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Rehabilitation Practice

P a t t e r n s fo r P a t i e n t s w i t h
H e a r t Fa i l u re: The Asian Perspective
Xing-Guo Sun, MDa,b,*

KEYWORDS
 Chronic heart failure  Cardiac rehabilitation  Exercise  Taiji  Qigong  Yoga  China  Japan

KEY POINTS
 More and more countries around world have begun to use cardiac rehabilitation in patients diag-
nosed with chronic heart failure (HF).
 Asia is the largest continent in the world and, depending on its economy, culture, and beliefs, a
given Asian country differs from Western countries as well as others in Asia.
 The cardiac rehabilitation practice patterns for patients with HF are somewhat different in Asia. In
addition to the formal pattern of Western practice, it also includes the special techniques and skills,
such as Taiji, Qigong, and Yoga.
 However, these novel approaches are without regular design and strict monitoring for patients of
HF and thus further research in the field.

INTRODUCTION perspective, the increasing prevalence of HF is,


however, universal as is the diminished quality of
Chronic heart failure (HF) is a common and life (QOL)4–6 and significant increase in morbidity
disabling syndrome that is a common final and mortality associated with this condition.
pathway for several cardiac conditions. Symp- Currently, the lifetime risk of developing HF is 1
toms of HF include reductions in physical function in 5 beginning at the age of 40.7
and increased dyspnea and fatigue.1 This chronic Asia is the largest continent in the world, occu-
cardiac condition oftentimes accelerates decon- pying an area of 4400 square kilometers, account-
ditioning and the consequent vicious cycle of ing for 29.4% of global land area, with a total
numerous associated disorders.2 Extracardiac population exceeding 4 billion, accounting for
abnormalities and comorbidities, such as hyper- about two-thirds of the world’s total population.
tension, atrial fibrillation, diabetes, renal or pulmo- Asia has 48 countries and areas, and most of
nary disease, anemia, obesity, and physical them are developing countries. Their national
inactivity, may increase the risk of HF. HF is a medical standards are generally associated with
global epidemic, but clinical characteristics and their economic level and cultural background. Ac-
treatment may vary for this chronic disease popu- cording to differences in economics and cultures,
lation across geographic regions.3 From a global

Disclosures: None.
a
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases,
heartfailure.theclinics.com

Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Xicheng District,
Beijing 100037, People’s Republic of China; b Respiratory and Critical Care Physiology and Medicine, Depart-
ment of Medicine, St. John’s Cardiovascular Research Center, Harbor-UCLA Medical Center, 1124 West Carson
Street, RB2, Box 405, Torrance, CA 90502, USA
* State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases,
Chinese Academy of Medical Sciences, Peking Union Medical College, 167 Beilishi Road, Xicheng District,
Beijing 100037, People’s Republic of China.
E-mail address: xgsun@labiomed.org

Heart Failure Clin 11 (2015) 95–104


http://dx.doi.org/10.1016/j.hfc.2014.09.001
1551-7136/15/$ – see front matter Ó 2015 Elsevier Inc. All rights reserved.
96 Sun

