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• Patients are at risk of infection from
their own resident micro
organisms(endogenous infection)
3
• Some microorganisms essential for
maintaining health (no harmful effect
on the body)→ non-pathogens).
• Colonies of non-pathogens present in
the body known as normal body flora
• Flora not the same in all body areas,
e.g. normal flora in the intestines is
different from the normal flora of the
skin.
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• Non-pathogens misplaced to another part of
the body can become pathogens; e.g.
intestinal flora entering the urinary bladder
can cause a urinary tract infection.
• Infections that are acquired in the hospital
are called nosocomial infections or hospital
acquired infection.
Fundamentals of nursing II 5
Local infection
• Only a specific portion of the body is
infected
• Pain
• Redness
• Heat at the site
• Swelling
• Pus
• Foul smelling drainage Fundamentals of nursing II 6
Systemic infection
Affects the entire body
• Fever
• Aches
• Chills
• Nausea
• Vomiting
• Weakness
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Chain of Infection (Infection cycle)
Infection:
Is a disease state that results from the presence
pathogens in the body.
Communicable disease is infection transmitted
directly from one person to another.
If the pathogens multiply and cause clinical signs
and symptoms, the infection is symptomatic.
If clinical signs and symptoms are not present, the
illness is termed asymptomatic.
Fundamentals of nursing II 8
Chain of Infection (Infection cycle)
The six components in the infection cycle are:-
Fundamentals of nursing II 9
1.Infection /Causative Agent
Bacteria
• Viruses
• Fungi
• Protozoa
Fundamentals of nursing II 10
2.Reservoir (sources)
• Human with active cases of disease or
those that carry disease without having
symptoms
• Animals/insects
• Fomites
• Environment
Fundamentals of nursing II 11
3- Portal of Exit(Causative Agent)
• Tears (slight risk)
• Saliva/respiratory tract secretions
• Urine
• Feces
• Wound drainage
• Reproductive tract
secretions
• Blood
Fundamentals of nursing II 12
4- Mode of Transmission
The four main routes of transmission are:
A-Contact transmission :
Direct → contact body surface to body surface
(kissing and sexual intercourse).
Indirect → susceptible host is exposed to a
contaminated object (dressing, needle or surgical
instrument).
B-Droplet transmission that occurs when mucous
membranes of the nose, mouth, or conjunctiva are
exposed to secretions of an infected person who is
coughing, sneezing or talking.
Fundamentals of nursing II 13
C-Vehicle transmission: vehicle (contaminated
items) as food that can carry Salmonella, water,
drugs and blood that can carry hepatitis and AIDs.
D-Airborne transmission → fine particles are
suspended in the air for a long time or when dust
particles contains pathogens.
These organisms can be inhaled by or deposited on
the skin of a susceptible host.
Fundamentals of nursing II 14
5- Portal of Entry
Cuts/break in skin
Openings in the
mucous membranes
Respiratory system
Gastrointestinal
system
Urinary system
Reproductive system
Mother to fetus
Fundamentals of nursing II 15
6- Susceptible Host
• Human being: that
can be affected by an
agent.
Susceptibility:
• Poor diet
• Fatigue
• Inadequate rest
• Stress
• poor health
Fundamentals of nursing II 16
Factors increased the liability to infection
lack immunity.
Age (immunity declines as age increases)
Illness and Injury
Stress (decreases immune response)
Immunization/Vaccination Status
Lifestyle (sharing needles, multiple sex partners,
smoking, alcohol and drug abuse)
Fundamentals of nursing II 17
Occupation (chemical agents, needle sticks)
Skin breaks which is the first line of defense
(surgical, pressure ulcer, IV)
Nutritional Status (overweight, underweight)
Heredity
Medications (steroids, non-steroidal anti-
inflammatory agents NSAIDs (ibuprofen,
aspirin), chemotherapy, antibiotics lead to
vaginal yeast infections
Nursing and Medical Procedures (urinary
catheters, IV)
Fundamentals of nursing II 18
Three main factors determine whether the
pathogen successfully causes infection:
1. Susceptibility of the host
2. Amount of the pathogen.
3. The presence of all elements of the
infection chain
Fundamentals of nursing II 19
Body Defenses
1.Non-Specific Immune Responses
a. Skin and its normal flora
b. Mucous membranes
c. Coughing, sneezing, tearing reflexes.
