Professional Documents
Culture Documents
Animal Biotechnology
Animals in Research
Animals in Research
B1 B2
B3
B4
Animals in Research
Animation of
Drug
Development
Process
Animals in Research
z Animal Models
• Mice
• Rats
• Zebrafish (3 month generation time,
200 progeny, complete embryogenesis
in 120 hrs)
• Dogs (lungs and cardiovascular
system)
• Cats
• Pigs (PPL Therapeutics- delete a gene
which causes hyperacute rejection of
pig-to-human organ transplantation)
• Primates (HIV and AIDs research,
geriatric research)
Animals in Research
z Cloning
• Creating Dolly
• Limits to Cloning: The donor cell must
come from a living organism
• An organism is also shaped by its
environment
• The success rate for cloning is very low
• Clones may be old before their time
• The future of cloning: preservation of
endangered animals, studying the effect
of drugs etc on duplicates, improve
agricultural production
Transgenic Animals
z Retrovirus-mediated transgenesis
z Pronuclear microinjection
z Embronyic stem cell method
z Sperm-mediated transfer
Transgenic Animals
z Production of Monoclonal
antibodies (Mabs)
• Used to treat cancer, heart
disease, and transplant
rejection
• HUMANIZED monoclonal
antibodies were developed
to prevent the human anti-
mouse antibody (HAMA)
response