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Niranjan Murthy H L
NERVOUS SYSTEM
1) Central nervous system- Brain & Spinal cord 2) Peripheral nervous system
STRUCTURE OF NEURON
Nerve cell with all its processes is neuron
Parts:I. Axoni) generally long ii) arises from axon hillock iii) axis cylinder has axoplasm, neurofibrils & mitochondria iv) axons end in terminal buttons v) carry impulses away from cell body II. Dendrite:i) multiple & short ii) contain nissl granules iii) carry impulses towards soma
III. Cell body:- Neurocyton or Soma i) Nucleus- pale, large, spherical, central ii) Neuroplasm- has neurofibrils, nissl granules, mitochondria, golgi apparatus, neurosecretory material
CLASSIFICATION OF NEURONS
I. (a) Golgi bottle type I (b) Golgi bottle type II II. Anatomic classificationa) Unipolar b) Pseudounipolar c) Bipolar d) Multipolar e) Apolar
III. Physio-anatomic classificationa) afferent i) somatic ii) visceral b) efferent i) somatic ii) visceral IV. Depending on myelination a) myelinated b) unmyelinated
proprioception, somatic 12-20 motor A touch, pressure 5-12 A motor to muscle spindle 3-6 A pain, temperature, 2-5 touch B preganglionic autonomic <3 C i) Dorsal root- pain, touch, 0.4-1.2 ii) postganglionic 0.3-1.3
VI. Numerical classification Number origin fiber type Ia Muscle spindle, A annulospiral ending Ib Golgi tendon organ A II Muscle spindle, flower-spray A ending, touch, pressure III Pain, temperature, touch A IV Pain dorsal root C fibers
MYELINATION
Nerve cells in grey matter are naked. As they enter white matter they acquire myelin sheath. As the nerve leaves CNS it acquires neurolemma (sheath of schwann) Myelin sheatha protein-lipid complex Envelops the axon except at its ending & at nodes of ranvier
MyelinogenesisInside CNS myelin is produced by oligodendroglia & outside CNS by schwann cells Schwann cell wraps around axon up to 100times. This is compacted by apposition of protein zero. Nodes of ranvier are periodic 1m constrictions which are 1mm apart where there is no myelination
PROPERTIES OF NERVE
I. EXCITABILITY- its the ability of a
cell to produce action potential in response to a stimulus. action potential- its a self-propagating change in potential across a cell membrane.
LOCAL RESPONSE
Stimulus- its a change in environment which brings about a change in potential across a membrane in an excitable tissue
Types of stimulii) Electrical ii) Chemical iii) Thermal iv) Mechanical v) Electromagnetic it can also be classified into subliminal, minimal (threshold), sub-maximal and maximal, depending on the strength of stimulus.
STRENGTH-DURATION CURVE
STRENGTH
2 X RHEOBASE
RHEOBASE
CHRONAXIE
UTILISATION TIME
TIME
RHEOBASE- minimum current required to produce action potential. UTILIZATION TIME- time taken for response when rheobase current is applied. CHRONAXIE- time taken for response when twice rheobase current is applied. It is a measure of excitability of tissues.
II. CONDUCTIVITY
Action potential is self-propagative Conduction may orthodromic or antedromic In axon, conduction is towards terminal buttons physiologically. In myelinated nerves, conduction is saltatory type.
STIMULUS
+ + + + + + + + + + + + + + + + + + + + + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + + + + + + + + + + + + + + + + + + + +
+ + + + + + + + - - - - - + + + + + + + + + + - - - - - - - - - - + + + + + - - - - - - - - - - - - - - - - - - - - - - + + + + + - - - - - - - - - - + + + + + + + + - - - - - + + + + + + + + +
Efflux of K+ ions
repolarization
* The frequency of action potential increases with the increasing intensity of stimulus.
IV.REFRACTORY PERIOD
1) Absolute refractory periodit is the period during an action potential, during which a second stimulus cant produce a second response.
2) Relative refractory periodit is the period during an action potential, during which a stimulus of higher intensity can produce a second response
V.ACCOMODATION
When a stimulus is applied very slowly, no matter however strong it might be, it fails to produce an action potential. Cause: a slowly applied stimulus causes slower opening of Na+ channels with concomitant opening of K+ channels. The influx Na+ of is balanced by efflux of K+ .