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Introduction
Cleft is a gap in the anatomical structure
Facial clefting is the second most common
congenital deformity (after cleft foot).
Affects 1 in 700 births
Problems are cosmetic, dental, speech,
swallowing, hearing, facial growth,
emotional
incidence
Varies according to geographical location
Incidence is 1:700 live births
Cleft lip and palate is more common in
male then female i.e. 3:2
Isolated cleft palate is more common in
female
Embryology
Primary Palate- Triangular area of hard
palate anterior to incisive foramen to point
just lateral to lateral incisor teeth
– Includes that portion of alveolar ridge and four
incisor teeth.
Secondary Palate- Remaining hard palate
and all of soft palate
Embryology
Primary Palate
– Forms during 4th to 7th week of Gestation
– Cleft of primary palate and lip Results from
failure of mesodermal penetration of the grove
between medial nasal and maxillary process
• Secondary palate
– Forms during 6th to 9th week of gestation
– cleft of secondary palate results from failure of
palatal shelve to fuse with one an other due to
failure of tongue to descend in to oral cavity
Causes
Syndromes related 15%
Isolated (nonsyndromic) 50%
Syndromes are;
pierre robin syndrome
Cleidocranial dysostosis
Treacher Collins syndrome
Mecfee syndrome
Causes
Heredity 30%
Nutritional deficiency
Radiation
Drugs
Hypoxia
Viral infections
Vitamin deficiency and access
Causes
Anemia
Tobacco smoking
Alcohol
Consanguineous marriage
Maternal age
Stress
Risk for cleft lip and palate
Depend upon ;
Number of family members with cleft
Relation with cleft patient
Race
Sex and
Type of cleft
Parent having one child with cleft the risk
for having next is 2—5%
Risk
More then one family member having cleft
the risk increase to 10—12%
Unaffected sibling of a child with cleft has
1% chance to have a child with cleft
Syndrome related patient have 50% chance
of having a child with cleft
Classifications
International approved classification
Group I Cleft of anterior palate
a) Lip uni/bi lateral RT/LFT Total/Partial
b) Alveolus uni/bi lateral RT/LFT total/partial
Wynn operation
Conclusions
Cleft Lip and Palate are common congenital
deformities that often affect speech,
hearing, and cosmesis; and may at times
lead to airway compromise.
The oral surgeon is a key member of the
cleft palate team, and is in a unique position
to identify and manage many of these
problems .