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communicable diseases
Chronic Non-communicable diseases (NCDs)
Comprising all impairments or deviations from normal, which have one or more
of the following characteristics:
1. Are permanent
2. Leave residual disability
3. Are caused by non-reversible pathological alterations
4. Require special training of the patient for rehabilitation
5. May be expected to require a long period of supervision, observation or care
2020
NCD burden in India
Total No. of deaths due to NCD per 100000 population
571
782 Males
Females
Key factors
Key factors responsible for a NCDs morbidity and premature
mortality are:
1. Cigarette use and other forms of smoking
2. Alcohol abuse
3. Failure or inability to obtain preventive health services-
HT control, cancer detection & management of diabetes
4. Life-style changes- diet, physical activity
5. Environmental risk factors-occupational hazards,
pollution, destructive weapons
6. Stress factors
NCDs- control & prevention
Challenges:
1. Absence of a known agent
2. Multifactorial causation
3. Long latent period
4. Indefinite onset
Prevention:
5. Mix of interventions (multifactorial)
6. Tertiary prevention- earlier days
7. Identification of risk factors- health promotion activities-
primary prevention
Steps in prevention
1. Case finding –screening health examination technique
2. Application of improved methods of diagnosis, treatment and
rehabilitation
3. Control of food, water and air pollution
4. Reducing accidents
5. human behavioural and lifestyle changes
6. Intensive education
7. Upgrading standards of institutional care and
8. Developing and applying better methods of comprehensive
medical care including primary healthcare
9. Political approaches like ban on smoking, alcohol and drug abuse
Holistic approach-integrated approach
Cardiovascular Diseases (CVD)
Group of diseases of the heart and the vascular system
which are-
• Coronary heart disease/Ischemic heart disease (IHD)-
disease of the blood vessels supplying the heart muscle
• Hypertension
• Cerebrovascular disease (Stroke)-disease of the blood
vessels supplying the brain
• Congenital heart disease- malformations of heart
structure existing at birth
• Rheumatic heart disease (RHD)- damage to the heart
muscle and heart valves from rheumatic fever, caused by
streptococcal bacteria
Problem statement
• CVDs are the number one cause of death globally: more people die annually from CVDs than
from any other cause .
• An estimated 17.3 million people died from CVDs in 2008, representing 30% of all global
deaths. Of these deaths, an estimated 7.3 million were due to coronary heart disease and 6.2
million were due to stroke.
• Low- and middle-income countries are disproportionally affected: over 80% of CVD deaths
take place in low- and middle-income countries and occur almost equally in men and women.
• The number of people who die from CVDs, mainly from heart disease and stroke, will
increase to reach 23.3. million by 2030. CVDs are projected to remain the single leading cause
of death.
Risk factors:
1. Tobacco use
2. Inappropriate diet and
3. Physical inactivity
4. Biological factors
– Overweight
– Central obesity
– High blood pressure
– Dyslipidemia
– Diabetes
– Low cardio-respiratory fitness
Coronary heart disease (ischemic heart disease)
Impairment of heart function due to inadequate blood flow to
the heart compared to its needs, caused by obstructive
changes in the coronary circulation to the heart
25-30 % of deaths in most industrialized countries
WHO- Modern epidemic- a disease that affects populations,
not an unavoidable attribute of ageing.
