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Legato Treatment Results Skin Barrier Breakthrough System

Maria Claudia Almeida Issa, MD, PhD

Associate Professor, Department of Clinical Medicine Fluminense Federal University Rio de Janeiro, Brazil

Issa, MD, PhD Associate Professor, Department of Clinical Medicine Fluminense Federal University Rio de Janeiro, Brazil
Dr. Maria Claudia Almeida Issa MD, PhD D r. Maria Claudia Almeida Issa is among

Dr. Maria Claudia Almeida Issa

MD, PhD

Dr. Maria Claudia Almeida Issa is among the leading dermatologists in Brazil and South America. She has had 9 articles published in dermatology trade journals, and has presented her findings at 15 international conferences.

Dr. Issa holds a PhD in Dermatology from the Federal University of Rio de Janeiro (2008) and a MsC in Dermatology from the Fluminense Federal University (1997). Dr. Issa has been registered as a dermatologist with the Brazilian Society of Dermatology since 1995.

Dr. Issa is currently an Associate Professor within the Department of Clinical Medicine – Dermatology, at the Fluminense Federal University. Her research focuses on Photodynamic Therapy, non-Melanoma Skin Cancer, Lasers, Photoaging and Dermal Remodeling. In addition, Dr. Issa operates her own clinic called Dermavance Dermatologia, located in Niteroi, Rio de Janeiro.

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Introduction:

Introduction: The Legato Skin Barrier Breakthrough System for Trans-Epidermal Delivery. T he Legato was developed to

The Legato Skin Barrier Breakthrough System for Trans-Epidermal

Delivery.

The Legato was developed to overcome the challenge of introducing cosmeceuticals beneath the skin without interference from the stratum corneum (outer layer of skin barrier). The Legato is a dual stage system that uses RF and ultrasound technologies to introduce cosmeceuticals beneath the skin’s surface. The protocol first calls for fractional skin ablation and creating microchannels in the skin. The Legato then harnesses the power of acoustic ultrasonic waves, pushing cosmeceuticals into these microchannels directly to the area that will most benefit from the active ingredients. The Legato is designed for the treatment of scars and stretch marks - two indications for which there is no effective solution which is not highly invasive. Other indications that may benefit from the delivery of cosmeceuticals directly beneath the skin include skin whitening and skin rejuvenation.

iPixel RF

include skin whitening and skin rejuvenation. iPixel R F T he first step of the Legato

The first step of the Legato solution is to create microchannels in the skin. The Legato uses the iPixel TM RF , a radio wave generator that causes precise and controllable thermal damage and fractional ablation. As the iPixel RF makes contact with the skin, small plasma sparks are released that pierce the epidermis and cause fractional skin ablation - forming the microchannels. Each microchannel is 80-120 microns in diameter and has a depth of 100-150 microns, depending on the RF-power settings.

Cosmeceuticals

microns, depending on the RF-power settings. Cosmeceuticals The advantage of Trans-Epidermal Delivery compared to

The advantage of Trans-Epidermal Delivery compared to topical, oral, and hypodermic injections - is the ability to deliver the appropriate dose of cosmeceuticals directly to the location that will most benefit. When cosmeceuticals are introduced directly to biological tissue, they are more deeply absorbed and provide a stronger therapeutic effect. Until now, the main problem with effective delivery of skin care products/cosmeceuticals, was the fact that the stratum corneum is an effective barrier to outside elements. Cosmeceuticals are applied to the skin following the creation of the microchannels due to the fractional skin ablation. The cosmeceuticals are forced through the microchannels by the Impact Ultrasound unit.

Impact

the microchannels by the Impact Ultrasound unit. Impact Impact is the name of the ultrasound unit

Impact is the name of the ultrasound unit that acts as a vibrator, releasing acoustic waves that push the cosmeceuticals into the skin via the microchannels. The acoustic vibrations of the ultrasound leads to radiation pressure that gives the cosmeceuticals greater mobility and reactivity. This increases the amount of cosmeceuticals that enter the body, thereby increasing the affectivity of the cosmeceuticals.

