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  • Obat-Obat Anti Kolinergik Untuk Mengatasi Efek Samping Kolinesterase Inhibitor

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    Maps
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    This document compares the effects of atropine, scopolamine, and glycopyrrolate. It finds that atropine causes the most tachycardia and sedation, while scopolamine causes the most bronchodilation and antisialagogue effect. It then lists the muscarinic side effects of cholinesterase inhibitors on different organ systems. Finally, it provides recommendations on usual doses of cholinesterase inhibitors and matching anticholinergic drugs to treat any muscarinic side effects.

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    Original Title

    Antikolinergik-zamrud

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    This document compares the effects of atropine, scopolamine, and glycopyrrolate. It finds that atropine causes the most tachycardia and sedation, while scopolamine causes the most bronchodilation and antisialagogue effect. It then lists the muscarinic side effects of cholinesterase inhibitors on different organ systems. Finally, it provides recommendations on usual doses of cholinesterase inhibitors and matching anticholinergic drugs to treat any muscarinic side effects.

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    8 views31 pages

    Obat-Obat Anti Kolinergik Untuk Mengatasi Efek Samping Kolinesterase Inhibitor

    Uploaded by

    Maps
    This document compares the effects of atropine, scopolamine, and glycopyrrolate. It finds that atropine causes the most tachycardia and sedation, while scopolamine causes the most bronchodilation and antisialagogue effect. It then lists the muscarinic side effects of cholinesterase inhibitors on different organ systems. Finally, it provides recommendations on usual doses of cholinesterase inhibitors and matching anticholinergic drugs to treat any muscarinic side effects.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
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    of 31

    OBAT-OBAT ANTIKOLINERGIK

    Atropine

    Scopolamine

    Glycopyrrolate

    Tachycardia

    +++

    ++

    Bronchodilatation ++

    ++

    Sedation

    +++

    Antisialagogue
    effect

    ++

    +++

    +++

    Efek samping muskarinik dari Kolinesterase Inhibitor.


    OrganSystem

    MuscarinicSideEffects

    Cardiovascular

    Decreased heart rate, bradyarrhythmias

    Pulmonary

    Bronchospasm, bronchial secretions

    Cerebral

    Diffuse excitation1

    Gastrointestinal

    Intestinal spasm, increased salivation

    Genitourinary

    Increased bladder tone

    Ophthalmological

    Pupillary constriction

    Cholinesterase
    Inhibitor

    Usual Dose of Recommended


    Cholinesterase
    Anticholinergic
    Inhibitor

    UsualDoseof
    Anticholinergic
    permgof
    Cholinesterase
    Inhibitor

    Neostigmine

    0.040.08 mg/kg

    Glycopyrrolate

    0.2 mg

    Pyridostigmine

    0.10.4 mg/kg

    Glycopyrrolate

    0.05 mg

    Edrophonium

    0.51 mg/kg

    Atropine

    0.014 mg

    Physostigmine1

    0.010.03 mg/kg

    Usually not
    necessary

    NA

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