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GENESIS OF TWINS
Dizygotic twins
It is also known as binovular or fraternal twins
develop from two separate ova that are
fertilized by two different spermatozoa, and are
often referred to as non- identical twins.
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CONTD…
They are no more alike than any brother or
sister and can be the same or different sex.
Because in any pregnancy there is a 50:50
chance of girl or boy, half of the dizygotic
twins will be boy-girl pairs.
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CONTD…
Sometimes a twin pregnancy just happens. In
other cases, specific factors are at play.
For example, a twin pregnancy is more likely
as women get older because hormonal
changes can cause more than one egg to be
released at a time.
Use of assisted reproductive technologies —
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Monozygotic twins
It is also known as uniovular twins as
‘identical twins.
They develop from the fusion of one ovum
and one spermatozoon, which after
fertilization spills into two.
These twins will be the same sex and have
same genes, blood groups, and physical
features such as eye and hair color, ear
shapes and palm creaases.
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Contd…
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Contd…
If the divisions takes place between the 4th
and 8th day after the formation of inner cell
mass when chorion has already developed –
diamniotic monochorionic twins develop(66 %).
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Contd…
If the division occurs after 8th day of fertilization,
when the amniotic cavity has already formed, a
monoamniotic- monochorionic twin develops (3
%).
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Contd…
on extremely rare occasions, division occurs
after 2 weeks of the development of
embryonic disc resulting in the formation of
conjoined twin (1%) called – Siamese twin.
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Four types of fusion
a. Thoracopagus (most common),
d. Dischopagus (caudal).
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Zygosity and chorionicity
Zygosity refers to the genetic makeup of twin
pregnancy and chrorionicity refers the
placenta's membrane status.
chrorionicity is determined by the timing of
embryo division.
Chorionnicity is diagnosed by
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Diagnosis of zygosity
Examining fetal gender
(different genders=dizygotic), placenta
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Examination of placenta and membrane
Dizygotic twins:
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Contd…
Monozygotic twins:
i) the placenta is single.
There is varying degree of free anastomosis
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Contd…
iii) As such the intervening membranes
consist of two layers of amnion only.
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Contd…
If the fetus are of the same sex and have the
same genetic features (dominant blood
group), monozygosity is likely.
A skin graft: Acceptance of reciprocal skin
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INCIDENCE
The incidence of monozygotic twins is
constant worldwide, approximately four per
1000 births.
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Contd…
The incidence of multiple births increased
significantly in the late 20th century in the
United States and worldwide.
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Contd…
As previously stated, the incidence of
monozygotic twins is constant worldwide
(approximately 4 per 1000 births).
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Contd…
Dizygotic-twin birthrates are also influenced by
other factors, such as parity and mode of
fertilization (i.e. most artificially conceived twins
are dizygotic; however, 6-10% are monozygotic).
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Etiology
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Contd…
1. Race: The frequency is highest amongst
Negroes, lowest amongst Mongols and
intermediate amongst Caucasians.
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Contd…
4. Influence of parity: The incidence is
increased with increasing parity, especially
from 5th gravida onward.
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Contd…
6. Superfetation: it is the fertilization of two
ova released in different menstrual cycles.
The nidation and development of one fetus
over another fetus is theoretically possible
until the decidual space is obliterated by 12
weeks of pregnancy.
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MATERNAL PHYSIOLOGICAL CHANGES
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LIE AND PRESENTATION
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Contd…
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DIAGNOSIS
1. HISTORY:
i. History of ovulation including drugs
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2. SYMPTOMS
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Contd…
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3. GENERAL EXAMINATION
3. Evidence of pre-eclampsia(25%) is a
common
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4. ABDOMINAL EXAMINATION
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Contd…
The height of the abdomen at the level of
umbilicus is more than the normal average
term (100 cm).
Fetal bulk seems disproportionately larger in
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Contd…
Auscultation:
Simultaneous hearing of two distinct fetal heart
sound located at separate spots given a certain
clue in diagnosis of twins, provided the
difference in heart rates is at least 10 beats per
minute.
The abdominal palpation and auscultation
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5.Internal examination
In some cases, one head is felt deep in the
pelvis, while the other one is located by
abdominal examination.
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6. Investigations
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Contd…
5. Fetal abnormalities.
6. Fetal growth monitoring ( at every 3-4
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Chorionicity of the placenta
It is the best diagnosed by ultrasound at 6-9
weeks of gestation.
In dichorionic twins there is a thick septum
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Contd…
This is known as Lambda or twin peak signs.
Presence of lambda or twin peak sign indicates
dichorionic placenta.
