Gram Negative Gram Positive

Two Drug Bugs

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Fragilis – Gut Difficile
Melanogenicus –
Respiratory Anaerobes
Gram Negative Gram Positive

Penicillin
(Pen G, Pen VK)
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Synthetic Penicillins
Ampicillin / Amoxicillin Augmentin / Unasyn
(w/ beta lactamase inhibitor)
Beta Aerobes
Lactamase
Serratia H. Flu
Pseudomonas Salmonella Beta
Klebsiella
Acinetobactor Shigella
Lactamase MRSA
E. Coli
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Synthetic Penicillins
Ampicillin / Amoxicillin Nafcillin /
Methicillin//Dicloxacillin
Aerobes
Serratia H. Flu
Pseudomonas Salmonella Beta
Klebsiella
Acinetobactor Shigella
Lactamase MRSA
E. Coli
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Anti-Pseudomonal Penicillins
Piperacillin
Penicillin Zosyn / Timentin
(Pen G, Pen VK) (w/ beta lactamase inhibitor)
Aerobes
Serratia H. Flu
Pseudomonas Salmonella Beta
Klebsiella
Acinetobactor Shigella
Lactamase MRSA
E. Coli
Citrobactor Proteus
Mirabilis Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Spotty lines mean spotty coverage, look up individual coverages for
SPACE bugs other than Pseudomonas
Gram Negative Gram Positive
First Generation Cephalosporins
Cephalexin, cefazolin, cefadroxil
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Second Generation Cephalosporins
Cephalexin, cefazolin,
Cefuroxime, Cefotetan,cefadroxil
cefoxitin
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Cefoxitin and Cefotetan only

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Third Generation Cephalosporins
Cephalexin, Cefotaxime,
Ceftriaxone, cefazolin, cefadroxil
Cefdinir
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor
Ceftazidime

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Fourth Generation Cephalosporins
Cephalexin,
Cefipime (Maxipime)
cefazolin, cefadroxil
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Carbapenems
Meropenem, Imipenem, Ertapenem
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor
Ertapenem= No Pseudomonas

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Monobactams
Aztreonam
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Aminoglycosides
Gentamicin, Tobramycin, Amikacin
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Carbapenems
Meropenem, Imipenem, Ertapenem
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor
Ertapenem= No Pseudomonas

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive
Simple Fluroquinolones
Cephalexin, cefazolin,
Ciprofloxacin, Ofloxacin,cefadroxil
Norfloxacin
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor
Ciproflxoci9n best FQ for Pseudomonas

Bacteroides Oral Anaerobes Clostridium

Difficile
Anaerobes

Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma

Gram Negative Gram Positive
Simple Fluroquinolones
Cephalexin, cefazolin,
Ciprofloxacin, Ofloxacin,cefadroxil
Norfloxacin
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor
Ciproflxoci9n best FQ for Pseudomonas

Bacteroides Oral Anaerobes Clostridium

Difficile
Anaerobes

Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma

Gram Negative Gram Positive
“Respiratory” Fluroquinolones
Cephalexin,
Levofloxacincefazolin, cefadroxil
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor
**

Bacteroides Oral Anaerobes Clostridium

Difficile
Anaerobes

Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma

** Resistance develops quickly
Gram Negative Gram Positive
“Broad Spectrum” Fluroquinolones
Cephalexin,
Moxifloxacin
cefazolin, cefadroxil
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile
Anaerobes

Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma

** Resistance develops quickly
Gram Negative Gram Positive
Macrolides
Cephalexin, cefazolin,
Eythromycin, Clarithromycin,
cefadroxil
Azithromycin
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Macrolides also cover atypicals like Chlamydia, Legionella and Mycoplasma,

Toxoplasmosis
Gram Negative Gram Positive
Ketolides
Cephalexin,
Telithromyicin
cefazolin, cefadroxil
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Macrolides also cover atypicals like Chlamydia, Legionella and Mycoplasma,

Toxoplasmosis
Gram Negative Gram Positive
Tetracyclines
Cephalexin, cefazolin,
Tetracycline, Doxycycline,
cefadroxil
Minocycline
Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella CA- MRSA
StaphMRSA MRSE
Citrobactor
Strep VRE
Enterobactor

Moderate Activity against anerobes

Bacteroides Oral Anaerobes Clostridium

Difficile
Lots of Resistance!!

Tetracyclines also cover atypicals like Chlamydia, Legionella and Mycoplasma,

Gram Negative Gram Positive
Tigecycline

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Tigecylcine also covers atypicals like Chlamydia, Legionella and Mycoplasma,

Gram Negative Gram Positive
Trimethoprim / Sulfa

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella CA- MRSA
Strep Staph MRSA MRSE
Citrobactor
VRE
Enterobactor
Klebsiella/E coli resistance increasing

Bacteroides Oral Anaerobes Clostridium

Difficile

First Line drug for Community Acquired MRSA

Also covers Pneumocystis Carinii
Gram Negative Gram Positive
Vancomycin

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella CA- MRSA
Strep Staph MRSA MRSE
Citrobactor
VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile
Gram Negative Gram Positive
Clindamycin

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella CA- MRSA
Strep Staph MRSA MRSE
Citrobactor
VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile
Gram Negative Gram Positive
Metronidazole

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella CA- MRSA
Strep Staph MRSA MRSE
Citrobactor
VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Also Covers Trichomonas

Gram Negative Gram Positive
Daptomycin
Linezolid

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella CA- MRSA
Strep Staph MRSA MRSE
Citrobactor
VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile
Gram Negative Gram Positive

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes
Gram Negative Gram Positive

Aerobes
Serratia H. Flu
Pseudomonas Klebsiella Salmonella
Acinetobactor E. Coli Shigella MRSA
Citrobactor
Strep Staph MRSE VRE
Enterobactor

Bacteroides Oral Anaerobes Clostridium

Difficile

Anaerobes