ANALISIS SINTESIS I

SINTESIS VITAMIN DAN BEBERAPA

ANTIBIOTIK
Sintesis Vitamin A
Synthesis of Grignard reagent
 RETRO KLORAMFENIKOL
OH OH
H
(R) O O OCH3
H2C +
C C
C
(S)
H
-O + NH O-
C C
 - Cl Cl Cl Cl
C N+
H H
SINTON
C O REAGEN
Cl Cl
H chloramphenicol +
OH OH
H
OH OH H2C (R)
H C
(S)
H2C (R) H
-
C NH O-
(S) -
H N+
NH O-
- O
N+
O C

O
CH3 IGF
 IGF
-
-
OH O
H O
+ -
H 2C
  OH
-C C
 (S)
CH2 H H
NH -
O +
- SINTON REAGEN
N+
O C -
+
CH3
O -
O
H
- 
+
O
H + --C
 
CH NH O-
- -
N+
 - O C
+ NH O
-  -
N+
O C CH3
O
REAGEN
O
SINTON
CH3
-
O
-
H +

CH
+ SINTON
-  -
O C (CH3CO)O 
NH- O-
-
N+
CH3
REAGEN
SINTON O
 O
- - -
- O
H + IGF
 H +

CH
- CH
-
Br O - 
+
NH2 Hcl O-
N -
N+
REAGEN
O REAGEN
O

IGF
-
O
H +

CH
-
H O-
N+
REAGEN
O