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  • Bone Morphogenetic Proteins: Proteolytic Cleavage

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    Nina Bend
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    Bone morphogenetic proteins (BMPs) are signaling proteins that contain a signal sequence, pro-domain, and mature domain. After proteolytic cleavage, the mature domain dimerizes and binds to type I and type II serine/threonine kinase receptors, activating Smad or MAPK signaling pathways that regulate target genes involved in bone formation.

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    BMP proteins

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    Bone morphogenetic proteins (BMPs) are signaling proteins that contain a signal sequence, pro-domain, and mature domain. After proteolytic cleavage, the mature domain dimerizes and binds to type I and type II serine/threonine kinase receptors, activating Smad or MAPK signaling pathways that regulate target genes involved in bone formation.

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    © All Rights Reserved
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    5 views2 pages

    Bone Morphogenetic Proteins: Proteolytic Cleavage

    Uploaded by

    Nina Bend
    Bone morphogenetic proteins (BMPs) are signaling proteins that contain a signal sequence, pro-domain, and mature domain. After proteolytic cleavage, the mature domain dimerizes and binds to type I and type II serine/threonine kinase receptors, activating Smad or MAPK signaling pathways that regulate target genes involved in bone formation.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    Bone Morphogenetic Proteins

    Signal
    N Sequence
    Pro-domain Mature Domain C
    C C C C C C C

    Proteolytic cleavage

    C C C C C C C

    C C C C C C C Folding & dimerization

    C
    Active BMP dimer
    C

    Eric Niederhoffer
    SIU-SOM
    BMP Signaling Pathways

    C C
    C
    C C
    C GS box

    Type II Type I
    receptor receptor
    MAPK pathway (s)
    Smad pathway

    Target gene

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