Manifestation as:
1. Angina pectoris of effort
2. Myocardial infarction
3. Irregularities of the heart
4. Cardiac failure
5. Sudden death
Measurement of burden of disease
1. Proportional mortality ratio
2. Loss of life expectancy
3. CHD incidence rate
4. Age-specific death rates
5. Prevalence rate
6. Case fatality rate
7. Measurement of risk factor levels
8. Medical care
Risk factors/aetiology of CHD
2. Hypertension:
HT accelerates atherosclerotic process
3. Serum cholesterol:
Triangular relationship between habitual diet, blood cholesterol, lipoprotein levels and CHD
Cholesterol/HDL ratio = <3.5 (goal for CHD prevention)
Smoking cessation
Dietary changes Control of HT &
Traditional eating diabetes
Smoking cessation
pattern Healthy nutrition
Blood pressure
Life style practices Exercise promotion
Physical activity
Risk factor Intervention Trials
Framingham Study- 1951, prospective study
study establishing the nature of CHD risk factors and their
relative importance-
Risk Factors Intervention
12
Rule of Halves:
1. The whole community 34
2. Normotensive subjects
3. Hypertensive subjects 56
4. Undiagnosed hypertension
78
5. Diagnosed hypertension
6. Diagnosed but untreated
7. Diagnosed and treated 9
8. Inadequately treated
9. Adequately treated
Risk factors for HT
• Age • Obesity
• Sex • Salt intake
• Genetic factors • Saturated fat
• Ethnicity • Dietary fibre
• Alcohol
• Physical activity
• Environmental stress
• Socio-economic status
• Other factors
Prevention of HT
Primary Secondary
Morphological abnormalities:
Stenosis, occlusion or rupture of arteries
Symptoms:
Coma, hemiplegia, paraplegia, monoplegia, multiple paralysis, speech disturbances, nerve
paresis, sensory impairment.
Stroke includes:
• Subarachnoid haemorrhage
• Cerebral haemorrhage
• Cerebral thrombosis or embolism
• Occlusion of pre-cerebral arteries
• TIA (>24 hours)
• Ill-defined cardiovascular disease
Stroke control programme
1. Control of arterial hypertension
2. Control of diabetes,
3. elimination of smoking
4. Prevention, management of other risk factors
5. Primary prevention through community
health action.
Rheumatic Heart Disease (RHD)
• Rheumatic fever- febrile disease affecting
connective tissues esply., in the heart and joints
initiated by infection of the throat by group A
beta hemolytic streptococci.
• Though it is not a communicable disease but it
results from a communicable disease
(streptococcal Pharyngitis)
• Rheumatic fever RHD (crippling disease)-
continuing damage to the heart, increasing
disabilities, repeated hospitalization, premature
death (<35 years)
Problem statement
2. Host factors:
Age: Childhood 5-15 years (juvenile mitral stenosis)
Sex: affects both sexes equally
Socio-economic status: poverty, overcrowding, poor housing
conditions, inadequate health services, inadequate expertise
of healthcare providers , low level of awareness of the
disease
High-risk groups: school-age children (5-15 years), slum dwellers,
closed community groups
Prevention
1. Primary prevention: Identification of sore throat patients
(children) with streptococcal infection and treating them
with penicillin, target group- 5-15 years treated as High-risk
groups and kept under surveillance for streptococcal
pharyngitis, throat swab of all sore throat cases and treat
with penicillin or erythromycin
2. Secondary prevention: in developing countries identifying
those who have had RF and giving them one IM injection of
benzathine benzyl penicillin at intervals of 3 weeks
continued for 5 years and until the child reaches 18 years of
age (long-term)
3. Non-medical measures: improving living conditions, breaking
the poverty-disease-poverty cycle.
Cancer
Group of diseases characterized by:
• Abnormal growth of cells
• Ability to invade adjacent tissues and even distant organs
• Eventual death of the affected patient if the tumor has progressed
beyond that stage when it can be successfully removed.
Categories:
1. Carcinomas- arising from epithelial cells
2. Sarcomas-arising from mesodermal cells (connective tissue)
3. Lymphomas-arising from cells of bone marrow and immune system
Types:
1. Primary tumor-cancer in the organ of origin
2. Secondary tumor- cancer that has spread to regional lymph nodes
and distant organs.
