Figure 42 Transesophageal echocardiography, 904
x
user’s guide to test preparation and procedures
Health-care economics demands that laboratory and d iagnostic
testing be performed accurately and in the least amount of
time possible. Tests should not have to be repeated because of
improper patient preparation, test procedure, or specimen col-
lection technique. Patient identification protocols should be fol-
lowed to avoid wrong patient events. Two patient identifiers,
such as name and date of birth, are usually used. The following
guidelines delineate the responsibilities of health-care providers
to ensure safety of test procedures and accuracy of test results.
Guidelines are described for the following major types of tests:
blood, urine, stool, x-ray, nuclear scanning, ultrasound, and
endoscopy.
Blood tests
Overview
Blood studies are used to assess a multitude of body processes
and disorders. Common studies include enzymes, serum lipids,
electrolyte levels, red and white blood cell counts, clotting fac-
tors, hormone levels, and levels of breakdown products (e.g.,
blood urea nitrogen).
Multiphasic screening machines can perform many blood tests
simultaneously using a very small blood sample. The advantages
of using these machines are that results are available quickly and
the cost is lower when compared with individually performing
each test.
Appendix C provides a list of current disease and organ
panels. For example, the basic metabolic panel and the com-
prehensive metabolic panel have replaced the Chem-7 and
Chem-12 panels. These changes are the result of federal
guidelines that have standardized the nomenclature for chem-
istry panels.
Guidelines
• Observe universal precautions when collecting a blood specimen.
• Check whether fasting is required. Many studies, such as fast-
ing blood sugar and cholesterol levels, require fasting for a
designated period of time. Water is permitted.
• If ordered, withhold medications until the blood is drawn.
• Record the time of day when the blood test is drawn. Some
blood test results (e.g., those for cortisol) vary according to
a diurnal pattern, and this must be considered when blood
levels are interpreted.
xi
xii user’s guide to test preparation and procedures
• In general, two or three blood tests can be done per tube of
blood collected (e.g., two or three chemistry tests from one
red-top tube of blood).
• Note the patient’s position for certain tests (e.g., renin,
because levels are affected by body position).
• Collect the blood in a properly color-coded test tube. Blood
collection tubes have color-coded stoppers to indicate the
presence or absence of different types of additives (preserva-
tives and anticoagulants). A preservative prevents change in
the specimen, and an anticoagulant inhibits clot formation or
coagulation. Charts are available from the laboratory indicat-
ing the type of tube needed for each particular blood test. A
representative chart is shown in Table A, p. xiv.
• Follow the recommended order of draw when collecting
blood in tubes. Draw specimens into nonadditive (e.g., red-
top) tubes before drawing them into tubes with additives.
This prevents contamination of the blood specimen with
additives that may cause incorrect test results. Fill the tubes in
the following order:
1. Blood culture tubes (to maintain sterility)
2. Nonadditive tubes (e.g., red-top)
3. Coagulation tubes (e.g., blue-top)
4. Heparin tubes (e.g., green-top)
5. Ethylenediaminetetraacetic acid (EDTA) tubes (e.g.,
lavender-top)
6. Oxalate/fluoride tubes (e.g., gray-top)
• To obtain valid results, do not fasten the tourniquet for lon-
ger than 1 minute. Prolonged tourniquet application can
cause stasis and hemoconcentration.
• Collect the blood specimen from the arm without an intra-
venous (IV) device, if possible. IV infusion can influence test
results.
• Do not use the arm bearing a dialysis arteriovenous fistula for
venipuncture unless the physician specifically authorizes it.
• Because of the risk of cellulitis, do not take specimens from
the side on which a mastectomy or axillary lymph node dissec-
tion was performed.
• Follow the unit guidelines for drawing blood from an indwell-
ing venous catheter (e.g., a triple-lumen catheter). Guidelines
will specify the amount of blood to be drawn from the cath-
eter and discarded before blood is collected for laboratory
studies. The guidelines will also indicate the amount and type
of solution needed to flush the catheter after drawing the
blood to prevent clotting.
TABLE A Common blood collection tubes
Stool tests
Overview
The examination of feces provides important information that
aids in the differential diagnosis of various gastrointestinal dis-
orders. Fecal studies may also be used for microbiologic studies,
chemical determinations, and parasitic examinations.
Guidelines
• Observe universal precautions in collecting a stool specimen.
• Collect stool specimens in a clean container with a fitted lid.
• Do not mix urine and toilet paper with the stool specimen.
Both can contaminate the specimen and alter the results.
• Fecal analysis for occult blood, white blood cells, or qualita-
tive fecal fat requires only a small amount of a randomly col-
lected specimen.
• Quantitative tests for daily fecal excretion of a particular sub-
stance require a minimum of a 3-day fecal collection. This col-
lection is necessary because the daily excretion of feces does
not correlate well with the amount of food ingested by the
patient in the same 24-hour period. Refrigerate specimens or
keep them on ice during the collection period. Collect stool
in a 1-gallon container.
• A small amount of fecal blood that is not visually apparent is
termed occult blood. Chemical tests using commercially pre-
pared slides are routinely used to detect fecal blood. Numerous
commercial slide tests use guaiac as the indicator. These guaiac
tests are routinely done on nursing units and in medical offices.
• Consider various factors (e.g., other diagnostic tests and
medications) in planning the stool collection. For example, if
the patient is scheduled for x-ray studies with barium sulfate,
collect the stool specimen first. Various medications (e.g., tet-
racyclines and antidiarrheal preparations) affect the detection
of intestinal parasites.
• Some fecal collections require dietary restrictions before the
collection (e.g., tests for occult blood).