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Legato Treatment Settings

Legato Treatment Settings Face (iPixel R F ) Treated area Power [W] Neck 40 Chin 40

Face (iPixel RF )

Treated area

Power [W]

Neck

40

Chin

40

Cheeks

45

Periorbital

40

Forehead

45

Body (iPixel RF )

Treated area

Power [W]

Hand

40

Abdominals

45

Waist

45

Hip

40

Buttocks

45

Treatment

Waist 45 Hip 40 Buttocks 45 Treatment T he Legato Skin Barrier Breakthrough System was used

The Legato Skin Barrier Breakthrough System was used on 30 patients with pathologic scars, including 13 patients with atrophic scars and 17 patients with hypertrophic changes. In addition, 27 patients had striatal atrophy of the skin. All of the patients received a minimum of 4, and maximum of 8 sessions. By the 5th session, a partial reduction in the scar tissue was indicated.

(Of note, the skin color was closer to the natural color.) Other noted changes in the appearance of the skin following the use of the Legato include a decrease in skin tension by the scar and the reduction in height or depth of the scar. In addition, using basal blood flow assessment with a Doppler flowmeter, the edema of the adjacent tissue decreased due to improvements of the blood circulation.

Conclusions

due to improvements of the blood circulation. Conclusions I t is the author’s belief that the

It is the author’s belief that the combined use of cosmeceuticals with

a delivery system like the Legato is highly effective. In particular, the

realized synergies between cosmeceuticals and a delivery system include improved clinical and functional effects. The author is not aware of any alternative solution that is comparable to the Legato. The Legato may be used for mature scars, post acne scars, stretch marks, skin whitening, skin rejuvenation, and immediately following the removal of sutures.

post acne scars, stretch marks, skin whitening, skin rejuvenation, and immediately following the removal of sutures.

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Legato Treatment Results Skin Barrier Breakthrough System

Scars

Scars

Scars Before 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in

Before

Scars Before 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in

1 week after 2 Tx

Scars Before 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45 W, 3 passes Cosmeceutical: Triancinolona Impact: 60 Hz, 80%, 1 min

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Scars

Scars Before After 2 Tx Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist, Moscow, Russia

Before

Scars Before After 2 Tx Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist, Moscow, Russia

After 2 Tx

Scars Before After 2 Tx Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist, Moscow, Russia

Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist, Moscow, Russia

RF: 45 w Cosmeceutical: Contractubex Impact: 40 Hz, 50%, 1 min

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Scars

Scars Before 10 days after 4 Tx Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist,

Before

Scars Before 10 days after 4 Tx Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist,

10 days after 4 Tx

Scars Before 10 days after 4 Tx Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist,

Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist, Moscow, Russia

RF: 50 w 2-3 passes Cosmeceutical: Contractubex Impact: 40 Hz, 50%, 1 min

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Scars

Scars Before 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in

Before

Scars Before 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in

1 week after 2 Tx

Scars Before 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 40W, 2 passes Cosmeceutical: Hyaluronic Acid + Vit C Impact: 60 Hz, 80%, 1 min

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Scars

Scars Before After 4 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio

Before

Scars Before After 4 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio

After 4 Tx.

Scars Before After 4 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 40W, 2 passes Cosmeceutical: Hyaluronic Acid + Vit C Impact: 60 Hz, 80%, 1 min

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Scars

Scars Before After 1 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio

Before

Scars Before After 1 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio

After 1 Tx.

Scars Before After 1 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45W, 3 passes Cosmeceutical: Triancinolona Acetonide Impact: 60 Hz, 80%, 2 min

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Scars

Scars Before After 1 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio

Before

Scars Before After 1 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio

After 1 Tx.

Scars Before After 1 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45W, 3 passes Cosmeceutical: Triancinolona Acetonide Impact: 60 Hz, 80%, 2 min

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Legato Treatment Results Skin Barrier Breakthrough System

Acne Scars

Acne Scars

Acne Scars Before After 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Before

Acne Scars Before After 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

After 2 Tx

Acne Scars Before After 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45W, 3 passes Cosmeceutical: Tretinoin 0.05% Impact: 60 Hz, 80%, 2 min

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Acne Scars

Acne Scars Before After 3 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Before

Acne Scars Before After 3 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

After 3 Tx.