d. Elimination and acid environment
e. Flora in the large intestine prevent growth of
pathogens and peristalsis removes them with
feces.
f. Natural urine acidity prevents growth of
microorganisms
g. Vaginal Flora is acidic
Fundamentals of nursing II 20
2-Specific Immune Response
Fundamentals of nursing II 21
Course of infection(stages of infection)
1-Incubation Period:
There is an interval between entrance of
pathogen into the body and appearance of
first symptoms.
2-Prodromal Stage Of Illness:
A person is most infectious during it .
Early signs and symptoms of disease are
present but are vague and non specific
Fundamentals of nursing II 22
3-Full Stage Of Illness
Client manifests signs and symptoms
specific to type of infection.
For example:
Common cold (sore throat, sinus
congestion, rhinitis)
Mumps (earache, high fever, parotid and
salivary gland swelling).
Fundamentals of nursing II 23
4- Convalescence
Fundamentals of nursing II 24
Nosocomial infection
(Hospital acquired infection)
Fundamentals of nursing II 25
Types :
1. Iatrogenic infection
Resulting from a diagnostic or therapeutic procedure (urinary
catheter insertion).
2. An exogenous infection
The causative organism is acquired from other people, such
as Tuberculosis.
3. Endogenous infections
When sufficient numbers of microorganisms normally found
in one body cavity transferred to another body
site(transmission of enterococci, normally found in fecal
material, from the hands to the skin is a cause of wound
infections).
Major sites for nosocomial infection include the urinary
tract, surgical wounds, the respiratory tract, and the
bloodstream.
Fundamentals of nursing II 26
Risk factors for nosocomial infection
1. Environment
2. Therapeutic regimen
Drugs such as steroids.
Equipment
Inadequate dressing techniques for
wounds
3. Client resistance
4. Multiple health care personnel caring for
a client
5. Extended length of hospitalization
Fundamentals of nursing II 27
Clinical signs and symptoms of infection
1-Systemic (general) manifestations: Fever, fatigue,
malaise, lymph node enlargement, loss of appetite,
nausea, and vomiting may be found.
2- Localized manifestations: Redness, swelling, pain
or tenderness, and restricted movement of a body
part occur. There may be drainage from open
lesions or wounds.
3- Laboratory data:
WBC count, erythrocyte sedimentation rate(ESR),
urine, blood, sputum or other drainage culture add.
Fundamentals of nursing II 28
Breaking Chain of Infection
A-Infection Control is the First Line of
Defense by:-
1-Hand hygiene is the single most practice in
preventing the spread of infection
2-Wear gloves, masks, gowns and goggles
3-Client Hygiene
4-Dressing Changes using aseptic technique
5-Clean linens
6-Clean Equipment and maintain aseptic
technique.
Fundamentals of nursing II 29
Breaking Chain of Infection
B-Educate on covering mouth and nose when
coughing and sneezing; throwing tissues into
garbage bag
C-Nutrition (protein needed to maintain and
repair tissues, production of antibodies, and acid-
base balance
D-Exercise
E-Immunizations (measles الحصبه, mumps النكاف,
rubella الحمي المانية, tetanus every 10 years and flu
every year.
Fundamentals of nursing II 30
Asepsis
The
two types of the nurse practices are:
Medical asepsis
Surgical asepsis.
Fundamentals of nursing II 31
Medical Asepsis
Medical or Clean Asepsis reduces the
number of organisms & prevents their
spread.
During daily routine care, to break the
infection chain.
