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Chapter ten

Biosynthesis of nucleotide
Topic: Biosynthesis and regulation pyrimidine nucleotide
Outline:
• Composition of Pyrimidine nucleotide
• Synthesis of Pyrimidine nucleotide (CTP & UMP)
• Regulation Pyrimidine nucleotide synthesis.
Teaching and learning methods: Lectures, visual aid, interactive forms, assignment
and group discussion.
At the end of this lecture student should be able to answer following questions.
• Mention the Nitrogen base for Pyrimidine nucleotide.
• Illustrate the synthesis of Pyrimidine nucleotide (CTP & UMP).
• Explain the regulation Pyrimidine nucleotide synthesis.
Reference books:
1.Lelinger Principles of Biochemistry- Nelson DL Cox MM; 6th edition, chapter 22;
page: 867-875
2.Bacterial Metabolism, 2nd Edition- Gottschalk G; Chapter two; page: 59-62
3.Microbial Physiology- Moat AG & Foster IF 4th Edition, chapter 16; page: 550-555

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