• Correctly label and deliver stool specimens to the laboratory
within 30 minutes after collection. If you are unable to deliver
the specimen within 30 minutes, it may be refrigerated for up
to 2 hours.
X-ray studies
Overview
Because of the ability of x-rays to penetrate tissues, x-ray stud-
ies provide a valuable picture of body structures. X-ray studies
can be as simple as a routine chest x-ray image or as complex as
user’s guide to test preparation and procedures xvii
dye-enhanced cardiac catheterization. With the concern about
radiation exposure, it is important to realize that the patient may
question if the proposed benefits outweigh the risks involved.
Radiation dose
There are several units used to quantify amount of radia-
tion absorbed from diagnostic imaging tests. The gray (Gy) is
the measure of the amount of energy absorbed per unit mass.
Because different organs in the body absorb radiation differently,
the sievert (Sv) is often used instead of the gray. The sievert is
the biological effect of 1 gray of radiation on human body tis-
sue. The sievert is more helpful in comparing radiation exposure
to different parts of the body. Radiation doses in medical imag-
ing are typically measured in millisieverts (mSv) or 1/1000 of a
sievert. On average, each person receives about 3 mSv of radia-
tion yearly from natural background radiation.
The roentgen equivalent in man (rem) is an older unit to
quantify the amount of radiation absorbed from x-rays. 1 rem is
equivalent to 0.01 sievert.
See chart below for average amounts of radiation for adults
associated with diagnostic testing.
Risk of radiation
Radiation exposure can cause damage to DNA. The body usu-
ally rapidly repairs this damage. Mistakes in DNA repair can lead
to chromosomal or gene abnormalities that may be linked to
cancer induction. The likelihood of cancer induction secondary
to radiation exposure increases as the amount of radiation expo-
sure increases. A person has a 5% increase in developing cancer
over his or her lifetime after radiation exposure of 1 Sv or more.
There can be a lag of many years between radiation exposure
and cancer diagnosis. The average lag time is about 10 years
after exposure.
The cumulative radiation dose from diagnostic imaging is very
small and the benefit of proper diagnosis and treatment of disease
generally outweighs the risks. However each patient’s current sit-
uation and history of radiation must be considered to accurately
assess cumulative risks and benefits. Diagnostic procedures with
higher radiation doses (e.g., computed tomography [CT] scans)
should be clearly justified. Appropriateness Criteria published by
the American College of Radiology (acr.org) is helpful in justifi-
cation of performance of x-ray imaging.
Special consideration should be given to pregnant women
and children before ordering x-ray imaging because the effects
of radiation are more profound in fetuses and young children.
xviii user’s guide to test preparation and procedures
If a woman is pregnant, the risks versus benefits must be care-
fully considered. Certain studies with low radiation in which the
focus of radiation is not on the fetus are obviously safer. (Lead-
containing shields can reduce x-ray exposure to fetuses.) Imaging
using higher dose of radiation should be given only if the risk of
not making the diagnosis is greater than the radiation risk.
Radiation risks are most significant in early fetal period and
are less significant as the pregnancy progresses.
Patients with high body mass indexes should also be given
extra consideration before ordering imaging studies. These
patients often require greater radiation doses to penetrate body
thickness to create acceptable images. Nuclear medicines studies
are not affected in the same way. Although the x-ray exposure
needed to produce one fluoroscopic image is low (compared
with radiography), high exposures to patients can result from the
time that may be encountered in fluoroscopic procedures.
Radiation Associated with Diagnostic Testing
Common CT imaging
Abdomen and pelvis 10
Brain (head) 2
Chest 7
Chest (low-dose screening) 2
Coronary angiography 15
CT angiography of the chest 15
Neck 3
Sinuses 0.6
Spine 6
Virtual colonoscopy 10
Nuclear medicine
Bone scan 5
Brain scan 6.9
Cardiac nuclear stress testing 20-40
Gastric emptying scan 0.4
GI bleeding scan 7.8
Liver scan 3.1
Lung scan 2
(ventilation/perfusion)
Parathyroid scan 6.7
Renal scan 2.6
Thyroid scan 4.8
Urea breath test 0.003
WBC scan 6.7
Other
Abdominal angiogram 12
Cardiac catheterization (diagnostic) 7
Coronary angiogram (stent) 15
Endoscopic retrograde 4
cholangiopancreatography (ERCP)
Fluoroscopic Barium Swallow 1.5
Head and neck angiogram 5
Positron emission tomography 25
(PET)/CT
Pulmonary angiography 5
Effective doses are given as an average, and there may be wide variability in
a
Language: English
CONTENTS
INTRODUCTORY v
CHAPTER I
THE CAREFULLY LAID SCHEME 1
CHAPTER II
THE MANY-TRACKED LINES OF GERMAN DIPLOMACY 15
CHAPTER III
THE PLAN AND ITS EXECUTION 27
CHAPTER IV
FORCING THE QUARREL 40
CHAPTER V
GERMANY’S PROGRAMME 69
CHAPTER VI
THE POSITION OF ITALY 78
CHAPTER VII
THE TWELFTH HOUR 98
CHAPTER VIII
THE EARTHQUAKE 127
CHAPTER IX
BRITISH NEUTRALITY AND BELLIGERENCY 141
CHAPTER X
THE INFAMOUS OFFER 154
CHAPTER XI
JUST FOR “A SCRAP OF PAPER” 177
APPENDIX
DIPLOMACY AND THE WAR 205
Photo: Elliott & Fry
Dr. E. J. DILLON
A SCRAP of PAPER
THE INNER HISTORY OF
GERMAN DIPLOMACY
AND HER SCHEME OF
WORLD-WIDE CONQUEST
By
Dr. E. J. DILLON
Third Edition.