Professional Documents
Culture Documents
Renin Angio Sys 1
Renin Angio Sys 1
Afferent
Macula
Densa
JG Apparatus
Efferent
Factors Affecting Renin Release
Increased By Decreased By
•Na+, water
•Arterial BP retention
•BP in Glomerular Renin
•BP
Vessels Release
•Activation of AT1
•Loss of Na+, receptors (short
water loop negative feed
•Sympathetic back)
activity
•Renin- synthesized, stored and released by exocytosis
into renal artery circulation by JG cells
•Both renin and prorenin are stored in the JG cells
•Prorenin is converted to renin by proteolytic enzymes-
proconvertase I or cathepsin B
•Concentration of prorenin is about 10 times higher than
renin in circulating blood
•Renin converts angiotensinogen to angiotensin I which
is then converted to angiotensin II by Angiotensin
Converting Enzyme (ACE)
•Angiotensin II is the active form of the enzyme
Control of Renin Secretion
•Macula densa pathway
•Intrarenal baroreceptor pathway
•-receptor pathway
Macula densa pathway
•Specialized columnar epithelial cells in thick
ascending limb of the nephron
•Lies between the afferent and efferent arterioles
adjacent to the JG apparatus
•Reabsorption of NaCl occurs by macula densa cells
•Changes in NaCl reabsorption modify renin release
from the JG cells
•Increase in NaCl flux causes inhibition of renin
release while decrease causes increased renin release
•ATP, adenosine & PG modulate this pathway
Macula densa- control of renin release
AngII
ATP
Na+ +
Na+-K+-2Cl- Na -ve Feed back
+
symporter 2Cl- K+ AT1 NE release
K+ 1
ADP P2Y
—
(Gq-PLC-IP3 -
Tubular Adenosine Ca2+ PG
COX-2 PG