Asia can be roughly divided into 4 different National Health Promotion Strategies. Convened
regions: the first one is developed countries repre- in 1978, the Japanese Association of CR (JACR),
sented by Japan. The second is the advanced which was preceded by the CR Research Confer-
developing countries or regions, such as Sin- ence in 1955, ushered in a new era of CR in Japan,
gapore, South Korea, Hong Kong, Macao, and a framework similar to programs seen in Western
Taiwan. The third is the larger population devel- countries.
oping countries represented by China and India. CR became an intervention covered by health
The fourth is the others, which include South, insurance in 1988, but just for those suffering an
Southeast, Mid, North, and West Asian areas and acute myocardial infarction (AMI). Since 1996,
countries, predominantly in less developed or CR is covered by Japan’s public health insurance
developing countries. system for AMI, angina pectoris, and HF. Patients
With economic development, a gradually west- undergoing a percutaneous coronary intervention
ernized lifestyle, and urbanization, risk factors for or coronary artery bypass graft surgery became
cardiovascular disease (CVD) are also on the rise covered for CR in 2004.13
in all areas of Asia. As announced at the Chinese According to data from the Japanese Ministry
Heart Congress on August 7 to 10, 2014 in China, of Health, Labor, and Welfare, the number of regis-
4.5 million individuals had a HF diagnosis in 2013.8 tered medical institutions with a CR program has
Coronary heart disease was the most common HF been steadily increasing: from 186 institutions in
cause, followed by other conditions, such as 2005 to 608 in 2011.14 However, according to
hypertension and rheumatic heart disease. Be- JACR, the number of the medical institutions
tween the ages of 35 and 74 years, the prevalence providing outpatient CR was only 325 in 2013.
of HF in China was 0.9%, 0.7% in men, 1.0% in CR in Japan has been traditionally performed in
women.8 The age of HF onset has become the inpatient setting, and opportunities to partici-
younger in recent years: 66.4  14.1 years be- pate in outpatient CR after hospital discharge
tween 2000 and 2003, 64.9  14.4 years between remain low.
2004 and 2006, and 64.2  14.8 years between Obviously, the limited number of outpatient CR
2007 and 2010 (P<.01).9 In Japan, 1.0 million indi- programs is a major obstacle with respect to avail-
viduals were estimated to have HF in 2005, and ability for qualified patients in Japan.14 A recent
this number is expected to increase to 1.3 million analysis found outpatient CR participation rates
by 2035.10 According to a study carried out by were estimated to be between 3.8% and 7.6% in
the Turkish Society of Cardiology, the incidence Japan.15 Saito and colleagues16 emphasized the
of adult patients with heart disease in Turkey is importance of individualized exercise prescription,
63 per 1000.11 determined by exercise testing, for exercise-
As in Western countries, cardiac rehabilitation based CR. Exercise testing is used to determine
(CR) practice patterns include a healthy diet, the anaerobic threshold (AT) and evaluate exercise
smoking cessation, limited alcohol intake, weight tolerance. Therefore, exercise-based CR dep-
control, stress and sleep management, and exer- ending on individual exercise prescription could
cise training. In addition to these universal compo- decrease adverse cardiovascular events and opti-
nents of CR, Asian countries also commonly mize outcomes.
include other types of physical activity, including In general, CR programs are performed in 3
Taiji (or Tai Chi), Qigong, and Yoga. stages (Table 1): acute (phase I), subacute (phase
II),17,18 and chronic (phase III).19,20 In Japan, most
CARDIAC REHABILITATION IN JAPAN CR programs are phase I, with a lower number of
phase II and III programs.17,18 Some studies
Japan began learning from the West since the suggest that self-monitoring of patient physical
Meiji restoration and gradually transformed into a activity during phase I CR might effectively in-
capitalist country. In conjunction with Japan’s crease the physical activity level in preparation
rapid economic rise, it became the first Asian for entering a phase II CR program.21 Patients
country embarking on the road of industrialization, with coronary artery disease in the chronic phase
and its health care system and health levels now still have problems with physical function and
are comparable to Western countries. coronary risk factors, especially in the elderly pop-
The inception of rehabilitation for patients ulation.17,18,22–24 Phase III CR was sparsely avail-
suffering a myocardial infarction dates back to able until 2006 because of no coverage by health
the 1950s in Japan.12 Since the 1970s, Japan insurance.
began to formalize the concept of CR. The CR Randomized phase III CR trials in Japan
Research Council was established in 1977 and improved several aspects of physical fitness, cor-
the Japanese government implemented the onary risk, and QOL.19,20 These studies used
Heart Failure Rehabilitation Practice in Asian 97

Table 1
Phases of cardiac rehabilitation in Japan

Phase I Phase II Phase III


Period Acute stage Early subacute stage Late subacute stage Chronic stage
Location ICU/CCU General ward Residential or regional Residential or regional
rehabilitation facilities rehabilitation facilities
Objective Regain functional Return to society Return to society, Maintain good habits
mobility functions develop good habits
Abbreviations: CCU, coronary care unit; ICU, intensive care unit.
Adapted from Refs.21–26

