Professional Documents
Culture Documents
Ancient History
Aztecs
Chinese
Greeks
Ergogenic
Ergon
(work/energy)
Gennan (generate)
20th Century & Supplements
Brown-Sequard in
1889
1950s Dr. Ziegler
Methandrostenolone
IOC
1968 1st list of
banned substances
1976 Montreal
Olympic Games
The Supplement Industry
Timbo, BB, Ross, MP, McCarthy, PV, Lin, CT. (2006) Dietary supplements in a national survey: Prevalence
of use and reports of adverse events. Journal of American Dietetic Association, 106 (12), 1966-74.
Three Questions
Is it effective?
Is it safe?
Is it legal?
Is it Legal?
Governing bodies have banned
substance lists e.g.
S7 - Narcotics
Fentanyl, Morphine
S8 - Cannabinoids
S9 - Glucocorticosteroids
PO, IV, PR, IM - (DOE/TUE)
Topical
P1 - ETOH
P2 - Beta-Blockers
Commonly Used Banned Substances
Erythropoietin & Blood Doping
Natural hormone secreted by the kidney formation
RBCs
r-HuEPO,Darbopoetin (Aranesp)
Blood removed from athlete
1984 - 10 U.S. cyclists
Hemopure (based on bovine Hgb)
2001 Giro d’Italia cycling marathon
Enhances erythropoiesis by stim proerythroblasts
formation
Epo & Doping - Physiology
Endurance Exercise
RBC (red blood cell) mass and plasma volume
increases
Hct & Hgb (hemoglobin) decrease due to expanded
plasma volume
By increasing Hgb & Hct
increases O2 carrying capacity
decreases ratings of perceived exertion
increases VO2 Max a measure of aerobic fitness very
important for endurance exercise
Epo - Proven Effects
EPO for 26 days at 50 IU/kg led to
7% increase in power
9% increase VO2 Max
Increase Hct
After 6 weeks of EPO - 17% increase in cycling time to
exhaustion
IV r-HuEPO works in days
Epo & Doping - Adverse Effects
Proven Benefits
Safe
4-2:1 Ratio
During & After
Not BANNED
Scenario…
19yo patient comes to your office…
Wants to start taking supplement X.
What do you say?…
Supplement Pyramid -
What should I take?
Solid Foundation
Base - T / N / R (training, nutrition, recovery)
2nd Tier
MVI / Ca++/Vit D
Whey Protein/P+C
Fish Oil**
3rd Tier
Other ergogenic aid? E.g. caffeine supplementation
On-line Resources for help
Important Web Sites
http://www.theathlete.org/wada.htm
World Anti-Doping Agency
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