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JOM 2007 22 1 06 Taking The Cure - Hidden in Plain Sight The Pioneering
JOM 2007 22 1 06 Taking The Cure - Hidden in Plain Sight The Pioneering
Some physicians would stand by and see their patient die rather than use ascorbic
acid because in their finite minds it exists only as a vitamin. –F. R. Klenner, MD
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Journal of Orthomolecular Medicine Vol. 22, No. 1, 2007
‘It might be interesting to learn how driven. The sicker the patient, the higher
poliomyelitis was treated in Reidsville, the dose. Massive ascorbate treatment
N.C., during the 1948 epidemic. In the past cured every one of 60 polio cases Klenner
seven years, virus infections have been saw. He published his report in Southern
treated and cured in a period of seventy- Medicine and Surgery in July of 1949.7 All
two hours by the employment of massive patients were well in three days. None had
frequent injections of ascorbic acid, or any paralysis.
vitamin C. I believe that if vitamin C in In a 1950 letter, Klenner wrote: “Since
these massive doses–6,000 to 20,000 mg my last communication, I have seen four
in a twenty-four hour period–is given to new cases of poliomyelitis. All of these have
these patients with poliomyelitis none will completely recovered. Three cases were
be paralyzed and there will be no further seen in the acute febrile stage and in each
maiming or epidemics of poliomyelitis.’ instance, using 65 mg per kg body weight
Levy concludes: “The four doctors who (by injection) every two (to) four hours,
commented after Klenner did not have recovery was spontaneous in 48 hours.”8
anything to say about his assertions.”5 In 1951, “In an especially incredible
“How then,” asks Landwehr, “could a case,” Levy says, “Klenner9 described a
Dr. Fred R. Klenner, a virtually unknown five-year-old girl stricken with polio. This
general practitioner specializing in dis- child had already been paralyzed in both
eases of the chest, from a town no one her lower legs for over four days! The
ever heard of, with no national credentials, right leg was completely limp, and the
no research grants and no experimental left leg was determined to be 85% flaccid.
laboratory, have the nerve to make his Pain was noticed especially in the knee
sweeping claim in front of that presti- and lumbar areas. Four consulting physi-
gious body of polio authorities?” Indeed, cians confirmed the diagnosis of polio.
Klenner was hardly a man to mince words. Other than massage, vitamin C was the
“When proper amounts are used, it will only therapy initiated. After four days of
destroy all virus organisms,” he would say. vitamin C injections the child was again
“Don’t expect control of a virus with 100 moving both legs, but with only very slow
to 400 mg of C.”6 and deliberate movement. Klenner also
Klenner administered ascorbate noted that there was a ‘definite response’
by injection, and, as Lendon H. Smith after only the first injection of vitamin C.
describes in great detail in the Clinical The child was discharged from the hos-
Guide to the Use of Vitamin C: The Clini- pital after four days, and 1,000 mg of oral
cal Experiences of Frederick R. Klenner, vitamin C was continued every two hours
M.D., Klenner found that “the most ef- with fruit juice for seven days. The child
fective route was intravenous, but the was walking about, although slowly, on the
intramuscular route was satisfactory. He 11th day of treatment. By the 19th day of
gave at least 350 mg per kilogram of body treatment there was a ‘complete return of
weight.” That quantity per day is a dose of sensory and motor function,’ and no long-
25,000-30,000 mg or so for an adult. Yet, term impairment ever resulted. Vitamin
Smith adds, “With 350 mg per kilogram C not only completely cured this case of
of body weight every two hours, he could polio, it completely reversed what would
stop measles and dry up chicken pox.” undoubtedly have been a devastating, crip-
This is indeed a large amount of vita- pling result for the remainder of this girl’s
min C. Such use exemplifies the modern life.”4 For such elegant results, in the days
orthomolecular physician. Klenner’s doses before widespread use of either antibiot-
were enormous, flexible and symptom- ics or vaccination, one may wonder why
32
Hidden In Plain Sight: The Pioneering Work of Frederick Robert Klenner, M.D.
