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  • Adrenergic Agonist Effects

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    Dendy
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    This document discusses adrenergic agonists and their effects. It describes how activation of different adrenergic receptors - alpha-1, alpha-2, beta-1, and beta-2 - leads to various physiological responses like smooth muscle contraction, sedation, cardiac effects, and metabolic processes. Specific agonists are also mentioned like norepinephrine, dopamine, dobutamine, ephedrine, vasopressin, and dexmedetomidin and their clinical applications and dosages. References include pharmacology textbooks like Morgan & Mikhail’s Clinical Anesthesiology and Goodman & Gilman’s The Pharmacological Basis of Therapeutics.

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    Adrenergic

    Original Title

    Adrenergic Agonis

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    This document discusses adrenergic agonists and their effects. It describes how activation of different adrenergic receptors - alpha-1, alpha-2, beta-1, and beta-2 - leads to various physiological responses like smooth muscle contraction, sedation, cardiac effects, and metabolic processes. Specific agonists are also mentioned like norepinephrine, dopamine, dobutamine, ephedrine, vasopressin, and dexmedetomidin and their clinical applications and dosages. References include pharmacology textbooks like Morgan & Mikhail’s Clinical Anesthesiology and Goodman & Gilman’s The Pharmacological Basis of Therapeutics.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    5 views16 pages

    Adrenergic Agonist Effects

    Uploaded by

    Dendy
    This document discusses adrenergic agonists and their effects. It describes how activation of different adrenergic receptors - alpha-1, alpha-2, beta-1, and beta-2 - leads to various physiological responses like smooth muscle contraction, sedation, cardiac effects, and metabolic processes. Specific agonists are also mentioned like norepinephrine, dopamine, dobutamine, ephedrine, vasopressin, and dexmedetomidin and their clinical applications and dosages. References include pharmacology textbooks like Morgan & Mikhail’s Clinical Anesthesiology and Goodman & Gilman’s The Pharmacological Basis of Therapeutics.

    Copyright:

    © All Rights Reserved
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    of 16

    ADRENERGIC AGONIST

    Persiapan CBT September 2020


    Bimo Kusumo Bhirowo
    Aktivasi ALPHA-1 RECEPTORS
    1. Mata

    2. Blood Vessel
    KONTRAKSI 3. Uterus
    SMOOTH MUSCLE 4. Gut

    5. Genitourinary
    Bronkokonstriksi
    Menghambat sekresi insulin
    Lipolisis
    Morgan & Mikhail’s
    Clinical Anesthesiology 6th Edition
    ALPHA-2 RECEPTORS

    1. Sedasi
    Aktivasi 2. Mengurangi sympathetic
    outflow
    3. Analgesik

    Morgan & Mikhail’s


    Clinical Anesthesiology 6th Edition
    BETA-1 RECEPTORS

    INOTROPIK
    Aktivasi CHRONOTROPIC
    DROMOTROPIC
    LUSITROPIC
    Morgan & Mikhail’s
    Clinical Anesthesiology 6th Edition
    Aktivasi BETA-2 RECEPTORS

    Relaksasi Glikogenolisis
    SMOOTH MUSCLE Gluconeogenesis
    Insulin release
    Bronkodilatasi
    Vasodilatasi
    Lipolisis
    Relaksasi uterus Morgan & Mikhail’s
    Clinical Anesthesiology 6th Edition
    Morgan & Mikhail’s
    Clinical Anesthesiology 6th Edition
    Stoelting’s
    Pharmacology & Physiology 5th Edition
    Morgan & Mikhail’s
    Clinical Anesthesiology 6th Edition
    Morgan & Mikhail’s
    Clinical Anesthesiology 6th Edition
    Norepinephrine
    Koroner?
    Arteri &
    Vena

    Hipoperfusi

    Preload?

    Stoelting’s
    Pharmacology & Physiology 5th Edition
    Dopamine

    /m nt
    Low Dose c g/ kg
    0,5 - 3m

    / m nt
    c g /k g
    inotrope 10 m
    3- PVR

    /m nt
    g/k g
    vasokonstriksi >1 0 mc

    Stoelting’s
    Pharmacology & Physiology 5th Edition
    Dobutamine

    ta s i
    <5mcg/kg/mnt d il a
    s o
    Va

    5-20mcg/kg/mnt

    Stoelting’s
    Pharmacology & Physiology 5th Edition
    Ephedrine
    Direct &
    Indirect

    Pada kehamilan?
    Anti emetic
    I M
    / kg
    mg
    0, 5
    Stoelting’s
    Pharmacology & Physiology 5th Edition
    Vasopressin
    Receptor?

    Konservasi air

    GI Tract V1 V2
    koagulasi
    Hem
    VWD
    A

    Goodman & Gilman’s 13th Edition


    The Pharmacological Basis of Therapeutics
    Dexmedetomidin
    Alpha2 agonis
    Dose 1mcg/kg/10mnt
    0,2-0,7mcg/kg/jam
    Hypo atau Hyper?

    Goodman & Gilman’s 13th Edition


    The Pharmacological Basis of Therapeutics
    T K
    E A
    R S
    I I
    M H
    A

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