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  • Inhibitors of ATP: Generation

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    Trần Lan Anh
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    A. Transport inhibitors bind to electron transport complexes and block the transfer of electrons to oxygen, interfering with the ability to create a proton gradient. B. The ATP synthase inhibitor oligomycin binds directly to the ATP synthase enzyme complex and plugs up the H+ channel, blocking ATP formation. C. Uncoupling agents provide an alternate pathway to transfer protons back into the mitochondrial matrix, which dissipates the proton gradient and bypasses ATP formation by the ATPase. Thermogenin is a natural uncoupling protein found in brown fat, hibernating animals, and infants that permits thermogenesis without ATP utilization.

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    Inhibitors-of-ATP-Generation-nhóm-12-2

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    A. Transport inhibitors bind to electron transport complexes and block the transfer of electrons to oxygen, interfering with the ability to create a proton gradient. B. The ATP synthase inhibitor oligomycin binds directly to the ATP synthase enzyme complex and plugs up the H+ channel, blocking ATP formation. C. Uncoupling agents provide an alternate pathway to transfer protons back into the mitochondrial matrix, which dissipates the proton gradient and bypasses ATP formation by the ATPase. Thermogenin is a natural uncoupling protein found in brown fat, hibernating animals, and infants that permits thermogenesis without ATP utilization.

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    3 views15 pages

    Inhibitors of ATP: Generation

    Uploaded by

    Trần Lan Anh
    A. Transport inhibitors bind to electron transport complexes and block the transfer of electrons to oxygen, interfering with the ability to create a proton gradient. B. The ATP synthase inhibitor oligomycin binds directly to the ATP synthase enzyme complex and plugs up the H+ channel, blocking ATP formation. C. Uncoupling agents provide an alternate pathway to transfer protons back into the mitochondrial matrix, which dissipates the proton gradient and bypasses ATP formation by the ATPase. Thermogenin is a natural uncoupling protein found in brown fat, hibernating animals, and infants that permits thermogenesis without ATP utilization.

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    Inhibitors of ATP

    Generation
    Presenters
    Participants Trần Lan Anh
    Nguyễn Thanh Tuấn

    Nhóm 1+2
    Editors
    Nguyễn Vũ Cẩm Quỳnh
    Võ Thị Kiều Oanh
    Lê Tiến Nam

    Content
    Lâm Thị Ánh Ngọc Nguyễn Phương Kiều
    Lê Anh Thư Nguyễn Hoàng An
    Lê Hữu Khải Nguyễn Phước Thịnh
    Lê Ngọc Điệp Nguyễn Thành Minh Phương
    Cao Hoàng Lâm Nguyễn Thị Trúc Linh
    Vương Hồng Phước
    An ATP ATP helps us maintain function of
    cell
    MOLECULE
    Lớp học có thu phí
    Mỗi nghệ sĩ đều có tiềm năng trở thành giáo viên.

    Công nghệ tốt


    Lớp học trực tuyến, hướng dẫn một kèm một - tất cả
    đều khả thi nhờ vào công nghệ tuyệt vời.
    Inhibitors Inhibitor
    A. Transport inhibitors bind to
    one of the electron transport
    complexes and block the transfer
    of electrons to oxygen, thus
    interfering with the ability to
    create a proton gradient

    Transport inhibitors
    Some types
    of inhibitors
    B. The ATP synthase
    inhibitor oligomycin
    binds directly to the enzyme
    complex and plugs up the
    H+ channel, which blocks
    ATP formation.
    C. Uncoupling agents provide an alternate pathway to transfer
    protons back into the mitochondrial matrix, which dissipates the
    proton gradient and bypasses ATP formation by the ATPase
    1. Thermogenin (.1)
    is a natural uncoupler found in the
    mitochondria of brown fat (.2) in
    hibernating animals (.3) and infants
    (.4)

    C.1.2 C.1.1
    C.1.4

    C.1.3

    A. Thermogenin (.1) is a natural uncoupler found


    in the mitochondria of brown fat (.2) in hibernating animals
    (.3) and infants (.4)
    Thermogenin: now known as uncoupling protein 1, or UCP1

    What is Thermogenin?
    Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling
    protein 1, or UCP1) is an uncoupling protein found in the mitochondria of brown adipose
    tissue (BAT). It is a proton transporter and dissipates the proton gradient generated by
    oxidative phosphorylation and diverts energy from ATP synthesis to thermogenesis
    (uncouples the system).
    01 02
    Thermogenin is a membrane protein that Under such conditions, up to 90%
    permits the organism to keep warm of ATP derived from fatty acid
    through metabolism without having to oxidation in these tissues is
    utilize ATP for movement.` expended as heat.
    .

    03 04
    Tích hợp liền mạch Mở lớp ở mọi cấp độ
    Ứng dụng của chúng tôi phù hợp với Nhiều lớp học phù hợp với nhiều trình độ kỹ
    tất cả định dạng, dù là di động, web năng khác nhau.
    hay máy tính bảng.
    2. Chemical agents
    (such as 2,4-dinitrophenol) that
    are able to bind a proton and be
    soluble in the lipid bilayer can also
    act as uncoupling agents.

    Lipid bilayer
    2,4-dinitrophenol
    THANKS FOR
    LISTENING
    Mitochondrial matrix

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