BSc BIOMEDICAL SCIENCES year 2 ; PHYSIOLOGY

Assignment 1; DUE 20 February 2024

TOPICS; THE cell, Body Fluid Compartment and transport across cell membranes

INSTRUCTIONS

- It should be handwritten
- It should be written in groups of 5
- Indicate the names and i.d numbers of group members on the assignment
- Avoid writing unnecessary information
- Late submission will be punished heavily

THE CELL

1. State any 4 functions of the cell membrane? And describe clearly the composition
of the cell membrane?

2. The terms below relate to Cells. Define the following terms briefly;
a. Apoptosis b. Necrosis c. Atrophy c. Hypertrophy d.
Hyperplasia e. Dysplasia f. Metaplasia.

BODY FLUID COMPARTMENTS AND SOLUTES.

3. A patient's serum sodium concentration is measured at 70 mmol/L. If the normal

range is 135-145 mmol/L, determine whether the patient's sodium level is within
the normal range and discuss the potential clinical implications.

4. The diagram below shows Edema of the lower extremity

Define edema? Explain how it may develop and cause abnormal changes in body
fluid volumes?

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BSc BIOMEDICAL SCIENCES year 2 ; PHYSIOLOGY

5. Calculate the total body water in a person weighing 70 kg, assuming that 65% of
their body weight is water. Calculate
a. Total body water b. ECF c. ICF d. IF

6. ECF volume and osmolality regulation is controlled by three hormones.

Aldosterone, ADH, atrial natriuretic hormone. Describe clearly the mechanism of
action of ADH?

MOVEMENTS OF SUBSTANCES BETWEEN COMPARTMENTS.

7. Enumerate and define the various subcategories of mechanism involved in

transport of substance across the cell membrane
8. Describe the mechanism of operation of the Na+/K+ pump? What will be the effect
of drugs such as digoxin on this pump?
9. Show the transport mechanisms involved in the absorption of glucose in the
intestines?
10. Show mechanism involved in the exocytosis of insulin from the pancreatic beta
cells?
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PHYSIOLOGY DEPARTMENT