Klenner was not awarded the Nobel Prize resistance to disease and stress and with
for Medicine. a prolonged life span.” Stone adds, “I was
sorry to hear that the book you intend to
Orthomolecular Originator write is still only a gleam in your eye.”13
Born 22 October 1907 in Johnstown, Although he never would publish
Pennsylvania, Frederick Robert Klenner a book on vitamin therapy, Dr. Klenner
earned his undergraduate and graduate was a Fellow of the American College of
degrees in biology, magna cum laude, from Chest Physicians, the American College
St. Vincent and St. Francis Colleges. After of Angiology, the American Association
two teaching fellowships, he entered Duke for the Advancement of Science, and one
University School of Medicine. There, while of the founders of the American Geri-
he was ill, he met his future wife, Annie atrics Society. He was inducted into the
Hill Sharp (born February, 19, 1914), then Orthomolecular Medicine Hall of Fame
a senior nursing student who “helped in 2005.14
nurse him back to health, and romance Greensboro Daily News reporter
blossomed.”10 At the time, Annie would be Flontina Miller has colorfully described
only the second woman in the school’s his- Klenner’s office, above a drug store in
tory to graduate with a bachelor of science Reidsville. “Up a creaking stairway is a
degree. Klenner received his M.D. in 1936, dimly-lighted hallway... On one side of
and “The couple settled in Winston-Salem, the hall is a stark waiting room nearly
where Dr. Klenner was completing his filled with patients... A hand-printed sign
residency at the North Carolina Tubercu- tacked by the door reads, ‘Limited General
losis Sanitarium.”10 There, according to a Practice’...Two walls (are) covered with
short biography published in the Journal of framed certificates and honors awarded
Applied Nutrition, he “served three years by medical schools and organizations. A
in post-graduate hospital training before crude hand-scrawled cardboard sign on a
embarking on a private practice. Although window air-conditioning unit reads, ‘Snake
specializing in diseases of the chest, he Inside.’ No snake actually lives inside the
continued to do general practice because air conditioner, but Mrs. Klenner declares
of the opportunities it afforded for obser- the sign has worked miracles to keep visi-
vations in medicine. His patients were as tors’ hands off. She said patients, waiting
enthusiastic as he in playing ‘guinea pigs’ to talk with the doctor, often would tam-
to study the action of ascorbic acid.”11 per with the unit, causing continual need
Klenner had hospital privileges at for repairs... For the past 12 years, Mrs.
Reidsville’s Annie Penn Memorial Hospital Klenner has been her husband’s fulltime
where, among other things, he delivered nurse, and they manage the office with no
hundreds of babies. Given supplemental other help. ‘I’d never see my husband if I
ascorbate, not merely from birth but didn’t work with him,’ said Mrs. Klenner.
also all throughout gestation, Klenner’s . . ‘Sometimes he overworks and feels
uniformly healthy, trouble-free infants kind of tired.”15 He was also subject to
were known by the staff as the “Vitamin severe headaches, including migraines.
C Babies.”12 Still, according to journalist Jerry Bledsoe,
In a 1978 letter to Klenner, Irwin Stone Klenner never sent bills to his patients. “If
writes that he thinks that “giving levels of a patient couldn’t pay when treated, then
ascorbate for long periods of time at the he could pay when he could. And even if
daily levels you recommend... is equiva- he couldn’t pay and still needed a doctor,
lent to creating a new human subspecies, Dr. Klenner would be there, making house
“Homo sapiens ascorbicus”... with unusual calls no matter the hour.”16
33
Journal of Orthomolecular Medicine Vol. 22, No. 1, 2007
34
Hidden In Plain Sight: The Pioneering Work of Frederick Robert Klenner, M.D.
Ascorbic Acid (C): Ten to twenty grams Amino acetic acid: one heaping table-
should be taken daily by mouth in divided spoon in a glass of milk, four times each
doses. day. Naturally, the full schedule will afford
Riboflavin (Vitamin B2): 40 mg to 80 mg more dramatic response.” He declares:
given daily by needle I.M. 25 mg before “We categorically make this statement:
meals and bed time. Any victim of multiple sclerosis who will
Choline: 700 mg to 1,400 mg after each dramatically flush with the use of nico-
meal and at bed hour. tinic acid, and who has not yet progressed
Lecithin: 1,200 mg soybean lecithin after to the stage of myelin degeneration, as
each meal. witnessed by sustained ankle clonus elic-
Magnesium: 100 mg after each meal. ited in the orthodox manner, can be cured
Calcium gluconate: Two 10 grain tablets with the adequate employment of thiamin
after each meal and at bed hour. hydrochloride and other factors of the
Calcium panthothenate: 200 mg after each vitamin B complex in conjunction with
meal and at bed hour. essential proteins, lipids, carbohydrates
Aminoacetic acid (glycine): One heaping and injectable crude liver.”27
tablespoon of the powder in a glass of
milk four times each day. Media Muckraking
Zinc gluconate: 10 mg three times each Perhaps it is not a complete surprise
day has some value in Myasthenia Gravis. that the print and broadcast media have
Take several hours after vitamin B2. been obsessively interested in the scandal
Additionally, Klenner gave vitamin E that rocked Klenner’s family following
(800 to 1,600 IU/day), crude liver extract, the doctor’s death from heart disease in
adenosine-5-monophosphoric acid, and a 1984. Fred Klenner Jr., known as Fritz,
multi-vitamin/ multi-trace-mineral tablet, implicated in the murders of at least five
which would have included some vitamin people, died by his own hand in 1985.29 The
D. Klenner prescribed a high protein diet, tragedy was the subject of a bestselling
and used available drugs to relieve tremor 1988 tell-all book,30 in which Dr. Klenner
and stiffness. He might also specify lino- is mentioned over 50 times, and then, in
lenic acid, thyroid, fresh green vegetables, 1994, a 3 1/2 hour made-for-TV movie.31 It
fresh fruits, a considerable quantity of is instructive to note that the news media
milk (1 quart/day) and eggs (up to 6/day). reported on the son’s crimes far more than
Klenner required patients to limit fats, eat it reported on the father’s cures. There
only whole grain bread, and specified “no have been countless television programs
junk foods, especially sweets.”28 and Hollywood films about crime, but
Klenner also offered what he consid- not one ever made about the life-saving
ered to be an abbreviated, compromise achievements of megavitamin therapy.
