COMPARATIVE EFFECTIVENESS OF

GENISTEIN AGLYCONE, ALENDRONATE,

RALOXIFENE, AND ESTRADIOL FOR
OSTEOPOROSIS

NURLAILA LAGA
1 3 07 0 6 2 1 3 5
 BACKGROUND

Osteoporosis

Traditional Synthetic
Medicine Drugs

Genistein dari
kedelai Alendronate raloxifene Estradiol
 To determine the effectiveness of
Objective Genistein aglycone in preventing
osteoporosis

Methods

www.Pubme
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d.com

Review Artikel

www.google.
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com
Results:
From the results of a review of the journal, can be
generated that compound genistein aglycone from
soybean (Glycine max L) has the efficacy to prevent
osteoporosis.
Genistein aglycone effective for preventing osteoporosis.

Keywords:
Genistein, osteoporosis postmenopouse, soybean
(Glycine max L)
 RESULTS AND DISCUSSION
Article title,
No Author, Method Sample Result
Year.
”Effects of genistein RCT 96 rats were ovariectomized Genistein at a dose of 10 mg /
1. aglycone in (OVX) were divided into 8 kg showed a large increase in
osteoporotic, groups. 1. Genistein BMD lebig and BMC than other
ovariectomized rats: a aglycone (dose 1 and 10 mg drugs. genistein significantly
comparison with / kg), 2. Alendronate (0.003 improve bone quality in OVX rats
alendronate, raloxifene and 0.03 mg / kg), 3.
and oestradiol” Bitto. A., Raloxifine hydrochloride
et al 2008 (0.05 and 0.5 mg / kg), 4. A-
ethyl estradol (0.003 and
0.03 mg / kg)
“The Bone-Protective RCT OVXdibagi 100 rats in 5 Genistein at a dose of 4.5 mg / kg , 9.0
2. Effect of Genistein in
groups. 20 as a placebo, 2. mg / kg , 18 mg / kg per day ,
the Animal Model of
Bilateral Ovariectomy: respectively effect on ovariectomized
20 given genistein (4.5 mg /
Roles of Phytoestrogens rats . Meanwhile , kelaian PTHR1
and PTH/PTHR1 kg), 20 given genistein (9.0
attenuated by genistein . This strongly
Against Post- mg / kg), 20 given genistein
Menopausal supports the idea that in addition to
Osteoporosis” Qing (18 mg / kg) and 20 given the estrogen , genistein interacts with
Miao., et al., 2012 nilestriol (1.5 mg / kg). PTH/PTHR1 that effect as an anti -
osteoporosis .
3. “Genistein aglycone 28 Sprague-Dawley rats Genistein from soy
reverses induced with methyl
showed greater
glucocorticoid-induced prednisolone 30 mg / kg
osteoporosis and effectiveness in
for 60 days. Genistein
increases bone
aglycone then given 5 mg / preventing osteoporosis
breaking strength in
kg and 0.03 mg
rats: a comparative compared with
study with alendronate / kg
alendronate” Irrera.N., alendronate.
et al., 2009
4 “Effects of Genistein 90 postmenopausal Genistein treatment
and Hormone-
Replacement Therapy osteoporotic patients. 30 can significantly
on Bone Loss in Early patients as placebo, 30 given
Postmenopausal prevent or reduce
Women: A genistein 54 mg / day, 30 is
postmenopausal
Randomized Double- given in combination with
Blind Placebo- osteoporosis.
Controlled Study” estradiol 1 mg norethisterone
Morabito.M., et al., acetate 0.5 mg.
2002
CONCLUSION

Based on a review of existing journals to design

experimental preclinical trials it can be concluded
that the compounds genistein found in soy has a
significant effect, and some of these journals also
mention that genistein is more effective than
medication drugs antiosteoporosis as to prevent
osteoporosis.