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  • Receptors Used As Drug Target: Receptor

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    Iqbal Hossain Noyon
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    Receptors are proteins that receive signals and transmit them within biological systems. There are several major families of receptors that are commonly targeted by drugs, including ligand-gated ion channels, G protein-coupled receptors, enzyme-linked receptors, and nuclear receptors. Agonists interact with receptors to initiate physiological responses, while antagonists oppose the responses induced by other bioactive agents. Partial agonists are unable to induce maximal receptor activation regardless of dose and demonstrate varying activity depending on both dose and receptor type. Receptors are important drug targets associated with disease processes.

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    Receptors are proteins that receive signals and transmit them within biological systems. There are several major families of receptors that are commonly targeted by drugs, including ligand-gated ion channels, G protein-coupled receptors, enzyme-linked receptors, and nuclear receptors. Agonists interact with receptors to initiate physiological responses, while antagonists oppose the responses induced by other bioactive agents. Partial agonists are unable to induce maximal receptor activation regardless of dose and demonstrate varying activity depending on both dose and receptor type. Receptors are important drug targets associated with disease processes.

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    3 views1 page

    Receptors Used As Drug Target: Receptor

    Uploaded by

    Iqbal Hossain Noyon
    Receptors are proteins that receive signals and transmit them within biological systems. There are several major families of receptors that are commonly targeted by drugs, including ligand-gated ion channels, G protein-coupled receptors, enzyme-linked receptors, and nuclear receptors. Agonists interact with receptors to initiate physiological responses, while antagonists oppose the responses induced by other bioactive agents. Partial agonists are unable to induce maximal receptor activation regardless of dose and demonstrate varying activity depending on both dose and receptor type. Receptors are important drug targets associated with disease processes.

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    Receptors used as drug target

    Introduction
    A drug target is a molecule in
    Receptor Major families of receptor
    the body usually a protein, that Receptors are chemical
    is intrinsically associated with structures, composed of protein,  Ligand gated ion channel
    a particular disease process and that receive and transduce  G protein couple receptor
    that could be addressed by signals that may be integrated  Enzyme linked receptor
    a drug to produce a desired into biological systems.  Nuclear receptor
    therapeutic effect.

    Drug effecting on receptor Antagonist


    Antagonist is a drug or a
    Agonist : Agonist is an endogenous compound that opposes
    substance or a drug that can interact the receptor associated
    with a receptor and initiate a responses normally
    physiological or pharmacological induced by another
    response bioactive agent.
    Example of agonist : Heroin, Examples are naltrexone
    oxycodone, methadone, and naloxone
    hydrocodone, morphine, opium
    Conclusion
    Partial agonist
    agonist opioids activate the opioid receptors in
    Partial agonist is an agonist which is the brain fully resulting in the full opioid
    unable to induce maximal activation of effect.
    Antagonists cause no opioid effect and block
    a receptor population, regardless of the
    full agonist opioids.
    amount of drug applied. Examples of Partial agonist demonstrate varying activity
    partial agonists include buprenorphine, depending on the opioid receptor but also
    butorphanol, and tramadol varying on the dose

    Reference
    D. Cavalla, A. Bender,et al in Comprehensive Medicinal Chemistry III, 2017 Rejwana Islam
     http://n-pharmacology.blogspot.com/2013/06/major-receptor
    "Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th
    2019-3-70-031
    Edition" McGraw-Hill Education / Medical (2017)

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