Product of Marine and Fisheries

• Apa itu DHA ?

• Docosahexaenoic acid (DHA)
• Docosapentaenoic acid (DPA)
• Eicosapentaenoic acid (EPA)
• Termasuk 3-n HUFA
• Highly Unsaturated Fatty Acids (HUFA)
• DHA incorporated in lipids,
phosphatidylethanolamine (PE) dan
phosphatidylcholine (PC)
 Pharmacokinetics study ?
• The study of uptake, distribution and excretion of drugs
with respect to time
• The theoretical and mathematical interpretation of time
course of drug concentration in the body
1. Red sea bream, Chrysophrys major, DHA
• Passed the blood brain-barrier
• Distribute and accumulated in the brain
• The absorption and distribution similar in the mamals
and other fishes
• For normal growth the plasma DHA level was suggested
• 21.0 – 40.3 microgram.mL-1 (0.025% of fish body weight
.d-1)
 Other study
2. In rat
• DHA composed of phospholipids
• In the brain
3. In juvenile turbot
• Incorporated (conjugated lipids) into PE, PC and
phosphatidyl serine (PS) and
phosphatidylinositol (PI)
• A deficiency of DHA results in poor development
of the central nervous system and could induce
improper development of learning ability of fish,
including feeding behavior.
 Other study
4. In larval yellow tail, Seriola quinqueradiata
• DHA deficiency inhibit the development of schooling
behavior in their juvenile stage
• Schooling is an anti predator behavior
• DHA is a dominant component of nervous system
5. In Pacific thread fin, Polydactylus sexfilis
• HUFA deficiency has negative impact during
metamorphosis
• Patchiness was formed on day 7-8 posthatch
• HUFA AND high-HUFA groups showed schooling
behavior at 19 day after hatching
• No-HUFA group did not form schooling, high mortality
•
 Other study
6. In humans
• DHA was incorporated in in the
erythrocyte membrane
• Accumulated in the erythrocyte PC and PE
 Omega () tiga ?
• Asam lemak jenuh penamaannya berdasarkan
panjangnya rantai karbon
• 18 : 2  6 artinya mempunyai 18 rantai karbon, 2 ikatan
rangkap, ikatan rangkap pertama terletak pada atom
karbon yang ke 6
 6 dinamakan rangkaian lemak Linoleic (Linoleic
acids) ikatan rangkap yang lebih jenuh dari 3
 3 dinamakan rankaian lemak linolenic (linolenic
acids)
• Hewan darat membutuhkan 3
• Hewan air membutuhkan 6
Kandungan asam lemak 3 dan 6
dalam lemak

Bahan makanan 3 (%) 6 (%)

Minyak ikan 38 4
Minyak kedelai 3 4
Minyak hati ikan sotong 32,3 2,1
(cuttle fish)
Daging sapi - 2