Acne Scars Before After 3 Tx. Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45W, 3 passes Cosmeceutical: Tretinoin 0.05% Impact: 60 Hz, 80%, 2 min

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Acne Scars

Acne Scars Before After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60

Before

Acne Scars Before After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60

After 3 Tx

Acne Scars Before After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60

Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai

RF: 60 W, stationary and iPixel RF (In Motion), 6 passes Cosmeceutical: Dalacine (Clindamycin)

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Acne Scars

Acne Scars Before After 6 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 40-50

Before

Acne Scars Before After 6 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 40-50

After 6 Tx

Acne Scars Before After 6 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 40-50

Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai

RF: 40-50 W (Treatments 1-5), 100 W (Treatment 6), iPixel RF (IN Motion), 7 passes Cosmeceutical: Locoid (hydrocortisone butyrate) Impact: 40 Hz, 50%, 2 min

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Acne Scars

Acne Scars Before 1 week after 1 Tx Courtesy of: Choi Jun, MD, PhD, MayLin Clinic,

Before

Acne Scars Before 1 week after 1 Tx Courtesy of: Choi Jun, MD, PhD, MayLin Clinic,

1 week after 1 Tx

Acne Scars Before 1 week after 1 Tx Courtesy of: Choi Jun, MD, PhD, MayLin Clinic,

Courtesy of: Choi Jun, MD, PhD, MayLin Clinic, Seoul, Korea

RF: 55-65 W, 4-5 passes Cosmeceutical: PRP Impact: 60 Hz, 50%, 2 min

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Acne Scars

Acne Scars Before After 3 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 45-50W, 2-3 passe

Before

Acne Scars Before After 3 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 45-50W, 2-3 passe

After 3 Tx

Acne Scars Before After 3 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 45-50W, 2-3 passe

Courtesy of: Dr. Michael Shohat, Dermatologist

RF: 45-50W, 2-3 passe Cosmeceutical: Meso anti Wrinkle,1% HA, MicroAcne kit Impact: 60 Hz, 80%, min

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Legato Treatment Results Skin Barrier Breakthrough System

Legato Treatment Results Skin Barrier Breakthrough System

Strech Marks

Stretch Marks

Stretch Marks Before After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Before

Stretch Marks Before After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

After 4 Tx

Stretch Marks Before After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45 W, 3 passes Cosmeceutical: Hyaluronic Acid + Vitamin C Impact: 60 Hz, 80%, 4 min

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Stretch Marks

Stretch Marks Before After Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de

Before

Stretch Marks Before After Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de

After

Stretch Marks Before After Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45 W,3 passes Cosmeceutical: Hyaluronic Acid + Vitamin C Impact: 60 Hz, 80%, 4 min

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Before Stretch Marks After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in

Before

Stretch Marks

Before Stretch Marks After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

After 4 Tx

Before Stretch Marks After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45 W – 2 crosses (4passes) in motion tip Cosmeceutical: tretinoin 0,05% Impact: 60 Hz 80%

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Stretch Marks

Stretch Marks Before After 1 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 55W, 2 passes

Before

Stretch Marks Before After 1 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 55W, 2 passes

After 1 Tx

Stretch Marks Before After 1 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 55W, 2 passes

Courtesy of: Dr. Michael Shohat, Dermatologist

RF: 55W, 2 passes Cosmeceutical: Meso Striae kit Impact: 60 Hz, 50%, 5 min

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Stretch Marks

Stretch Marks Before After 3 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 55W, 3 passes

Before

Stretch Marks Before After 3 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 55W, 3 passes

After 3 Tx

Stretch Marks Before After 3 Tx Courtesy of: Dr. Michael Shohat, Dermatologist RF: 55W, 3 passes

