Umbilical Cord Stem Cell Banking

UNDERSTANDING YOUR CHOICES

Cell smallest functional unit in human body. Stem Cells are MASTER CELLS. Unspecialized cells >> can specialize into 200 different cell types. Make up the babys heart, lungs, blood, skin, liver & other organs. Ability to self-multiply. Bodys natural repair system.

Types

Umbilical cord blood largely contains Hematopoietic Stem Cells Mesenchymal cells can be obtained from: Cord tissue

Residual blood in the baby s umbilical cord after birth is cord blood It s a high concentration of special type of cells called stem cells

Importance of Umbilical Cord Blood

Stemcell Cryo-Bag Cryo-

Umbilical Cord Blood Uses

Blood cancer Thalassemia Sickle Cell Disease Inherited disorders Stem Cell disorders Platelet disorders Immune disorders
OVER 75 BLOOD DISORDERS

T-Cell Lymphoma

Importance of Cord Tissue

Collection Tube with Cord Piece

Removal of Blood Vessels from Cord

Culture of MSC s from Umbilical Cord

THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELLS MSCs(CORD TISSUE)

Over 50 clinical trials have been initiated worldwide using MSCs to evaluate their safety and efficacy for treatment of diseases such as
Graft vs. Host Disease Crohns Disease Juvenile Diabetes Congestive Heart Failure COPD Articular Cartilage Defects Acute Myocardial Infarction Multiple Sclerosis Phase III Phase III Phase II Phase II Phase II Phase II Phase II Phase I / II

History 1972 1988 1992

97 Cord Blood Banks in USA. 4 US states where CBB is mandatory.

First unrecorded cord blood transplant in New Jersey Leukemia First recorded transplant in France Fenconi's Anemia Worlds first Cord Blood Stem Cell Bank set-up In Florida, USA CRYO CELL INTERNATIONAL

In 20 years, applications increased from 1 to 75 life-threatening diseases. Over 15,000 successful transplants.

New England Journal of Medicine

Advancements in Cord Blood Stem Cells 1988 Diseases treatable with Cord Blood Number of cord blood transplants Number of families who banked cord blood Odds of being diagnosed with a disease that is treatable with cord blood stem cells, by age 50 1 1 1 in 300,000 2006 75 6,000 400,000 1 in 100 2020 ? ? ? ?

The Vision for Stemcell Therapies for Neurological Disorders

Brain and spinal cord injury. Stroke. Neurodegenerative diseases

Parkinsons Disease Huntingtons Disease Alzheimers Disease Multiple Sclerosis Lou Gerhigs Disease (ALS)

Real case of Cord Blood Transplant?

Has a bit of his brother inside him. Has conquered Thalassemia, March 2009 A vital day Apollo Hospital , Chennai

August 2005 August 2005 September 2005 October 2005 January 2006 April 2006

Diabeties (type 1) Anoxic Brain Injury Paralysis Acute Myeloid Leukemia Neuroblastoma Cerebral Palsy

Autologous Autologous Nephew Sibling Autologous Autologous

Shands Hospital, Florida Duke University Medical Centre North Carolina Aguascalientes, Mexico Chennai, India Vanderblit University, Tennessee Duke university Medical center, North Carolina

May 2006 June 2006 September 2006 September 2006 January 2007 March 2007

Diabeties ( Type 1 ) ALL Cerebral Palsy Thalassemia Ischemic Brain Injury Sepsis following Liver Transplant

Autologous Sibling Autologous Sibling Autologous Autologous

Shands Hospital, Florida ISSSTE Hospital, Mexico Duke university Medical Center, North Carolina Siriraj Hospital Medical Center, Bankok Duke university Medical Center, North Carolina Medical College of Virginia, Virginia

April 2007 May 2007

Thalassemia Major Thalassemia Major

Sibling

Sterling Hospital, Ahmedabad Mount Elizabeth Hospital, Singapore Apollo Speciality Hospital, Chennai Shands Hospital, Florida Medical City Childrens Hospital, Texas Hospital Juan I , Menchaca

Sibling

October 2007 November 2007 December 2007 January 2008

Thalassemia Major Diabetes ( Type 1 ) Neuroblastoma Acute Myeloblastic Leukemia

Sibling Autologous Autologous Sibling

June 2008 August 2008

Cerebral Palsy Sickle Cell Anemia

Autologous Sibling

Duke university Medical Center, North Carolina North Shore Long Island Jewish Childrens Hospital Appollo Hospital, Chennai