Fundamentals of nursing II 32
1.Hand Hygiene
Hand washing
Hand RUB
Fundamentals of nursing II 33
When to Wash Hands
Before and after contact with patient or patient’s
belongings
Before and after eating
After using the bathroom
After handling any contaminated fluid or object
After touching body fluids
Before and after wearing gloves
Between tasks and procedures on the same patient
to prevent cross-contamination of different body
sites
Fundamentals of nursing II 34
2.Carry soiled items away from body.
3.Do not place soiled items on floor.
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6.Personal Grooming:
Shampoo hair
Fingernails
Short; ¼ inch
Clean
Smooth
No artificial nails, No overlays. These harbor
bacteria
Do not wear rings with grooves and stones
Keep hair off shoulder
Fundamentals of nursing II 36
7.Personal Protective Equipment (PPE)
Is any equipment or supplies used to protect
clients and healthcare workers.
Clean and sterile gloves
Clean gowns
Masks
Face shields
Protective eye wear
Surgical caps
Shoe covers
Fundamentals of nursing II 37
Surgical Asepsis(Sterile techni- que)
Fundamentals of nursing II 38
The nurse may also use surgical aseptic
techniques at the client's bedside
(inserting intravenous catheters).
During procedures that require
intentional perforation of the client's skin
(surgical incision).
It includes surgical hand washing, sterile
gloves and sterile field. `
Fundamentals of nursing II 39
Categories
Sterilization
Disinfection
Cleaning
Fundamentals of nursing II 40
1. Sterilization: It is a process by which all
forms of microorganisms including spores
are destroyed.
Critical items – need to sterilization
Items that enter sterile tissue or vascular
system.
Surgical instruments - Cardiac catheters-
Urinary catheters -Needles -Implants
Fundamentals of nursing II 41
STERILIZATION
This process can be carried out by 4 methods:-
HEAT IRRADIATION
- moist heat (Autoclave) - ultra violet light
- dry heat (Hot Air Oven) - gamma rays
CHEMICAL FILTRATION
- in solution - applicable to
pharmaceutical laboratory
where it is used in
combination with ultra
violet light.
Fundamentals of nursing II 42
2. Disinfection: It is eliminates almost all pathogen
organisms on objects, with the exception of
bacterial spores.
This process can be carried out by two methods:
1. Physical - boiling
2. Chemical - disinfectants
Semi critical items-Disinfection
• Respiratory therapy equipment
• Endotracheal tubes
• Gastrointestinal endoscopes
• Reusable mercury thermometers
Fundamentals of nursing II 43
3- Cleaning: Is the removal of all foreign materials such
as soil & organic material from objects.
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(2)Wash hands after glove removal
(3)Protect clothing with apron or gown when
splashing of blood or body fluids is possible
(4)Discard needles or other sharps in puncture-
resistant container
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Isolation system
Fundamentals of nursing II 47
1-Transmission- based precautions:
Fundamentals of nursing II 48
B-Droplet precautions
• The client should be in a private room or
with a person who is infected with the same
microorganism.
• Personnel are to use masks when working
within 3 feet of the client.
• The client should wear a mask when out side
the room.
Fundamentals of nursing II 49
C-Contact precautions
Used with organisms that transmitted by hand or
skin to skin contact(during client care or when
touching the patient environmental surface or care
items).
The client is cared for in a private room.
Personnel use gloves when entering the room and
remove gloves before leaving the room.
Gowns and other protective barriers.
Fundamentals of nursing II 50
2-Protective isolation
Used in high risk situations to prevent
infection for people whose body defenses are
known to be compromised(clients who are
neutropenic (neutrophils less than 500/mm) as
a result of chemotherapy, radiation therapy or
immunosuppressive medications are prime
candidates.
Clients with extensive burns or dermatitis.
Such clients are placed in private rooms.
Visitors are restricted.
No fresh fruits or vegetables are allowed, only
canned and cooked foods. 51
Role of the nurse
Fundamentals of nursing II 53