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Lecture 8
Chapter 4 (end)
Definition -
protein classification
• Grouping of similar proteins based on
their structure, function, or size
– Globular vs filamentous vs helical
– Cataytic vs structural
– Small vs large vs very large
Protein Subunits & Domains
• A single polypeptide may have regions
along its length that fold up separately -
domains
• More than one polypeptide coming
together to form a protein - subunit
04_20_protein domains.jpg
04_21_Serine proteases.jpg
04_22_protein subunit.jpg
04_23_asymmetrical as.jpg
Protein - shapes
• Globular proteins - polypeptide folds tightly
together on itself - most enzymes
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Sample EXAM (Quiz)
Questions
Quiz 1
(Difficulty factor [1-10] = 6)
The smallest unit of life is a(n)
(a) DNA molecule.
(b) cell.
(c) organelle.
(d) virus.
(e) protein.
For each of the following sentences, fill in the blanks with the best word or phrase selected
from the list below. Not all words or phrases will be used; each word or phrase should be
used only once.
Cells can be very diverse: superficially, they come in various sizes, ranging from
bacterial cells such as Lactobacillus, which is a few ___ micrometer(s) __ in length,
to larger cells such as a frog’s egg, which has a diameter of about one ______
millimeter _______. Despite the diversity, cells resemble each other to an astonishing
degree in their chemistry. For example, the same twenty ____ amino acids ______
are used to make proteins. Similarly, the genetic information of all cells is stored in
their ____ DNA __________. Although _______ viruses _____ contain the same
type of molecules as cells, their inability to reproduce themselves by their own efforts
means that they are not considered living matter.
Pro–Val–Thr–Gly–Lys–Cys–Glu
proline-valine-threonine-glycine-lysine-cysteine-glutamic
acid (or glutamate)
B. Write the same sequence using the single letter code
for amino acids. PVTGKCQ
C. According to the conventional way of writing the
sequence of a peptide or a protein, which is the C-terminal
amino acid and which is the N-terminal amino acid in the
above peptide? C-terminal is glutamic acid (or glutamate);
N-terminal is proline.
Which of the following statements about amino acids is TRUE?
(a) Twenty-two amino acids are commonly found in
proteins.
(b) Most of the amino acids used in protein
biosynthesis have charged side chains.
(c) Amino acids are often linked together to form
branched polymers.
(d) D- and L-amino acids are found in proteins.
(e) All amino acids contain an NH2 and a COOH
group.