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Genetics and Inheritance
• Heredity: transmission of
traits with variation
• Genes: segments of DNA, we
inherit some from each
parent
• Gametes: Reproductive cells
(plants and animals)
http://arnica.csustan.edu/Biol1010/genetics/alleles.gif
Parent
Bud
Karyotype: humans as an example
Diploid (2n) 46 chromosomes, Haploid (n) 23 chromosomes
Autosomes
◦ 44 Chromosomes
◦ 22 pair = homologs
Sex chromosomes
◦ 2 Chromosomes, only parts are
homologous
◦ 1 pair X and Y
Females XX
Males XY
Somatic Cells (diploid 2n)
◦ 46 Chromosomes, 23 pair
Gametes (haploid n)
◦ 23 Chromosomes, not paired
◦ Reproductive Cells Karyotype:
Stain DNA during mitosis
(condensed)
Used to diagnose disease
Human Life Cycle and Chromosomes
Fertilization:
◦ Haploid Sperm + Haploid Egg
◦ Makes diploid Zygote
Zygote undergoes Mitosis
and human matures
Gametes
◦ Develop from germ cells in
gonads
Ovaries and testes
Sexual Life Cycles
• Alternation of Generations:
– Plants • Most fungi & some protists:
– Some Algae • Gametes fuse yields diploid
• Sporohpyte zygote
– Multicellular diploid
– Meiosis yields haploid spores
• Meiosis occurs w/out
• Spore
multicellular diploid offspring
– Haploid developing
– Divides mitotically yields gametophyte – Meiosis produces haploid cells
• Gametophyte (not gametes)
– Multicellular haploid – Haploid cells divide by mitosis
– Mitosis yields gametes and yield:
• Unicellular decendants or
• Gametes
• Haploid multicellular adult
– Haploid cell fusion yields next
– Mitotically divides and yeilds
sporophyte
gametes
Fig. 13-6
(a) Animals (b) Plants and some algae (c) Most fungi and some protists
Meiosis pgs. 198-199
• Meiosis I:
– Separates Homologous
Chromosomes
• Meiosis II:
– Separates sister
Chromatids
http://www.phschool.com/science/biology_place/labbench/lab3/images/stages2.gif
Unique Components of Meiosis
• Synapsis:
– Replicated homologs pair up and are connected
• Crossing Over:
– Non-sister chromatids exchange pieces of DNA produces
recombinant chromosomes
• Prophase I: increases variation in a population
Unique Components of Meiosis
• Metaphase I:
– Homologs line up on the metaphase plate TETRADS
Unique Components of Meiosis
• Separation of Homologs: Anaphase I
– Sister chromatids stay together
– Replicated homologs move to opposite poles of
the cell
Unique Components of Meiosis
• Telophase I and cytokinesis
– Haploid daughter cells form but with 2 sister chromatids per
chromosome
• Not necessarily genetically identical because of crossing over
Unique Components of Meiosis
• Prophase II –
Telophase II and
cytokinesis
– Sister chromatids line
up then separate to
form chromosomes
– 4 non identical
haploid cells are
produced
• variation
Origins of Genetic Variation
• Independent Assortment
of Chromosomes
– Maternal and paternal
homolog move into
daughter cells of meiosis I
separately
• Crossing Over
– Homologs trade DNA
pieces in Prophase I
• Random Fertilization
– 223 possibilities or 8.4
million for each egg or
sperm, so 223 x 223 yields http://www.scientificamerican.com/media/inline/EB910030-C936-17CB-
7FEDD0F3F1C79CC9_1.jpg
70 trillion possibilities
Mitosis, Cell Cycle vs. Meiosis
Don’t forget the
summary!