Magnesium Citrate

as a substitute for
Atacand
By:
Dela Cruz, Angela Justine
Nicdao, Christine Joy
Samera, Natalie
Ibarra, Hahn Sebastian
Ilasin, Venmar
 INTRODUCTION
•High blood pressure is a common
condition which your blood is high
against the walls of your artery
which can cause serious medical
issues like heart diseases.
 INTRODUCTION
•The study is conducted to prove
that magnesium has the same
benefits and cheaper than
candesartan – a supplement that is
effective and shows a significant
decrease on high blood pressure.
BACKGROUND OF THE STUDY
•Magnesium is the fourth
most abundant mineral in
your body and is responsible
for the function of over 350
enzymes in your body.
BACKGROUND OF THE STUDY
•Dr. Yiqing Song
"With its relative safety and low cost,
magnesium supplements could be
considered as an option for lowering
blood pressure in high-risk persons or
hypertension patients,"
BACKGROUND OF THE STUDY
•Magnesium helps to
regulate hundreds of body
systems, including blood
pressure, blood sugar, and
muscle and nerve function.
BACKGROUND OF THE STUDY
•Magnesium helps to regulate
hundreds of body systems,
including blood pressure,
blood sugar, and muscle and
nerve function.
 OBJECTIVES/PURPOSE
OF THE STUDY
•The researchers hope to develop a
new alternative magnesium
additive which has the same
benefits but much cheaper
medication for high blood
pressure.
 STATEMENT OF THE PROBLEM
• The study aims to develop a magnesium supplement that helps to
lower high blood pressure. The study aims to answer the
following questions:
• Is magnesium effective for lowering high blood pressure?
• Is magnesium an alternative low-cost medicine for lowering high
blood pressure?
• Does magnesium have any notable change if the dosages are
increased?
• Is magnesium suggested to be used long term?
• Is magnesium suitable substitute for other commercial medicine?
 HYPOTHESIS
•The researchers assumed that
the magnesium supplement will
greatly help to lower high blood
pressure amongst hypertensive
people.
 HYPOTHESIS
•The magnesium will be effective for
lowering blood pressure because of its
different properties and known to have 300
biochemical reaction on the body and that a
robust action in reducing oxidative stress
marker during treatment, independent of
BP reduction.
 HYPOTHESIS
•The magnesium will be much
cheaper than commercial
]

products and will have the same

effect as candesartan and other
commercial products.
 HYPOTHESIS
•The magnesium will
show a significant
decrease if the dosages
were increased.
 HYPOTHESIS
•Magnesium is safe for most people
when taken by mouth
appropriately. In some people,
magnesium might cause stomach
upset, nausea, vomiting, diarrhea,
and other side effects.
 SCOPE AND LIMITATION
•The researchers focused on magnesium
supplements in helping to lower high
blood pressure on a human body. The
researchers focus on magnesium citrate
and its potential to be an alternative for
magnesium stearate which is used on
candesartan cilexetil.
 SCOPE AND LIMITATION
•This also includes its different side
effects with different dosages. The
study is limited only to magnesium
and its potential to be a substance
that lower one’s blood pressure.
 SCOPE AND LIMITATION

•It covers magnesium

citrate has a potential to
lower blood pressure
because of its benefits.
SIGNIFICANCE OF THE STUDY

•The researchers aim to help

different kinds of people
whether in first, second or
third-class countries.
SIGNIFICANCE OF THE STUDY

•This study aims to help those

elderly who cannot afford
expensive medication. The
researches want to relieve their
pain as well as their expenses.
SIGNIFICANCE OF THE STUDY
•This study also helps Filipino
patients who are below the poverty
line. Cheaper medication will be a
huge help especially for those who
cannot afford to maintain taking
expensive medication.
 SIGNIFICANCE OF THE STUDY
•The result of the study will be
beneficial to the following:
•Patients
•Doctors
•Researchers
 REVIEW OF RELATED
LITERATURE
•Yiqing Song, M.D., Sc.D., (2016)
•A meta-analysis, funded by the Indiana
University School of Medicine Strategic
Research Initiative, details positive
results that show an association
between a daily intake of magnesium
and a reduction in blood pressure.
 REVIEW OF RELATED
LITERATURE
•Wanpen Vongpatanasin, MD,a,b et al,
(2016)
•A robust action of KMgCit
supplementation in reducing oxidative
stress marker during treatment,
independent of BP reduction.
 REVIEW OF RELATED
LITERATURE
•Wallace, Taylor (2016)
•Magnesium supplements are safe and
relatively low cost they could pose a
practical opportunity to help
hypertensive individuals lower their
blood pressure in patients with
hypertension.
 REVIEW OF RELATED
LITERATURE
•Kass L, et.al. (2012)
•Magnesium supplementation appears to
achieve a small but clinically significant
reduction in BP, an effect worthy of
future prospective large randomised
trials using solid methodology.
RESEARCH METHOD USED
RESEARCH SETTING
•*Add slides if necessary.
POPULATION AND SAMPLE
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RESEARCH PROCEDURE
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INSTRUMENT USED
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DATA GATHERING PROCEDURE

•*Add slides if necessary.

STATITICAL TREATMENT
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•*Show the formula 
PRESENTATION AND
ANALYSIS OF DATA
INITIAL MONDAY FRIDAY MONDAY FRIDAY
1ST WEEK 1ST WEEK 2ND WEEK 2ND WEEK
4 mg 4 mg 8 mg 8 mg

BLOPRESS
CANDESARTAN 138/92 mmHg 127/76 mmHg 128/75 mmHg 126/79 mmHg 124/80 mmHg
CILEXETIL

MAGNESIUM
CITRATE 129/83 mmHg 127/80 mmHmg 127/79 mmHg 126/81 mmHg 123/81 mmHg
SUPPLEMENT

Figure no. 2
PRESENTATION AND
ANALYSIS OF DATA

Blopress Candesartan Cilextil Magnesium Citrate Supplement

Figure no. 3 Effectiveness

PRESENTATION AND
ANALYSIS OF DATA

Blopress Candesartan Cilexetil Magnesium Citrate Supplement

Figure no. 4 Cost

PRESENTATION AND
ANALYSIS OF DATA

Blopress Candesartan Cilexetil Magnesium Citrate Supplement

Figure no. 5 Overall quality

SUMMARY OF FINDINGS
• The researchers aimed to see if magnesium is effective for
lowering blood pressure. Problems like cost, degree of
change, and suggested time of use, arose. The data collected
from the two week long test show a significant difference
between the two supplements. The total cost of all materials
is Php 290.00, for 200 pieces. Which equals out to Php 1.45.
The cost of Blopress or Candesartan Cilexetil. Though
Magnesium Citrate lowers the blood pressure only notably if
dosage is increased.
 CONCLUSIONS
• The overall quality of magnesium citrate as a
substitute for Atacand can be used as a long-term
alternative medication, because data shows that their
is a notable change of blood pressure, and has a
significant price drop compared to Candesartan
Cilexetil (Php 25.00).
 RECOMMENDATIONS
• The researchers recommend a higher amount of
magnesium citrate to significantly lower blood
pressure as compared to 5 tbsp. worth of magnesium.
The researchers also recommend making a more
concentrated solution of the mixture to produce a
stronger supplement. The magnesium citrate is
feasible as a substitute for commercial brands that
lower high blood pressure, if the dosage, usage, and
amount of magnesium per pill/gummy is increased.
 BIBLIOGRAPHY
•*Add slides if necessary.
•*Separate electronic from
thesis/dissertation from
book/magazine.