Sibelium 10 Mg

Sibelium 10 Mg This drug classified as a calcium channel blocker. It is used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an aid in the therapy of epilepsy. Buy Sibelium 10 mg 150 tablets (Brand Name)$55.00 Pharmacological action Sibelium 10 Mg: Selective BCCI, a derivative difenilpiperazina; has cerebrovascular selectivity improves blood flow to the brain, has a protivomigrenoznoe, vasodilatation, anticonvulsant, antihistamine, sedative and antihypoxia action. Relaxes the smooth muscles of blood vessels, prevents them from cramping, slight increases peripheral blood vessels, improves cerebral blood flow, especially in ischemic areas. No effect on the conductivity and contractility of the heart muscle does not affect heart rate. Virtually has no hypotensive effect. Prevents the development of migraine headaches, normalize the vestibular function, reduces symptoms of cerebral and peripheral ischemia. Reduces the incidence and severity of headache of vascular origin. Maximum therapeutic effect develops within a few weeks after starting therapy. Indications Sibelium 10 Mg: Migraine (prophylaxis of attacks); neurological disorders with subarachnoid hemorrhage, dizziness, cerebral blood flow (atherosclerosis of cerebral vessels, hypoxia) and the vestibular labyrinth disorders, disorders of peripheral circulation; epilepsy (in the combined therapy). Contra Sibelium 10 Mg: Hypersensitivity, period laktatsii.C caution. Depression (including history), extrapyramidal disorders (including a history of Parkinsons syndrome), abnormal liver function, advanced age. Side effects Sibelium 10 Mg: From the CAS: excessive lowering of blood pressure, angina, until the development of myocardial infarction (at the beginning of treatment or when the dose increases, particularly in patients with severe obstructive coronary artery disease), arrhythmias, bradycardia or tachycardia, tides of blood to the skin of the face and the feeling fever, exacerbation of CHF. The nervous system: dizziness, headache, extrapyramidal (Parkinson) of violation (ataxia, maskoobraznoe face, shuffling gait, muscle rigidity, tremor of hands and fingers, difficulty in swallowing), depression, drowsiness, fatigue, asthenia. From the digestive system: dry mouth, nausea, constipation or diarrhea, gingival hyperplasia (bleeding, pain, swelling), increased appetite, stomachodynia. From the musculoskeletal: arthralgia, swelling of the joints. From the hemopoietic system: an asymptomatic agranulocytosis, asymptomatic thrombocytopenia. Allergic reactions: skin rash. Other: transient loss of vision on the background of Cmax, pulmonary edema (shortness of breath, cough, breathing stridoroznoe), peripheral edema, weight gain, rarely galaktoreyaPeredozirovka. Symptoms: tachycardia, decreased blood pressure. Treatment: with a decrease in blood pressure infusions of plasma-solutions, dopamine, dobutamine.

Dosage and administration: Inside. For the prevention of migraines and dizziness 10 mg 1 every day for the night. Epilepsy 15-20 1 mg once a day. Children weighing less than 40 kg designate 1 / 2 dose recommended for adults. Special instructions: In the initial period of treatment should refrain from activities potentially hazardous activities that require attention and speed of mental and motor responses. Caution must be exercised with concomitant administration of flecainide. May increase the concentration of prolactin in plasma. Despite the lack of BCCI syndrome cancel before the termination of treatment is recommended a gradual reduction in dose. Interaction: In an application with BCCI inhaled anesthetics may pronounced decrease in blood pressure. Preparations Ca2 + can reduce the effectiveness of BCCI. Cimetidine increases the concentration of BCCI in the plasma ranitidine and famotsidin no significant effect on the metabolism of BCCI. Procainamide, quinidine and other drugs causing prolongation QT, reinforce the negative inotropic effect and may increase the risk of significant prolongation QT. Strengthens the neurotoxicity of drugs Li + (nausea, vomiting, diarrhea, ataxia, tremor, tinnitus). Rifampicin can reduce the bioavailability due to induction of hepatic metabolism.