weekly supervised exercise sessions at the clinic sports, such as Taiji and Qigong (for more details,
consisting of approximately 15 minutes of warm- see later discussion of CR in China).30,31 In Korea,
up exercise, including stretching, followed by 20 CR is majorly driven by symptom-limited CPET as
to 60 minutes of continuous upright aerobic an objective quantitative criterion for the exercise
exercise (various combinations of walking, bicy- training protocol.
cling, jogging, and other activities), and light iso-
tonic exercise, such as situps and squatting, CARDIAC REHABILITATION IN CHINA
using the patient’s own body weight, followed by The Organizations, Associations, Committees,
approximately 15 minutes of cool-down stretching Guidelines, and Problems of Cardiac
and calisthenics. The intensity of supervised aero- Rehabilitation in China
bic exercise sessions was at the AT level. In addi-
tion, the intervention group participating in phase Before the 1970s in China, most cardiologists and
III CR also performed resistance exercise training clinicians thought that exercise was contraindi-
twice weekly, education on a healthy diet at the cated in patients diagnosed with CVD.12,32–37
onset of the program and every 2 months there- Since the early 1980s, some cardiologists began
after, and weekly counseling at every visit for to investigate the safety and efficacy of CR, initially
6 months.19,20 Some CR programs in Japan also only in 3 Chinese hospitals.38,39 Subsequently, the
include some forms of traditional Chinese exercise number of hospitals with CR programs started to
patterns, such as Taiji and Qigong, but they are increase in the mid-1980s and early 1990s.33–37
less widespread than those in China. Currently, the hospitals with CR programs are
dispersed among 20 provinces (municipal-
CARDIAC REHABILITATION IN SINGAPORE, ities).12,32–37 However, the practice patterns of
HONG KONG, TAIWAN, AND KOREA CR in hospital and other medical care units are still
very simple and poorly standardized.
CR practice using exercise training in Singapore, In 1978, the Chinese Medical Association (CMA)
Hong Kong, Taiwan, and Korea is also similar to established 2 branches: the Chinese Society of
the Western model. In Singapore, several system- Cardiology (CSC) and the Chinese Association of
atic reviews over the past 3 decades have con- Physical Medicine and Rehabilitation. Then, in
sistently demonstrated cardio-protective effects 2007, the CMA established its Sports Medicine
of exercise-based CR programs.25–28 Exercise- Branch to promote CR practice in China. In 1991,
based CR, compared with usual care, reduces the Chinese Association of Rehabilitation Medicine
all-cause mortality by 20% (95% confidence inter- established its branch of Cardiovascular Com-
val, CI: 7%, 32%) and cardiac mortality by 26% mittee (CCCARM) to promote CR practice parti-
(95% CI: 4%, 39%).27 Hong Kong, because it cularly for CVD.35–37 Since December of 2012,
was a Chinese colony governed by United Dr Hu, a cardiologist, as the leader of CCCARM,
Kingdom for 100 years, emulates Western CR pro- has encouraged more cardiologists to promote
grams, which have focused on a didactic provision and use CR.30
of information for patients but less emphasis on In comparing 4 different CMA-CSC’s guidelines
psychosocial components.29 In Taiwan, CR is related with HF from 2007 to 2014,40–43 only the
commonly based on cardiopulmonary exercise last one announced that regular aerobic exercise
testing (CPET). In all 3 above areas, in which the improves cardiac function and symptoms in this
Chinese population is dominant, CR practice chronic disease population (class I, A-level).43
patterns for HF also include Chinese traditional Moreover, this document stated CR is beneficial
98 Sun

