INTERPHASE STAGE

Interphase is the phase of the cell cycle

in which a typical cell spends most of its
life. During this phase, the cell copies its
DNA in preparation for mitosis.
INTERPHASE STAGE
 G1 Phase
 The cell cycle begins with G1,
or first gap, which is the time
between birth of a new cell and
the beginning of DNA
replication.
 During G1, the cell grows in
size and begins protein
synthesis and organelle –
specialized and organized
structures – duplication.
 G1 Phase
 The cell monitors its
environment to ensure that
external conditions are suitable
for cell division.
 The first internal checkpoint on
cell division also occurs in the G1
phase, verifying that DNA is not
damaged before proceeding to
the DNA duplication step.
 S Phase
After passing through the first
internal checkpoint, the cell
enters the S phase, or
synthesis phase.
 During the S phase, DNA is
duplicated so that each
chromosome contains two
identical copies.
S Phase
 These DNA copies do not
separate into duplicate
chromosomes until after the
interphase stages end and
mitosis or cell nucleus division
begins.
 The S phase ends when the
total amount of DNA has
doubled and the cell enters the
G2 phase.
 G2 Phase

 During the second gap, or G2 phase,

the cell continues to grow in size and
produce proteins necessary for cell
division.
 Microtubules, filamentous internal
structures, necessary for separating
the chromosome copies are made
during this phase.
 The second internal checkpoint
that determines if the cell can
continue through its cycle occurs
in G2.
 While the G1 checkpoint checks
to verify DNA is error free before
replication, the checkpoint in G2
confirms the new DNA is error
free after replication.
 G0 Phase

Cells can also pause interphase

during G1 and enter a resting state
called G0.
 If the conditions outside the cell
do not support division, the cell
pauses in G0 for an indeterminate
amount of time before resuming
the cell cycle and normal growth.
G0 Phase
If conditions change, the cell
can either move from G0
back into the G1 phase, or
become post-mitotic and
leave the cell cycle
completely.
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