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EXTRACELLULAR

AND
INTRACELLULAR
COMMUNICATION

By:
Taufiq RN
Biomedical importance

Plasma
membrane
Plasma Membrane
Separate one cell from another
Permit cellular individuality
Selective permeabilities maintenance
differences in composition between the
inside and outside of the cell
The Selective permeabilities provided by
Channels and pump for ions and
substrates
Exocytosis and endocytosis for exchanges
material with the extracellular environment
through gap junction
Plasma Membrane
 Plays key role in cell-cell interaction and
in transmembrane signaling
 Changes in membrane structure can
affects water balance and ion flux end
therefore every process within the cell 
diseases
 The normal cell functions are

depend on integrity of the


membrane
Concentration of Various
Molecules
Maintenance of The Cell Balance between intra
and extra environment is fundamental for
living
Saturated fatty acid/
Unsaturated fatty acid (non polar tail)

Polar head

Non polar
tail
Plasma Membrane

Composed by: Lipid membrane C/O:


 Lipid  Phospholipid
 Protein (phosphogliceride)–
 Carbohydrate glicerol binding
 (Non Covalent fatty acids and
Bond) phosphorilated
 Thermodynamically alcohol
stable
 Metabolically active
 Glycosphyngolipid
 Cholesterol
Transfer of Material and Information across
Membrane

Cross membrane movement of small molecules


Diffusion (passive, facilitated)
active transport
Cross membrane large molecules
Endocytosis
Exocytosis
Signal transduction across membranes
Cell surface Receptors
1. signal transduction
2. signal internalization ( coupled with endocytosis;
LDL)
Movement to intracellular receptors
ssive transport– electrochemical gradien
Endocytosis
Exocytosis
gnaling through steroid receptors
H

HS
HS
P
P

protein
R

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