for stable HF patients (class IIa, B-level). It also activities, 30 minutes per day, more than 5 days
endorsed a multidisciplinary management sch- per week. Results showed that this training
eme, which includes cardiologists, psychologists, program improved QOL and cardiac function as
nutritionists, physical and exercise therapists, well as decreased morbidity and mortality.55,67,68
primary care physicians (urban and rural medical Other 6-month walking studies47,54,56,69 initiated
communities), nurses, patients, and their family training at 80% to 90% of baseline 6MWD and
members as part of a singular team to improve then gradually increased the distance to 3000 to
CR outcomes and to reduce the risk of rehospital- 5000 steps (z2–3 km), a cumulative time of 40
ization (class I, A-level).43,44 Unfortunately, there to 60 minutes, 4 to 6 days per week. Six months
are still currently very few cardiologists who later, the walking group demonstrated a significant
commonly add CR in their daily clinical practice reduction in rehospitalization and resting heart rate
for HF. as well as a significantly higher 6MWD and LVEF
Last, currently in China, 3 additional major chal- compared with controls. Another study with similar
lenges limit CR practice and require attention: (1) methods found that after CR, plasma angiotensin II
the lack of professionals qualified to oversee a and endothelin-1 decreased significantly.
CR program; (2) those professionals currently
delivering CR, a lower levels of financial compen-
Traditional Chinese Exercise Pattern for
sation; and (3) limited payment support from health
Rehabilitation
insurance.38,45
As briefly mentioned above, rehabilitation in China
has a long history, and Qigong, Taiji, and other
Cardiac Rehabilitation Practice Pattern in
similar approaches are important components of
China
rehabilitation.27,70 Qigong is a mental and physical
There were many studies in China that showed that exercise that focuses on breathing control, phys-
activities such as walking, biking, running, and ical movements, and meditation as the means to
swimming effectively improve cardiac function maintain physical fitness, prevent and cure dis-
and QOL in HF patients.46–57 Beginning in 1992, eases, and live healthy. Taiji is a form of martial
Liu and colleagues58–61 reported 2 to 4 weeks of arts, combining purposeful movements with medi-
walking 100 to 400 meters, twice a day, for AMI tation. It combines various boxing movements in
patients with HF was safe and beneficial. Other conjunction with the change in the Yin (meaning
controlled studies62–65 used a walking intervention of negative) and Yang (meaning of positive) in
in HF cohorts. The rehabilitation group exercised Yijing Chinese medicine meridian. It is a physically
10 to 30 minutes, 4 to 5 times per week, for and mentally involved form of low to medium
20 weeks, and exercise intensity was titrated by intensity aerobic exercise and is feasible and
metabolic equivalents (METs). The rehabilitation safe for HF patients.31,70 Currently prevalent in
exercise group significantly increased 6-minute the elderly population, Taiji combined with exer-
walk distance (6MWD) and left ventricular ejection cise training may synergistically further increase
fraction (LVEF), significantly decreased b-type the benefits of training, particularly in terms of im-
natriuretic peptide (BNP), left ventricular end- proving the QOL and mood.71 Although Taiji and
diastolic dimension, and significantly improved Qigong are widely used in the Chinese population,
QOL scores.62–65 Tian66 used symptom-limited there are a limited number of investigations on its
peak exercise testing to set training intensity value when integrated into a CR program in China.
(40%–80% of peak oxygen consumption [V_ O2]), It may be because these approaches are com-
for 10 to 20 minutes per session, 3 to 7 times per monly accepted as providing a health benefit
week, for 3 months. After 3 months, the patients without any question. A multicenter, single-blind
significantly increased cardiac output, LVEF, randomized controlled study72 compared
stroke volume, cardiac index, and stroke index 12 weeks of Taiji to a control group. Even though
compared with the control group. A series of similar the Taiji exercise group had no significant
studies55,67,68 used progressively increasing improvement in 6MWD and peak VO _ 2, significant
walking time for HF patients: the first week started improvements in self-effectiveness (cardiac mo-
at 5 to –10 minutes per day and then progressed tion self-efficacy instruments), QOL, and mood
to 3 ten-minute sessions per day (30 minutes total), state scores were reported in the training group.
greater than 5 days per week, at a heart rate of 50% Zhuo and colleagues73 studied changes in CPET
to 70% of maximum, for the first 2 months. During parameters in the patients practicing Taiji to
the third to sixth months of training, more exercise indicate the physiologic impact of this exercise
was added, including cycling, jogging, playing approach. All subjects had more than a 5-
volleyball, playing badminton, and other sport year history of Taiji skillful practice history.
Heart Failure Rehabilitation Practice in Asian 99