program. “Should a given patient’s physi- Perhaps that is an even greater tragedy.
cian refuse to administer this schedule, “We’ve used massive doses of vitamins
I have this recommendation: One gram on over 10,000 people over a period of 30
thiamin hydrochloride one hour before years,” said Dr. Klenner, “and we’ve never
meals and at bed hour, and during the seen any ill effects from them. The only
night if awake. Niacin taken at the same effects we’ve seen have been beneficial.”
time, and in amounts sufficient to produce Dr. Klenner’s immensely valuable
a good body flush. Two hundred mg cal- work is his legacy. Linus Pauling said,
cium pantothenate and 100 mg pyridoxine “The early papers by Dr. Fred R. Klenner
before meals and at bed hour. Ten grams provide much information about the use
ascorbic acid, taken in divided doses. of large doses of vitamin C in preventing
35
Journal of Orthomolecular Medicine Vol. 22, No. 1, 2007
and treating many diseases. These papers C. Southern Med J, 1949; 3/7: 209-214.
are still important.”32 Klenner is justly re- Note: Available online at: www.orthomed.
membered as the doctor who was first to com/polio.htm and http://www.seanet.com/
%7Ealexs/ascorbate/194x/klenner-fr-south-
boldly assert that “Ascorbic acid is the saf- ern_med_surg-1949-v111-n7-p209.htm
est and most valuable substance available 8. Klenner FR: Letter to M.G. Farnsworth, Farn-
to the physician” and that patients should sworth Laboratories, Inc., Chicago, dated
be given “large doses of vitamin C in all October 14, 1950. NB: Photocopy in author’s
pathological conditions while the physi- possession.
cian ponders the diagnosis.” Whether 9. Klenner FR: Massive doses of vitamin C and
the virus diseases. South Med J. 1951; 113(4):
overshadowed by scandal or stubbornly 101-7. Note: Available online at:www.seanet.
ignored by the medical profession, high- com/~alexs/ascorbate/195x/klenner-fr-
dose ascorbate therapy is here to stay. southern_med_surg-1951-v103-n4-p101.htm
“I have used Dr. Klenner’s methods on 10. Bledsoe J. Bitter Blood: A True Story of South-
hundreds of patients,” said Lendon H. ern family Pride, Madness, and Multiple
Smith. “He is right.” Murder. NY: Dutton, 1988. Also: NY: New
American Library, 1989; 114.
11. Klenner FR: Observations on the dose of ad-
References and Notes ministration of ascorbic acid when employed
1. Saul AW, Claus Washington Jungeblut, M.D.: Po- beyond the range of a vitamin in human
lio pioneer; ascorbate advocate. J Orthomol Med, pathology. J Applied Nutr, 1971; l 23(3&4): 61-
2006; 21(2): 102-106. Note: Available online at: 68. Note: Available online at: www.orthomed.
www.doctoryourself.com/jungeblut.html com/klenner.htm and http://www.doctoryour-
2. Saul AW: The pioneering work of William self.com/klennerpaper.html
J. McCormick, MD. J Orthomol Med, 2003; 12. Stone I. The Healing Factor: Vitamin C against
18(2): 93-96. Note: Available online at: www. Disease. NY: Grosset and Dunlap, 1972; p
doctoryourself.com/mccormick.html 191-192.
