Disruption in the normal vaginal ecosystem Alteration of vaginal pH A decrease in lactobacilli Growth of other bacteria Cervical mucus Endometrial fluid Fluid from Skenes and Bartholins glands Exfoliated squamous cells Normal pH: 3.5 4.5 during reproductive years; 6 8 after menopause Bacterial Vaginosis: 15 - 50% of cases; all ages; anaerobic bacteria and Gardnerella vaginalis Trichomonas: 15 - 20% of cases; 20-45 years; protozoan Trichomonas vaginalis Candida: 33% of cases; premenopausal women: 90% caused by Candida albicans Yeast: oral fluconazole 150mg single dose, or intravaginal clotrimazole, miconazole, or terconazole. Trichomonas: oral metronidazole 2 grams in a single dose or 500mg bid for 7 days. Bacterial Vaginosis: oral metronidazole 500mg bid for 7 days, or intravaginal clindamycin cream or metronidazole gel.