Cardiopulmonary exercise testing parameters, Cardiopulmonary Exercise Testing and New


such as V_ O2, related metabolic parameters, heart Theoretic System of “Holistic Integrative
rate, and blood pressure, were measured during Physiology and Medicine” for Cardiac
a practice of Taiji (which lasted 17–25 minutes, Rehabilitation in China
an average of 22 minutes). The average energy
At present, the evaluation of HF severity and prog-
consumption of the Taiji was 4.1 METs or
nosis includes one or more of the following:
14.5 mL/kg/min, and the average heart rate was
(1) New York Heart Association functional classifi-
134 bpm. These values suggested that the prac-
cation; (2) some form of objective functional
tice of Taiji can be classified as a mild to moderate
assessment; (3) LVEF; and (4) BNP. These evalua-
form of exercise intensity, with an intensity level of
tions are, however, not sufficient in objectively
no more than 50% of peak V_ O2. Zhou and col-
reflecting the patient’s clinical presentation in a
leagues74 studied the positive improved effects
comprehensive manner.79 Ideally, an assessment
of Qigong on blood lipids and heart functions, indi-
should accurately reflect disease severity, a
cated that Chinese traditional methods play a
heterogeneous phenomenon in patients with HF,
unique important role in modern rehabilitation.
as well as the magnitude of physiologic/clinical
Square dance has become popular in China,
improvement following the implementation or titra-
particularly in the elderly female population; this
tion of an intervention. Cardiopulmonary exercise
is a simple, free, and easy-to-learn style of dancing
testing satisfies all of the aforementioned desirable
pattern that allows for sustained physical acti-
assessment attributes. Cardiopulmonary exercise
vity. Similar to Taiji, square dance is a low-to-
testing merges traditional exercise testing moni-
moderate intensity aerobic exercise that many
toring procedures (ie, electrocardiography, he-
elderly Chinese citizens perform to maintain
modynamics, and subjective symptoms) with
fitness in public spaces. Although there is lack of
ventilator expired gas analysis. This additional
scientific analysis on square-dance patterns for
technique can accurately quantify minute ventila-
patients with HF, it is reasonable to posit this
tion (V_ E), V_ O2, and carbon dioxide production
approach would improve functional capacity in
(V_ CO2) at rest and throughout exercise.79–84
this chronic disease population. However, future
Cardiopulmonary exercise testing is currently
scientific analysis in this area is encouraged to
the gold standard for the noninvasive integrated
support this hypothesis.
evaluation of all systems involved in the aerobic
Researchers who are not from China have
exercise response.80 It can be an objective and
also assessed traditional Chinese methods for
quantitative evaluation of cardiopulmonary func-
CR.31,71,72,75–77 A challenge to integrating these
tion and exercise tolerance, better predict holistic
findings into the local health care model is that
health status, optimal parameter of selection, and
Chinese citizens tend to put greater belief and trust
management for heart transplant, and predict
from individuals sharing their culture background;
outcome.81 However, many clinicians and experts,
this results in less scientific investigation in China
commonly based on the systemic physiology,
and a lack of common standard use of Chinese
have poor understanding of the integrative physi-
traditional methods for CR in HF patients.
ology and pathophysiology of CPET and clinical
A meta-analysis on 14 studies conducted by
importance and safety of CPET.78,81,83,84 At least
Taylor and colleagues27 reported that Taiji was
in China, the standard CPET-guided CR investiga-
effective in improving aerobic capacity. In a recent
tion is still very rare. Since 2012, came back China
meta-analysis study, Pan and colleagues31 pooled
to work for establishing national center of CVD, the
data from 4 randomized controlled trials (n 5 242).
author has been prompted to use CPET for
The results suggested that Taiji significantly
personalized CR, and has been hold both training
improved QOL but was not associated with a sig-
courses of “theoretical basic and clinical practice
nificant reduction in BNP, systolic/diastolic blood
of CPET” and “standardizing practice for CPET”
pressure, improved 6MWD, and peak V_ O2.
twice a year.
Taiji may promote cardiovascular health and can
Rooted in the holistic concepts of Chinese tradi-
be considered an alternative exercise program for
tional culture background and with the deep
patients with HF. However, the study design and
understanding of the principles of oxygenation in
training protocols from different Taiji studies vary
the human body described by modern medical
significantly, and hence, the results are difficult
science, Sun78,83 established the fundamental
to compare. In future research, large samples,
structure of a new theoretic system of “Holistic
multicenter randomized controlled trials, and us-
Integrative Physiology and Medicine,” which has
ing standardized training protocols should be
been developed over the last 30 years, was first
considered in accordance with the guidelines of
announced at the 2011 American Physiology
exercise prescription for patients with HF.78
100 Sun

