An Assignment

on
Reservoir System of Drug Coating in SRDF

Submitted by,
Submitted to,
Rayhan Ahmed
Dr. Didare Alam Muhsin
Roll no: 1409, Batch 45 Professor
Department of Pharmacy Jahangirnagar University
Savar, Dhaka
Jahangirnagar University
Date: 19/11/2020
Savar Dhaka
 Sustained Release Dosage Form

Sustained release dosage forms(SRDF) are those dosage

forms which are designed to release drug continuously at
sufficiently slow or controlled rate over an extended
period of time to provide prolonged therapeutic effect.

Reservoir systems or devices is a common method under

Barrier principle used in the design of orally administered
SDRF.
 Methods
Common methods employed to develop
reservoir systems/devices Include:
1. Coating
2. Microencapsulation 

1. Coating: A number of reservoir devices can be prepared by applying the

technology of coating which includes:
1. Mixed release coated granules/ pellets
2. Uniform release coated granules/ pellets
3. Microdialysis cells
4. Drug coat of retardant material over placebo pellets .
 Continued...
Mixed release coated granules:
Drug pellets/ granules are divided into 3 to 4 groups. One group is left uncoated to provide
the initial loading dose and the other groups of pellets/ granules are coated to different
thicknesses. The various groups are mixed together and placed in capsules or compressed
into tablets.

Examples of drugs designed as SRDF by this method include Erythromycin, Pancreatin etc.

 Uniform release coated granules / pellets:

In this method, drug granules / pellets are uniformly coated by a retardant material that
slowly release drug over sufficiently prolonged period of time.

Examples of drugs designed as SRDF by this technique include Crystals of ascorbic acid,
Methylprednisolone etc.
 Continued...
 Microdialysis cells:
Drug pellets are coated with a mixture of ethyl cellulose (a water insoluble and pH
insensitive polymer) and sodium chloride particles or some other water soluble
materials (e.g. polyethylene glycol).

Examples of drugs designed as SRDF by this technique are Nitroglycerin,

Propoxyphene, Aspirin etc.

 Drug coat of retardant material over placebo pellets:

The drug is suspended in the coating of retardant material applied onto placebo
pellets. The prepared pellets are placed in capsules. The drug is released by erosion
or rupture of the barrier.

Example of drugs designed as SRDF by this technique is theophylline.