August 2008

Chronic Myeloid Leukemia

Sibling

February 2009

Thalassemia Major

Sibling

Duke University Medical Center, North Carolina Apollo Hospital, Chennai

March 2009

Thalassemia Major

Sibling

ABOUT LIFECELL
Established in 2004, LifeCell is today India s largest stem cell bank with presence in over 65 cities and with more than 35,000+ clients Its quality systems have been accredited by organizations such as DGCI,ISO,AABB,CAP,USFDA,DSIR,Etc. Dedicated stem cell company offering complete portfolio of services including R&D, Multi-Service Banking, Therapy, and Clinical Research Technology partnerships with industry leaders such as Cryo-Cell International, and Harvest Therapeutics

Lifecell International Private Limited About the Promoter

Lifecell has been promoted by the Promoter of Shasun Chemicals Limited(www.shasun.com), a Chennai based Rs.500 crore pharma & biotech company. Shasun is a widely respected company which has been in business since 1976, and is also listed on the NSE & BSE. Shasun has three facilities in India and two in UK. Shasun is one of the largest producers of Ibuprofen worldwide. The company offers derivatives of Ibuprofen like Ibuprofen Sodium, Ibuprofen Lysinate and S+Ibuprofen. It is also one of the major producers of Ranitidine and Nizatidine in the world. Its products are exported to countries across North America, Europe, Asia and Latin America.

AABB Accreditation The AABB (American Association of Blood Banks) Accreditation Program strives to improve the quality and safety of collecting, processing, testing, distributing and administering blood and blood products. It assesses the quality and operational systems in place at the cord blood banking facility and ensures it's compliance with Standards, Code of Federal Regulations and federal guidance documents.This independent assessment of a facility's operations helps the facility to prepare for other inspections and serves as a valuable tool to improve both compliance and operations. AABB Accreditation is usually granted for collection, processing, testing, distribution and administration of blood and blood components; hematopoietic progenitor cell activities; cord blood activities; perioperative activities; parentage testing activities; immunohematology reference laboratories and SBB schools.

The Research and Development division of LifeCell has been recognized by the Department of Scientific and Industrial Research (DSIR), Govt. of India. This certification endorses our adherence to research protocols and processes has been formally recognized by the Govt. Moreover this certification serves as a boost to promote further research in Stem Cell and to collaborate with other national institutions of excellence.

It was a team of 7 Doctors from College of American Pathologists (CAP) to test and certify our quality practices. The accreditation certified is called CAP Accreditation in terms of the authority on certification they provide on the Pathological Tests ,like Haematology, Microbiology, Serology and Flow Cytometry which ensures reliability of results and superior customer care. The distinguished team had an interaction with the Heads of the department as well as the Technologists while scrutinising the Standard Operating Procedures, posters, safety and most importantly the competencies of the Staff as well as their continuous training.Now, the great news is that, the CAP Auditors were impressed with our quality of service and practices.

US FDA Standards The United States Food & Drug Administration (US FDA) is the largest governmental regulatory body responsible for the protection of public health. During the early years of cord blood banking, the only regulation that the FDA imposed was mandatory screening for certain diseases such as HIV. But since 2005, the US FDA has framed a full body of regulations outlining the procedures and methods that banks and laboratories must follow. These regulations cover the appropriate collection, processing, packaging, labeling and distribution of cord blood stem cells. In the United States, it is therefore mandatory for all cord blood banks to adhere to the FDA's regulations, which ensure the safe handling and storage of cord blood stem cells. And when a cord blood bank also has AABB Accreditation, it is further evidence of the bank's commitment to quality.

Features of Lifecell International Pvt.Ltd.

                 

First Stem Cell Company who started the concept in India with Technology Partner Cryo-cell Inc. First Stem Cell Company to get ISO 9001-2000 certificate First Stem Cell Company to get the prestigious accreditation from AABB First Stem Cell company to get the DSIR recognition of In-House R&D Unit First Stem Cell Company to own its own Transplant & Clinical Trials Cenmte TRICell First Stem Cell Company to get the prestigious registration USFDA CGMP & CGLP Fitted with a central monitoring system which monitors Temperature, Humidity and Pressure. Class 100 Clean Room with 0.3 Micron HEPA Filters Confirms to USFDA Standards Unique LIMS to track samples after storage UN 3373 Certification for Collection Kit Box 3 Unique ID s for every sample stored ( Customer ID, Lab ID& Sample ID ) Total Sample preserved 30,000+ We already provided 18 samples to our clients for the Transplant 5 Lac Insurance for Stemcell Transplant for the particular child anywhere in India 10 Lac will be provided in the event if the Stemcell not ingraft in the Body. Worldwide free retrieval NBS for 101+ Genetic Disorders

Process of Stem Cell Banking

Registration

KitBox Delivered

Call 24*7 to Lifecell For Sample Collection

Sample Despatch to Lab Through Bluedart/JetAirways

Paramedic Staff Will Collect the Sample

Processing of Sample

Report Despatched after 45days