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Cholangitis
Cholangitis
Management of
Choledocholithiasis
Ruby Wang MS 3
Surg 300A
8/20/07
Content
Case
Cholangitis
Clinical manifestations
Diagnosis
Treatment
Diagnosis and management of choledocholithiasis
Pre-operative
Intra-operative
Post-operative
Case
HPI:
86 yo lady p/w 3-4 episodes of RUQ/mid-epigastric abdominal
pain over the last year, lasting generally several hours,
accompanied by occasional emesis, anorexia, and sensation
of shaking chills.
ROS: negative otherwise
PE:
VS: T 36.2, P98 , RR 18, BP 124/64
Abdominal exam significant for RUQ TTP
Labs
AST 553, ALT 418. Alk Phos 466. Bilirubin 2.7
WBC 30.3
Imaging
Abdominal US: multiple gallstones, no pericholecystic fluid, no
extrahepatic/intrahepatic/CBD dilatation
Introduction
Causes
Choledocholithiasis
Obstructive tumors
Pancreatic cancer
Cholangiocarcinoma
Ampullary cancer
Porta hepatis
Others
Strictures/stenosis
ERCP
Sclerosing cholangitis
AIDS
Ascaris lumbricoides
Epidemiology
Nationality
Sex
U.S: uncommon, and occurs in association with biliary obstruction and causes of
bactibilia (s/p ERCP)
Internationally:
Oriental cholangiohepatitis endemic in SE Asia- recurrent pyogenic
cholangitis with intrahepatic/extrahepatic stones in 70-80%
Gallstones highest in N European descent, Hispanic populations, Native
Americans
Intestinal parasites common in Asia
Gallstones more common in
women
M: F ratio equal in
cholangitis
Age
Pathogenesis
High pressure diminishes host antibacterial defenseIgA production, bile flow- causing immune dysfunction,
increasing small bowel bacterial colonization.
E Coli (25-50%)
Klebsiella (15-20%),
Enterobacter (5-10%)
Adam.about.com
Gpnotebook.co.uk
Pathology.med.edu
Clinical Manifestations
RUQ pain (65%)
Fever (90%)
May be absent in elderly patients
Jaundice (60%)
Hypotension (30%)
Altered mental status (10%)
Additional History
Pruitus, acholic stools
PMH for gallstones, CBD stones,
Recent ERCP, cholangiogram
Additional Physical
Tachycardia
Mild hepatomegaly
Charcots
Triad:
Found in
50-70%
of
patients
Reynolds
Pentad:
Metabolic panel
Amylase/Lipase
Involvement of lower CBD may cause 3-4x elevated amylase
Blood cultures
20-30% of blood cultures are positive
Advantage:
Sensitive for intrahepatic/extrahepatic/CBD dilatation
CBD diameter > 6 mm on US associated with high prevalence of choledocholithaisis
Of cholangitis patients, dilated CBD found in 64%,
Rapid at bedside
Can image aorta, pancreas, liver
Identify complications: perforation, empyema, abscess
Disadvantage
Not useful for choledocholithiasis:
Of cholangitis patients, CBD stones observed in 13%
10-20% falsely negative - normal U/S does not r/o cholangitis
acute obstruction when there is no time to dilate
Small stones in bile duct in 10-20% of cases
CT
Advantages
CT cholangiograhy enhances CBD stones and increases detection of biliary pathology
Sensitivity for CBD stones is 95%
Can image other pathologies: ampullary tumors, pericholecystic fluid, liver abscess
Can visualize other pathologies- cholangitis: diverticuliits, pyelonephritis, mesenteric
ischemia, ruptured appendix
Disadvantages
Sensitivity to contrast
Poor imaging of gallstones
Med.virgina.edu
Advantage
Detects choledocholithiasis, neoplasms, strictures, biliary dilations
Sensitivity of 81-100%, specificity of 92-100% of
choledocholithiasis
Minimally invasive- avoid invasive procedure in 50% of patients
Disadvantage:
cannot sample bile, test cytology, remove stone
Contraindications: pacemaker, implants, prosthetic valves
Indications
If cholangitis not severe, and risk of ERCP high, MRCP useful
If Charcots triad present, therapeutic ERCP with drainage should
not be delayed.
Endoscopic retrograde cholangiopancreatography (ERCP)
Advantage
Therapeutic option when CBD stone identified
Stone retrieval and sphincterotomy
Disadvantage
Complications: pancreatitis, cholangitis, perforation of duodenum
or bile duct, bleeding
Diagnostic ERCP complication rate 1.38% , mortality rate 0.21%
Medical Treatment
Antibiotics
Empiric broad-spectrum Abx after blood cultures drawn
Ampicillin (2g/4h IV) plus gentamicin (4-6mg/kg IV daily)
Carbapenems: gram negative, enterococcus, anaerobes
Levofloxacin (250-500mgIV qD) for impaired renal fxn.
Surgical treatment
Surgery
Emergency surgery replaced by nonoperative biliary drainage
Once acute cholangitis controlled, surgical
exploration of CBD for difficult stone removal
Elective surgery: low M & M compared with
emergency survey
If emergent surgery, choledochotomy carries
lower M&M compared with cholecystectomy
with CBD exploration
Our case
Condition:
ERCP attempted
Intraoperative cholangiogram
Choledocholithiasis
Pre-op
Intra-op
Post-op
Diagnosis: Clinical history and exam, LFTs, Abdominal U/S, CT, MRCP
High risk (>50%) of choledocholithiasis:
clinical jaundice, cholangitis,
CBD dilation or choledocholithiasis on ultrasound
Tbili > 3 mg/dL correlates to 50-70% of CBD stone
Moderate risk (10-50%):
h/o pancreatitis, jaundice correlates to CBD stone in 15%
elevated preop bili and AP,
multiple small gallstones on U/S
Low risk (<5%):
large gallstones on U/S
no h/o jaundice or pancreatitis,
normal LFTs
Treatment:
ERCP
Surgery
Treatment
Open CBD exploration
Intraoperative ERCP
Results: Initial stone clearance higher with open surgery (88% vs 65%, p< 0.05)
Conclusion: routine preoperative ES not indicated
Stain et al. Ann Surg 1991; 213: 627-34
Design: 237 patients with CBD stone and intact gallbladders, 66% managed with ES and rest with open
choledochotomy
Results: No significant difference in morbidity and mortality rates
Lower incidence of retained stones after open choledochotomy
Conclusion: open surgery superior to ES in those with intact gallbladders
Miller et al. Ann Surg 1988; 207: 135-41
Design: 8 trials randomized 760 patients comparing ERCP with open surgical clearance
Results: Open surgery more successful in CBD stone clearance, associated with lower mortality
Conclusion: open bile duct surgery superior to ES
Cochrane database of systematic reviews 2007
Study design:
Randomized, prospsective trial of 82 patients with choledocholithiasis and severe toxic
cholangitis managed endoscopically or with open choledochotomy
Results: In group managed initially with endoscopic drainage, need for ventilatory support (29% vs 63%)
and mortality (33% vs 66%) significantly less
Conclusion: toxic cholangitis should managed with endoscopic sphincterotomy
Lai et al. J Engl J Med 1992; 326: 1582-6
Laparoscopic CBD
Exploration
Techniques
IOC define biliary anatomy: size and length of cystic duct, size of bile duct stones
Choledochotomy
Transcystic approach
Results
ERCP
Treatment of retained stones undetected or left
behind
In summary
our case
Open procedure
Cholecystectomy
CBD exploration