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Contd…
Biochemical tests:
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Differential diagnosis
Hydramnious
Big baby
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COMPLICATIONS
Maternal
During pregnancy:
Nausea and vomiting occurs with increased
frequency and severity.
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Contd…
Pre eclampsia (25%) is increased 3 times over
singletone pregnancy.
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Contd…
Antepartum hemorrhage may occur with slight
increased frequency.
The increased incidence of placenta previa is due to
the bigger size of the placenta encroaching on to
the lower segment.
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Contd…
iii. Deficiency of folic acid
iv. Following delivery of the 1st baby due to sudden
shrinkage of the uterine wall adjuncent to the
placental attachment.
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Contd…
Pre term labor(50%) frequently occurs and the
mean gestational period for twins is 37 weeks.
overdestension of the uterus, hydramnios,and
PROM are responsible for pre term labor.
Mechanical distress
palpitation,
dyspnea,
vercisities and
hemorrhoids
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During labor
Early ROM and cord prolapse are increased
due to increased prevalence of
malpresentation.
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Contd…
Prolonged labor it is theoritically expected, is
not practically met.
This is because of parous women with smaller
baby.
Increased operative interference is due to high
prevalence of malpresentation with its
associated compliations.
Bleeding (intrapartum) following the birth of the
1st baby may at times be almaring and is due to
separation of placenta following reduction of
placental site.
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Contd…
Postpartum hemorhage is due to:
i. Atony of the uterine muscle due to
overdistension of the uterus
ii. Longer time taken by the big placenta to
separate
iii. Bigger surface area of the placenta
exposing more uterin sinuses
iv. Implantation of a part of the placenta in
the lower segment
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During pueperium
Subinvolution of uterus , because of bigger
size of uterus
Infection because of increased operative
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Fetal
Miscarriage is increased especially with
monozygotic twins
Premature rate (80%)
Discordant twin growth (25%)
IUD of one fetus is more in monozygotic one.
Fetal anomalies increased by 2-4%
Asphyxia and still birth are common due to
increased prevalence of pre eclampsia
malpresentation placental abruption and
increased prevalence of operative interfrance.
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PROGNOSIS
Maternal mortality is increased in twin than in
singleton pregnancy.
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Contd..
Perinatal mortality is markedly increased
mainly due to prematurity.
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Contd…
One third loss is due to still birth and two
third due to neonatal death.
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COMPLICATIONS OF MONOCHRIONIC
TWINS
Twin- twin transfusion syndrome (TTTS)
It is clinicopathological state, exclusively met
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Contd…
As a result of receptor twin becomes larger
with hydramnios , polycythemic,
hypertensive, and hypervolemic,at the
expense of the donor twin which becomes
smaller with oligohydramnios,
anemic,hypotensive and hypovolemmic.
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Contd…
The donor twin may appear “stuck” due to
severe oligohydramnios.
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MANAGEMENT
Antenatal diagnosis is made by ultrasound with
Doppler blood flow study in the placental
vascular bed.
a. Repeated amniocentesis to control
polyhydramnios in the recipient twin is done.
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Conntd…
d. Selective reduction(feticide) of one twin is
done when survival of both the fetuses is at
risk.
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Contd…
Congenital abnormalities (neural tube
defects, holorosencephaly) are high (2-3
times).
Perinatal mortality in TTTS is about 70%.
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DEAD FETUS SYNDROME
Death of one twin (2-7%) is associated with
poor outcome of the co-twin (25%) specially
in monochorionic placenta.
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TWIN REVERSEED ARTERAL
PERFUSION(TRAP)
It is characterized by an ‘acardiac perfused
twin’ having blood supply from a normal co-
twin via large arterio-arterial or vein to vein
Anastomosis.
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Contd…
The perfused twin is often chromosomally
abnormal.
The anomalous twin may appear an
amorphous mass.
Management of TRAP is controversial.
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Monoamniocity(2% of all twins)
In monochorionic twins leads to high
perinatal mortality due to cord
problems(entanglement).
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Conjoined twins
It is rare (1.3 per 100,000 births).
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Management
Antenatal management:
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Contd…
Advice on following points;
Diet:
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Contd…
Increased rest: Increased rest at home and early
caesarean section is advised to prevent preterm labor
and other complications.
Supplement therapy:
Iron therapy is to be increased to the extent of 60-100
mg per day.
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Contd…
Interval of antenatal visit
It should be more frequent to detect at the
earliest, the evidence of anemia, preterm labor
or pre eclampsia.