3. Landwehr R: The origin of the 42-year stone- 13. Letter from Irwin Stone to Dr. & Mrs. Frederick
wall of vitamin C. J Orthomol Med, 1991: 6(2): R. Klenner, Gilmer Street, Reidsville, North
99-103. Note: Available online at: http://www. Carolina, dated 3 June 1978. NB: Carbon copy
seanet.com/~alexs/ascorbate/199x/land- kindly provided by Steve Stone. The house
wehr-r-j_orthomol_med-1991-v6-n2-p99. that was the Klenners’ longtime residence is
htm less than 20 miles north of Greensboro, NC,
4. Klenner FR: Virus pneumonia and its treat- about four miles west of US Highway 29, and
ment with vitamin C. Southern Med Surg, 1948; five blocks north of the Annie Penn Memo-
110/2: 36-38, 46. Note: Available online at:www. rial Hospital.
seanet.com/%7Ealexs/ascorbate/194x/klenner- 14. Saul AW: The 2005 Orthomolecular Medicine
fr-southern_med_surg-1948-v110-n2-p36.htm Hall of Fame. J Orthomol Med, 2005; 20(2):
5. Levy TE: Vitamin C, Infectious Diseases, and 113- 117. Note: Available online at: http://or-
Toxins: Curing the incurable. Philadelphia, thomolecular.org/hof/index.shtml.
PA: Xlibris Corporation, 2002, p 52-53. Note:: 15. Miller F: Klenner’s office recalls old-fashioned
Previously reviewed in the J Orthomol Med, practitioner. Greensboro Daily News, undated
2003; 18(2): 117-118. reprint. Note: This medium-circulation news-
6. Smith LH: Clinical Guide to the Use of Vita- paper, founded in 1909, has been known since
min C: The Clinical Experiences of Frederick 1982 as the News-Record. The periodical’s
R. Klenner, MD. Portland, OR: Life Sciences archives are accessible at http://company.
Press, 1988. Note: Originally titled: Vitamin news-record.com/library.htm .
C as a Fundamental Medicine: Abstracts of 16. Bledsoe J: 231.
Dr. Frederick R. Klenner, M.D.’s published 17. Miller F: Dr. Klenner urges taking vitamins
and unpublished work. Reprinted 1991.The in huge doses. Greensboro Daily News, 1977;
full text of this book is posted at http://www. (12)13: A8-A10.
seanet.com/~alexs/ascorbate/198x/smith-lh- 18. Klenner FR. A new office procedure for the
clinical_guide_1988.htm . determination of plasma levels for ascorbic
7. Klenner FR: The treatment of poliomyeli- acid. Tri-State Medical J, 1956(2): 26-28.
tis and other virus diseases with vitamin 19. Klenner FR: The history of lockjaw. Tri-State
36
Hidden In Plain Sight: The Pioneering Work of Frederick Robert Klenner, M.D.
37
Journal of Orthomolecular Medicine Vol. 22, No. 1, 2007
gravis and multiple sclerosis. Southern Med ministration of ascorbic acid when employed
Surgery, 1949; 11(9). beyond the range of a vitamin in human pa-
Klenner FR: The use of vitamin C as an antibiotic. thology. J Appl Nutr, 1971; 23(3&4): 60-89.
J Applied Nutr, 1953; 6: 274-278. Klenner FR: Significance of high daily intake
Also may have appeared in 1953; Southern of ascorbic acid in preventive medicine. J
Med Surg, 1953; 114(8). http://www.seanet. Int Acad Prev Med, 1974; 1:1, 45-69. Also: In
com/~alexs/ascorbate/195x/klenner-fr- Williams RJ, Kalita DK, editors. A Physician’s
j_appl_nutr-1953-v6-p274.htm and http:// Handbook on Orthomolecular Medicine. 1977.
whale.to/v/c/klenner1.html New York: Pergamon, Reprinted 1979: New
Klenner FR: A critical analysis of the Francis Canaan CT: Keats. ISBN-10: 0879831995;
report concerning the 1954 poliomyelitis vac- ISBN-13: 978-0879831998.
cine program. Tri-State Med J, 1955; (6)
Klenner FR: Poliomyelitis vaccine: Brodie vs. Publications attributed to Frederick R.
Salk, Tri-State Med J, 1955; (7) Klenner include:
Klenner FR: The role of ascorbic acid in Klenner FR: Paper presented at the 52nd Annual
therapeutics. (Letter) Tri-State Med J, 1955; Meeting of the Tri-State Medical Association
11: 34. of the Carolinas and Virginia, held in Colum-
Klenner FR: Poliomyelitis: Case histories. Tri- bia, Feb 19th and 20, 1951. May have been
State Med J, 1956; (9): 28-31. published in J Applied Nutr.
Klenner FR: An insidious virus. Tri-State Med Klenner FR: News about diabetes mellitus (let-
J, 1957; (6). ter). Tri-State Med J, 1955, May.
The folly in the continued use of a killed polio Klenner FR. Poliomyelitis vaccine: The authori-
virus vaccine. Tri-State Med J, 1959; (2): 1-8. ties speak. Tri-State Med J, 1956, March.
Klenner FR: Encephalitis as a sequelae of the Klenner may also have published in Tri-State Med J
pneumonias. Tri-State Med J, 1960; (2): 7-11. in April, 1954 and again in October, 1958.
Klenner FR: Observations on the dose and ad-
38