Review of the Side Effects of Commonly Used

Drug in Covid-19 Treatment

Presented By: Farzana Yasmin

Examination Roll No.: 141011
Examination Session: 2014-2015
Department of Pharmacy
Jashore University of Science and Technology.
Jashore-7408, Bangladesh

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 Introduction
Covid 19

A new kind of coronavirus (COVID-19) is now global,

originating in Wuhan, China and now spreading to 140 other
nations, including Japan, Korea and Italy. The World Health
Organization (WHO) has designated COVID-19 to be a
worldwide concern for health causing serious human
respiratory tract infections.

Coronaviruses are a type of virus. There are many different

kinds, and some cause disease. A coronavirus identified in 2019,
SARS-CoV-2, has caused a pandemic of respiratory illness, called
COVID-19.

Covid 19 structure
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 Cell entry mechanism
Stages in the replication of SARS-CoV-2 inside the host cell

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Introduction
Covid 19 variants

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 Aims and objectives
The present study that was arranged to obtain.

C: Side effects
A: Medications of various
B: Efficacy rate.
safety profile. treatment
options.

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Listed Drugs used in the covid-19 Treatment

Medicines Vaccines

 Hydroxy-chloroquine  Pfizer-BioNTech 

 Azithromycin  Moderna’s vaccine

 Remdesivir  Johnson & Johnson

 Lopinavir/favipiravir  Oxford-AstraZeneca

 Corticosteroids  Novavax

 Sputnik-V

 Sinopharm

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Side effects of Hydroxy-chloroquine
Most common side effects Rare side effects

 Loss of consciousness  Cardiomyopathy

 Suicidal behavior  Blindness

 Duodenal ulcer  Spondylitis

 Heart rhythm disorders  Hypogamma-globulinaema

 Hernia

 Nephrosclerosis

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 Side effects of Azithromycin
Most common side effects Rare side effects

 Diarrhea  Abnormal BP
 Nausea  Hypermetropia
 Diarrhea
 Abdominal (belly) pain
 Steven Johnson syndrome
 Vomiting  Infantile hypertrophic pyloric stenosis
 Headache

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 Side effects of Remdesivir
Most common side effects Rare side effects

 Nausea  Transaminitis

 Vomiting  Increase in prothrombin time

 Hypersensitivity reactions

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Side effects of Lopinavir/favipiravir
Most common side effects Rare side effects

 Diarrhea  Thrombocytopenia

 Raised liver enzymes  Kidney failure

 Hyperuricemia  Anemia

 QT prolongation

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 Side effects of Corticosteroids
Most common side effects Rare side effects

 Anxiety  Hyperglycemia

 Sleepiness  Permanent disfiguring

 Panic

 Suicidal behavior

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Most Common Side effects of covid-19 Vaccines 

 Injection site: pain, swelling  Redness at injection site  Insomnia

 Tiredness  Nausea  Injection site itching

 Headache  Vomiting  Allergic reactions such as rash

 Muscle pain  Enlarged lymph nodes or itching

 Chills  Feeling unwell

 Joint pain  Arm pain

 Diarrhea

 Fever

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 Serious Side effects of covid-19 Vaccines 
Manufacturer Vaccine Type Efficacy Serious side effects
name rate
Pfizer- BNT162b2 mRNA 95%  Heart attack,
BioNTech  Temporary one sided facial drooping,
 Allergic reactions
Moderna’s mRNA-1273 mRNA 94.1%  Bell’s palsy,
vaccine  Swelling of the face may occur in
patients who have had facial cosmetic
injections.

Heart attack Bell’s palsy Face swelling 13

 Serious Side effects of covid-19 Vaccines 
Manufacturer Vaccine Type Efficacy Serious side effects
name rate
Johnson & Ad26.COV2.S Viral Vector 72-86%  Guillain barre syndrome
Johnson based

Oxford- AZD1222 Viral Vector 76%  Blood clot

AstraZeneca (ChAdOx1) based  Brain stroke
 Autoimmune Hemolytic anemia

Guillain barre syndrome Venus blood clot Autoimmune Hemolytic anemia

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 Serious Side effects of covid-19 Vaccines 
Manufectur Vaccine Type Efficacy Serious side effects
er name rate
Novavax NVX-CoV2373 Protein 90.4%  In the Phase 1 and Phase 2 studies,
Based there were no severe adverse events
related to the vaccine or the placebo
Gamaleya Sputnik V Viral Vector 91%  Increase HIV symptoms
based  Reduced platelet count
Sinopharm BBIBP-CorV Inactivated 79.34%  Serious nausea
virus  Acute disseminated encephalomyelitis

ADEM 15
 Conclusion

To be obvious: these side effects are an indication of a kicking of the

immune system. They do not indicate that the vaccination &
medicines are insecure. There are currently no severe, long-term
adverse effects linked with the receipt of these vaccinations that are
carefully monitored as their usage increases

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 References
1. https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus
2. https://onlinelibrary.wiley.com/doi/10.1002/jctb.6641
3. https://www.dovepress.com/favipiravir-use-in-covid-19-analysis-of-suspected-adverse-drug-eve
nts--peer-reviewed-fulltext-article-IDR
4. https://www.medicalnewstoday.com/articles/sinopharm-covid-19-vaccine-should-you-worry-ab
out-the-side-effects
5. https://news.uthscsa.edu/frequently-asked-questions-novavax-investigational-covid-19-vaccine-
trial/
6. https://www.medicalnewstoday.com/articles/global-covid-19-vaccine-summary-side-effects?fbcl
id=IwAR3F7NayaZ1HjbkauBV5N8uBB8FfGCQXlkwL2m8tIn41Gs42OuyQ3DAepkc#Currently-auth
orized-COVID-19-vaccines

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THANK YOU