INDUSTRIAL TRAINING

PRESENTATION ON
ZYDUS CADILA

Prepared By:

MITESH R. PARMAR
Introduction
Zydus cadila is pharmaceutical company located at dabhasha, in Gujarat. It
produces active pharma ingredients (API) and formulations.
Founder : Ramanbhai Patel (1952)
Other plant in Gujarat are at ankleshwar and vatva.
Capacity : 90 million tones
Turnover : IN 2011 IS 4600 CARORES & IN 2017 IT IS 9600 CARORES.
Aim: To become global research based pharmaceutical company in 2020.
Production :
 There are two steps for production of any medical products :

(1) Active pharmaceutical ingredient (API)

 Which is forms after 4 to 5 intermediates product. Also it is in powder
form.
(2) Formulations
 Formulations is process in which different chemical substances is
combined with API to produced final medicinal product. Also the final
product is tablets , syrups , insecticides etc.
Methodology for production :
Research and development (R&D) Lab
Analytical development laboratory (ADL)
Quality assurance (QA)
Quality control (QC)
CINACALCET HYDROCHLORIDE
Properties :
• Molecular formula : C22H23CLF3N
• Molecular weight : 393.88 g/mole
• State : powder Form
• Melting point : 175 °C
• Storage temp. : - 20 °C

Use: It reduces parathyroid hormones which causes cancer of parathyroid gland.

Cost: 560 Rupees Per 30 mg

Side effects : hypoparathyrodism, vomiting , chest pain

Production method:
Description:
Complex reaction
Two reactor are works simultaneously
In first reactor 1 methyl, 1 amine naphthalene hydrochloric acid , toluene and aq.
NaoH takes and start the reactor agitator.
So, it produced toluene solution of 1 methyl, 1 amine naphthalene and NaCL and
H2O as byproduct.
In second reactor hydrogenation of 1 tri fluro toluene , 2 diene propenoic acid
takes placed by using palladium hydroxide catalyst.
Now add reaction mass of reactor 2 in reactor 1 at 150 °C.
 On further treating with NaBH4, THF ,toluene and HCL, we get crude cinacalcet
hydrochloric acid.
Now add methanol or water to extract impurities.
Description contd.
By use of vacuum distillation we get back toluene.
Now the product solution is carried into centrifuge for filtration and tray
drier for drying.
Than product goes for packing.
One time production is 250-300 kg.

OTHER PHARMACEUTICAL PRODUCTS:

• Topiramate
• Atenolol
• Tamsulotion, etc.
Major Equipment:
 REACTORS:
• GLR (glass lined reactor) – used for acidic product
• SSR (stainless steel reactor) – used for basic product

 DRYERS:
• TD (tray dryer)
• VTD (vacuum tray dryer)
• ANFD (agitated nudge filter dryer)

 FILTERS:
• Sparkler filter
• Centrifuge filter
• Cartridge filter
Another Important Sections:
Solvent Recovery Plant (SRP)
• Solvent recovery is most important aspect in any chemical industry.
• This mixed solvent fed in to reactor where it takes heat from steam
and got vaporized and go to distillation column than in condenser and
got condensed.
• Here reactor works as re-boiler.
• The condensed is collected in reflux tank and it is checked by QA
department if result is not satisfactory then its again introduced in
column. If result is satisfactory than its stored in product tank.
Another Important Sections Contd. :
Effluent Treatment Plant (ETP):
• Its not allowed to leave this high TDS water directly into river because
it pollutes the water.

oThere are two sections : (1) MEE & (2) ETP

• MEE – For high TDS
• ETP – For low TDS
Utilities :
Potable water plant

Nitrogen generation plant

Brine cooling plant

How to detect impurities in product?
Thin layer chromatography (TLC):
• Its basically alumina plate on which thin layer of silica gel is made.
• TLC chamber : filled with mobile phase
• In TLC plate we have to put 3 spots starting material , in process and final
product. Then if put in the chamber. So spots are rising on the plate.
• If spot rising at the top than it has O2 impurity , if rise at middle than CL2
impurity.

High performance liquid chromatography (HPLC):

• Its similar to TLC but TLC is not automatic while HPLC is automatic and
according to generated peak it gives information of which impurities is in
the product.
THANK YOU