Problem statement
• Affects all communities in the world
• 10 million people are diagnosed with cancer
• > 6 million die of cancer disease every year
2. Genetic factors:
Mongols – leukaemia common
Cancer Control
Cancer Control
Control of tobacco,
alcohol consumption
Personal hygiene
Cancer Registration-
Radiation
Hospital based
Occupational exposures
Registries,
Immunization
Population based
Foods, drugs and
Registries
cosmetics
Early detection of
Air pollution
cases
Treatment of
Treatment
precancerous lesions
Legislations
Cancer education
Cancer Screening
• Search for unrecognized malignancy by means of rapidly applied tests
• Three purpose:
1. Malignant disease is preceded for a period of months or years by a
premalignant lesion, removal of which prevents subsequent
development of cancer
2. Most cancers begin as localized lesions and if found at this stage a
high rate of cure is obtainable
3. As much as 75% of all cancers occur in body sites that are accessible.
Screening for cancer cervix, breast cancer and lung cancer done
routinely.
Oral Cancer
• One of the ten most common cancer in the world.
• India Males: 12.48 females: 5.52 per 100000
Causes:
1. Tobacco
2. Alcohol
3. Pre-cancerous stage
4. High-risk groups-tobacco chewers, smokers, bidi smokers, people using tobacco
in other forms such as betel quid, and sleeping with tobacco quid in the mouth
5. Cultural patterns: smoking (bidi, chutta, hookah, snuff inhalation, reverse
smoking of cigar.
Prevention:
Primary- habit elimination through health education and motivation for lifestyle
changes supported by legislative measures.
Secondary- early detection (primary health workers especially village guides and
multi-purpose workers), surgery and radiotherapy.
Cancer of the cervix
• Second most common cancer among women worldwide 524000 new cases in 1995.
• Developing countries- 80% of cases
Normal epithelium dysplasia cancer in situ invasive cancer
HPV possible cause through sexual transmission
Risk factors:
1. Age: 25 to 45 years of female
2. Genital warts: possible earlier warts predisposing factor
3. Marital status: widowed, divorced, multiple sexual partners
4. Early marriage
5. Oral contraceptive pills
6. Socio-economic status: common in lower strata of the society
Risk factors:
1. Age: 35-50 years of age
2. Family history: greater chances if positive family history
3. Parity: age at women bear the first child, marital status, no. of children, etc.
4. Age at menarche and menopause
5. Hormonal factors: elevated estrogen and progesterone high risk
6. Prior Breast biopsy: increases risk
7. Diet: high fat diet and obesity
8. Socio-economic status: common in higher socio-economic groups
9. Others: radiation, oral contraceptives, etc.
Prevention:
Primary prevention- elimination of risk factors, strenuous physical activity, reducing
fat intake.
Secondary Prevention: Breast screening, early diagnosis, follow-up,
Lung Cancer
• Industrial workers more prevalent
• Cigarette smoking
• 6.8 % of all malignancies in India
Age: <65 years
Risk factors:
1. Smoking
2. Other factors: air pollution, radioactivity, occupational exposure to asbestos, arsenic
chromates, particles containing polycyclic aromatic hydrocarbons and nickel-bearing
dusts.
Prevention:
Primary Prevention-
Public information and education
Legislative and restrictive measures
Smoking cessation activities
National and international coordination
Secondary Prevention-
Early detection of cases, proper treatment
Chest x-ray and sputum cytology
Stomach Cancer
World’s second most common cancer with over
1 million new cases every year.
High-risk areas include- Central and South
America and Eastern Asia and also Japan
Decreasing incidence attributed to:
Improved food preservation practices, better
nutrition more rich in vitamins from fresh
vegetables and fruits, less consumption of
preserved, cured and salted foods.
H.Pylori contributes to the risk
Diabetes Mellitus
• Not a single disease but heterogeneous group of diseases characterised by state
of chronic hyperglycemia, resulting from a diversity of aetiologies, environmental
and genetic, acting jointly.
• Underlying cause: defective production or action of insulin (hormone controlling
glucose, fat and amino acid metabolism)
• Long-term disease with variable clinical manifestations and progression
• Leads to cardiovascular, renal, neurological ocular and others such as
intercurrent infections.