Society conference,85 and was fully described in 8 weeks of Yoga classes. Yoga classes lasted
2013. 60 minutes and were conducted twice weekly for
Cardiopulmonary exercise testing is a contin- a total of 16 classes over an 8-week period. Key
uous dynamic record of all integrated respiratory, findings were (1) a modified Yoga program was
circulatory, metabolic, and neurohumoral activities safe in stable HF patients; and (2) the modified
during a physical stimulus. Thus, CPET is an ideal Yoga program improved physical function mea-
tool to assess holistic integrative physiology and sures, such as strength, balance, and endurance
medicine as well as a unique guide and method as well as perception of symptom stability and
for delivering a highly individualized CR program. QOL.102 In another study,103 researchers exam-
In using this new theory to guide the interpretation ined the effect of 4 weeks of Yoga-type breathing
of standardized clinical CPET, a holistic human training in patients with HF and found that
physiologic functional assessment, diagnosis and dyspnea, exercise tolerance, and oxygenation
differential diagnosis of disease, disease severity were improved.
evaluation, evaluation of therapeutic efficacy,
patients management and prognosis prediction CARDIAC REHABILITATION IN BROADER
can more accurately be achieved.84,86–97 From a REGIONS OF SOUTH ASIA
CR standpoint, an important perspective gained
from CPET is identifying AT to pinpoint the optimal Including India, south Asia is the most densely
intensity for aerobic training.88–91 Moreover, populated geographic region in the world. People
disease/dysfunction of the heart, lungs, circulatory of South-Asian origin (ie, from India, Pakistan, Sri
systems, or periphery manifest specific and Lanka, and Bangladesh) have an increased risk
relatively unique abnormalities that are amplified of developing HF and experiencing cardiovascular
during exercise and CPET can elegantly charac- death.103–106 Although CR is effective, South
terize these patterns.84,86–97 Asians are among the least likely people to partic-
ipate in these programs. There are several factors
CARDIAC REHABILITATION IN INDIA associated with this lack of participation.107
Indeed, the emerging themes identified in the liter-
In India, there are mainly 2 rehabilitation practice ature point toward several salient factors associ-
patterns: one is the traditional Western mode ated with South-Asian patients’ experiences of
and the other is Yoga. Regardless of the approach, CR that are commensurate with low uptake and
CR in a structured manner is in a nascent stage in adherence. In particular, structural barriers relating
India, with the first phase II telemetry monitored to referral, timing, location, and availability of
programs being available only in the initial years transport were common, in addition to cultural
of the twenty-first century. However, most hos- and exercise-related barriers and language and
pitals across the country that care for HF patients translation difficulties.108–113 There is emerging
do offer phase I CR.98 Currently, there is limited evidence to suggest that South Asian women, in
evidence assessing CR outcomes in India. Al- particular, appear to experience unique and
though data from Western countries have shown compounding social and cultural barriers to
that exercise training is valuable in patients with attending and participating in conventional CR
HF, the Indian context is very different. There are programs.111,112,114
only 2 published studies on exercise training in However, a few researchers have disaggregated
HF available from India: one is a case series and their data by ethnic origin to describe what might
the other one is a clinical trial, both with promising best meet the needs of South Asian patients.
findings.99,100 There is consensus that CR is effec- Further research is needed to thoughtfully address
tive and necessary in CVD populations,101 and issues of uptake of and compliance with CR by
continued efforts are therefore needed to conti- South Asian patients and to support the deve-
nue CR research in India and facilitate clinical lopment of culturally sensitive and safe CR
applications. programs.107
Yoga is a typical exercise pattern and commonly
popular in India and other areas in Southeast Asia, SUMMARY
South Asia, and China. Yoga practice is safe, and
participants experience improved physical func- Given differences in economy, culture, race, stan-
tion and symptom stability. Yoga exercise and dards of medical practice, and development sta-
breathing are a nonpharmacologic intervention tus and others, it is no surprise that the practice
that may ameliorate autonomic nervous system of CR in patients with HF and local supporting
tone and skeletal muscle function in HF. In one evidence varies widely. There are many rehabilita-
study,102 patients with HF were asked to complete tion practice patterns in Asia, including not only
Heart Failure Rehabilitation Practice in Asian 101

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