Fetal surveillance
It is maintained by serial sonography at every
3-4 weeks interval.
Assessment of fetal growth, amniotic fluid
volume and AFI, non stress test and doppler
velocimetry are carried out.
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Fetal surveillance
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Hospitalization
Routine : routine hospital admission only for
bed rest is not essential.
Bed rest even at home from 24 weeks
babies
ii. Decreased frequency of pre eclampsia
iii. Prolongation of the duration of pregnancy
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Contd…
Use of corticosteroid to accelerate fetal lung
maturation is given to women with pre term
labor less than 34 weeks.
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Mangement during labor
Place of delivery:
As twin pregnancy is considered as ‘high risk’,
the patient should be confined in an equipped
hospital preferably having an intensive
neonatal care unit.
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First stage
A skilled obstetrician should be present.
An around experienced anesthesist should be
made available.
Presence of ultrasound in the labor ward is
helpful.
The patient should be in bed to prevent early
rupture of membranes.
Use of analgesic drugs is to be limited as the
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Contd…
Careful fetal monitoring (preferably electronic) is
to be done.
Internal examination should be done soon after
rupture of membranes to exclude cord prolapse.
An intravenous line with ringer’s solution should
be made readily available.
Neonatologist should be present at the time of
delivery.
Throughout the labor the emotional as well as the
general physical condition of the mother must be
considered.
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Delivery of the first baby
Check presentation
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Contd…
The delivery should be conducted as same in the
normal delivery
As the baby is usually small, the delivery does
points:
i. Episiotomy under local infiltration with 1%
lignocaine.
ii. Perform instrumental delivery, if needed,
should be done preferably under pudendal
block anesthesia.
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Contd…
iii. Clamp the cord at two places and cut in
between to prevent exsanguination of the second
baby through communicating placental circulation
in the monozygotic twins.
Do not attempt to deliver the placenta until the
last baby is required.
iv. At least, 8-10 cm of cord is left behind for
administration of any drugs or transfusion, if
required.
v. The baby is handed over to the circulating
nurse after labeling as number one.
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Conduction of the labor after delivery
of 1st baby
Principles:
The principle is to expedite the delivery of the
second baby is put under strain due to placental
insufficiency caused by uterine retraction
following the birth of the first baby.
Steps of management:
Step i: following the birth of the 1st baby, the lie,
presentation, size and FHS of the second baby
should be ascertained by abdominal examination
or if required by real time ultrasound.
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Contd…
A vaginal examination is also to be made not
only to confirm the abdominal findings but to
note the status of the membranes and to exclude
cord prolapse, if any.
Lie longitudinal:
step i: low rupture of the membranes is done after
fixing the presenting part on the brim.
Syntocinon may be added to the infusion bottle to
achieve this.
Internal examination is once more to be done to
exclude cord prolapse.
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Contd…
Step ii: if the uterine contraction is poor, 5
units of oxytocin is added to the infusion
bottle.
The interval between deliveries should ideally
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Contd…
Vertex: low down- forceps are applied
High up- if the 1st baby is too small and the 2nd
one seems bigger, ruled out CPD.
The possibility of the hydrocephalic head
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Contd…
Breech: the delivery should be completed by breech
extraction.
Lie tranverse:
It should be corrected by external version into
longitudinal lie, preferably cephalic, if fails, podalic
If the external version fails, cx. Is fully dilated and
membranes is still intact attempt internal podalic
version.
If the fetus is small there is no difficulty in
performing internal version and it is the only
accepted indication of internal version in present day
of obstetric practice.
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Indication of urgent delivery of the
2nd baby
Severe (intrapartum) vaginal hemorrhage.
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Management
In all these conditions, the baby should be
delivered quickly.
A rational scheme is given below which
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Contd…
C. Transverse lie: internal version followed by
breech extraction under G.A.
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Management of 3rd stage of labor
The risk of PPH can be minimized by routine
administration of 0.2 mg methargin or 10
unit oxytocin IM with the delivery of the
anterior should of the 2nd baby.
The placenta should be delivered by CCT.
It is a sound practice to continue the oxytocin
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Contd…
The placenta should be examined and the
number of amnion sacs, chorions and
placenta are noted.
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Indication of caesarean section
1. Obstetric cause
Placenta previa
Severe pre eclampsia
Previous caesarean section
Cord prolapse of the 1st baby
Abnormal uterine contraction
Contracted pelvis
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Contd…
2. For twins:
Monozygotic twins
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Dutta,DC: Text Book of Obstetrics,Central
Book agency 8th ed.
Marshall. J and Raynor Myles Textbook for
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