Courtesy of: Dr. Michael Shohat, Dermatologist

RF: 55W, 3 passes Cosmeceutical: Meso Striae kit Impact: 80 Hz, 50%, 3 min

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Stretch Marks

Stretch Marks Before 14 days after 2 Tx Courtesy of: Dr. Igor Pinson, MD & PhD,

Before

Stretch Marks Before 14 days after 2 Tx Courtesy of: Dr. Igor Pinson, MD & PhD,

14 days after 2 Tx

Stretch Marks Before 14 days after 2 Tx Courtesy of: Dr. Igor Pinson, MD & PhD,

Courtesy of: Dr. Igor Pinson, MD & PhD, Dermatologist Moscow, Russia

RF: 45 W, 3 passes Cosmeceutical: Hyaluronic Acid + Vitamin C

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Legato Treatment Results Skin Barrier Breakthrough System

Skin Rejuvenation

Skin Rejuvenation

Skin Rejuvenation Before 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD

Before

Skin Rejuvenation Before 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD

1 week after 2 Tx

Skin Rejuvenation Before 1 week after 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 40 W, 3 passes Cosmeceutical: Retinoic Acid 0,05% Impact: 60 Hz, 80%, 60 sec periocular +120 sec-malar and mandibular

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Skin Rejuvenation

Skin Rejuvenation Before After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Before

Skin Rejuvenation Before After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

After 4 Tx

Skin Rejuvenation Before After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 40 W, 3 passes Cosmeceutical: Anti-Wrinkle+Retinoic Acid (RA) Impact: 60 Hz, 80%, 1 min

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Skin Rejuvenation

Skin Rejuvenation Before After 3 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Before

Skin Rejuvenation Before After 3 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

After 3 Tx

Skin Rejuvenation Before After 3 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45 w Cosmeceutical: Tretinoin 0,05%+ HÁ 5% + VIT C 5% Impact: 60 HZ 80%

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Skin Rejuvenation

Skin Rejuvenation Before After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Before

Skin Rejuvenation Before After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

After 4 Tx

Skin Rejuvenation Before After 4 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 45 w Cosmeceutical: Glicolic acid 10% + Hydro- quinone 4% Impact: 60 Hz 80%

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Skin Rejuvenation

Skin Rejuvenation Before After 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Before

Skin Rejuvenation Before After 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

After 2 Tx

Skin Rejuvenation Before After 2 Tx Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology,

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 40W, 2 passes Cosmeceutical: Vit C + Hyaluronic Acid Impact: 60 Hz, 80%, 1 min

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Skin Rejuvenation

Skin Rejuvenation Before After 4 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60

Before

Skin Rejuvenation Before After 4 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60

After 4 Tx

Skin Rejuvenation Before After 4 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60

Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai

RF: 60 W, 2 stationary passes Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min

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Skin Rejuvenation

Skin Rejuvenation Before After 2 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 55

Before

Skin Rejuvenation Before After 2 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 55

After 2 Tx

Skin Rejuvenation Before After 2 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 55

Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai

RF: 55 W, 3 passes Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min

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Skin Rejuvenation

Skin Rejuvenation Before After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 50W,

Before

Skin Rejuvenation Before After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 50W,

After 3 Tx

Skin Rejuvenation Before After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 50W,

Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai

RF: 50W, 4 passes stationary Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min

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Skin Rejuvenation

Skin Rejuvenation Before 1 week after 1 Tx Courtesy of: Maria Claudia Issa, MD & PhD

Before

Skin Rejuvenation Before 1 week after 1 Tx Courtesy of: Maria Claudia Issa, MD & PhD

1 week after 1 Tx

Skin Rejuvenation Before 1 week after 1 Tx Courtesy of: Maria Claudia Issa, MD & PhD

Courtesy of: Maria Claudia Issa, MD & PhD in Dermatology, Rio de Janeiro, Brazil

RF: 40W, 3 passes Cosmeceutical: Meso DMAE Impact: 60 Hz, 80%, 2 min

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Before Skin Rejuvenation After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF:

Before

Skin Rejuvenation

Before Skin Rejuvenation After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60W,

After 3 Tx

Before Skin Rejuvenation After 3 Tx Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai RF: 60W,

Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai

RF: 60W, 3 stationary passes and 2 IN Motion passes Cosmeceutical: Vitamin C,Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min

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