Classification of DM:
1. Diabetes mellitus
• Insulin dependent DM (IDDM type I)
• Non-insulin dependent DM (NIDDM type II)
• Malnutrition-related DM (MRDM)
• Other types (secondary to pancreatic, hormonal, drug-induced, genetic and other
abnormalities
2. Impaired Glucose tolerance (IGT)
3. Gestational diabetes mellitus (GDM)
Problem statement
• Diabetes is an iceberg disease
• 150 million cases of diabetes worldwide
• Predicted to be doubled by 2025 with greatest no.
in China and India
• Previously disease of middle aged and elderly but
now all age groups –productive period of lives,
burden, economic implications, cost of treatment,
life expectancy, chronic complications of DM
• Associated with industrialization and socio-
economic development-population growth, age
structure, urbanization.
Epidemiological factors
Agent: insulin deficiency-
1. Pancreatic disorders-inflammatory, neoplastic and others such as cystic
fibrosis
2. Defects in the formation of insulin
3. Destruction of beta cells-viral infections, chemical agents
4. Decreased insulin sensitivity,
5. Genetic defects
6. Auto-immunity
Host factors:
Age: any age, NIDDM –middle age
Sex: varies with countries
Genetic factors: strong genetic component
Immune mechanism:
Obesity: central adiposity, increased BMI
Maternal diabetes
Epidemiological factors
Environmental risk factors:
1. Sedentary lifestyle
2. Diet-high saturated fat intake
3. Dietary fibre- intake reduces incidence of DM
4. Malnutrition-PEM in early infancy and childhood leads to
failure of Beta cell function
5. Alcohol
6. Viral infections- rubella, mumps, human coxsackie virus B4
7. Chemical agents: alloxan, streptozotocin, VALCOR,etc.
8. Stress-surgery, trauma, stress of situations, internal or
external
9. Other factors: social factors, etc.
Prevention and control
Screening for diabetes:
Urine examination
Blood sugar testing,
Target population-high-risk group->40 years, f/h of diabetes, obese,
women, patients with premature atherosclerosis
India:
Annual incidence of 2 million cataract induced blindness
3 million eyes need cornea transplantation
Prevalence of blindness in population 50 years and above to be about 8.5 % and
general population about 1.1 %.
Causes of blindness:
Developed countries: Accidents, glaucoma, diabetes, vascular diseases, cataract and
degeneration of ocular tissues (retina, hereditary conditions)
SEAR: Cataract, Vit A deficiency, glaucoma, age-related macular degeneration, diabetic
retinopathy, corneal ulcer and ocular trauma.
Childhood blindness: xerophthalmia, congenital cataract, congenital glaucoma and
optic atrophy due to meningitis, retinopathy of prematurity, uncorrected refractive
errors.
Epidemiological determinants
1. Age: 30 % of blind in India are said to lose their eyesight before they
reach the age of 20 years and < 5 years of age.
2. Children: Refractive errors, trachoma, conjunctivitis, malnutrition
3. Young age group: cataract, refractive errors, glaucoma and diabetes
4. Accidents and injuries-all age groups
5. Sex: higher prevalence in females than males.
6. Malnutrition: Vit. A deficiency, PEM
7. Occupation: workers in industries exposed to dust, injuries, gases,
fumes, flying objects, radiation (welding flash), electrical flash.
8. Social class: More prevalent in low socio-economic class
9. Social factors: quacks, ignorance, poverty, low standard community
and personal hygiene, inadequate health services.
Concepts in eye care
1. Primary eye care: inclusion of eye care in primary health care
2. Epidemiological approach: studies at population level-incidence, prevalence and risk factors
3. Team concept: eye specialist and auxiliary health personnel, health guides, ophthalmic assistants, multi-
purpose workers, voluntary agencies.
4. Establishment of national programmes: National programme for the control of blindness-goal was to reduce
blindness in the country to 0.3 percent by year 2000.
National and international agencies: National Association for the Blind (NAB), Royal Commonwealth Society for
the Blind, International Agency for prevention of blindness