The premium HA Filler

CLEVIEL Contour
CLEVIEL Prime

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 Are You Losing
Volume in Your
Face?
As we age, our skin’s collagen and
hyaluronic acid that provide
structure to your skin tend to
decrease, leading to volume loss in
face.

Volume is lost in many areas of the

face as we get older.
A youthful face has an inverted tringle
shape
due to contoured areas with volume.

Find your inverted

triangle with CLEVIEL to
restore volume to facial
features.
.

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 What is CLEVIEL?

The Ideal Dermal Filler for you with

- the main ingredient of High concentration quality HA
- a lower level of chemical cross-linker (less than 1%)
- the exclusive patented technology
for outstanding high elasticity and cohesiveness
- the longer expected duration of results

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3 /20
 Which CLEVIEL do I need?

Smooth Lift & Contour

Deep wrinkles (Nose & Chin)
(Nasobasial
folds, foreahead)

Lift & Volume

(Cheeks)

CLEVIEL Contour is the filler with high cohesiveness and

elasticity optimized for areas such as nose and chin where
the shape is easily deformed.

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 ㆍ
Formulation Comparison
<Contour>
High concentration HA
High Elasticity
HA 50mg + 0.3% lido High Cohesiveness
1ml Least shape deformation
after injection.
26G 12mm
Specialized for nose
and chin contouring.

<Prime>

Softer Formulation
Soft Injection Force
HA 33mg + 0.3% lido
Specialized for smoothing
1ml x 2 deep wrinkles including
27G 12mm nasobasial folds.

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 Typical shape variation of nose filler, “Avatar nose”

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 CLEVIEL Contour optimized for Nose & Chin

High
Nose &
Chin Maximized
Concentration
HA (50mg) Contouring duration

High Prevent
Elasticity Spreading
High
Cohesiveness

※Elasticity: Ability to support the skin and maintain its shape.

※Cohesiveness: Ability to adhere to the skin to avoid bumpiness after injection.

CLEVIEL Contour is the best dermal filler to maintain post-treatment shape.

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7 /20
 NEW STANDARD FOR FILLER SELECTION

High concentration & purity HA

with a lower chemical cross-linking rate

4L Crosslinking Technology

Effective lifting – high elasticity & cohesiveness

Gel design with uniform consistency

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 Feature 1. High concentration & purity HA with a lower chemical cross-linking rate

CLEVIEL Grade Level:

Endotoxin
< 0.012 EU/mg (ultra high purity)
Ophthalmic Ophthalmic Medicine
HA Fillers

Bacterial
< 0.05 EU/mg 2) < 0.5 EU/mg 2)
Medicine Endotoxins

Product CLEVIEL Other HA Fillers

Cosmetics
The common fillers use a ‘medical’ grade HA,
but CLEVIEL uses a higher purity ‘ophthalmic’ grade HA only.
Hyaluronic Acid Grade

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Feature 1. High concentration & purity HA with a lower chemical cross-linking rate

• CLEVIEL contains up to of 50mg/ml biocompatible high purity HA.

• It has high elasticity and cohesiveness, showing definite results favored by Asians.
• CLEIVEL achieved a dense and firm gel through physical crosslinking of high concentrate HA while
maintaining the chemical crosslinking rate less than 1%.

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 Ideal HA gel Common HA gel* CLEVIEL’s HA gel

100% Crosslinked Crosslinked < Pendant Crosslinked > Pendant

Crosslinked BDDE
Pendant BDDE
Unreacted BDDE * 50~80% of BDDE binding to HA is pendent type (Dermatol. Surg. 2009, 35, 302-312

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 Feature 2. 4L Cross-Linking Technology

Low Low
Temperatur Swelling
e

Long
Low BDDE
Duration
CLEVIEL

• Thanks to CLEVIEL 4L Cross-linking Technology, which was developed through researches

conducted by PharmaReserach Products that it is the viscoelastic HA gel with a physical
cross-linking reducing chemical cross-linking agent in high concentration HA.

※ Low BDDE reduce the risk related BDDE

※ Low Temperature Minimizes HA denaturation.
※ Low Swelling Improves procedure precision.
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※ Long Duration induce higher patient satisfaction
  2x Increased HA Concentration
 3x Greater Elasticity
 50% Lower Swelling

CLEVIEL Other
Contour HA filler
Content 50 mg/ml 20 – 25 mg/ml

Elasticity 4500 Pa > 1500 Pa

Swelling 1.2x 1.8 – 3x

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Feature 3. Effective Lifting Capability

Before deformation Start of deformation 1 min after deformation

R** filler

Cleviel

• CLEVIEL has a high elasticity and cohesiveness, which are the basic physical properties
of the filler, resulting in an effective lifting effect.
• CLEVIEL is composed of solid-formed gel that there is less shape deformation due to
external forces in everyday life.

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Feature 4. Gel Design with Uniform Consistency

• It is difficult to penetrate the enzyme or radical into the densely packed HA gel that keeps the gel structure
stable. The results of decomposition rate analysis study also support eh decomposition stability of CLEVIEL.
• CLEVIEL is composed of uniform particle size that it ensures constant injection force.

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 Doctor’s Guide

Dosage
Area Product (cc) Depth Precautions

* Entire Nose: 0.5~0.9cc / Nose Root: 0.5~0.7cc, Do not use into the dermis
Nose contour 0.5~0.9 supraperiosteal (Difficult to Mold)
* Do not recommend to use on nose tip where blood vessels are concentrated

Supracutaneous * Maximum 1cc at a point. When more needed, recommend to inject dispersedly
contour 1~1.5 / supraperiosteal * Excessive dosage can cause swelling and pain
Chin

prime 1~1.5 subcutaneous * Excessive dosage can cause movement within the tissue

*For volumizing purpose, 'Contour' on the periosteum and 'Prime' into the subcutaneous
Front fat layer but, recommend to use 'Prime' mainly ('Contour' is recommended only for
Cheek prime 0.5~1 subcutaneous
doctors with experience)

Subcutaneous/ *Recommended to use it deeper than blood vessels

Nasolabial submuscular * In the case of double layer technique, 0.5 cc of prime is recommended into the deep
Folds Prime 0.5~1
supraperiosteal layer, and balance treatment is recommended at the SQ level

Subcutaneous/
submuscular *When "high volume" is used excessively, Circulatory failure could be caused due to
Forehead prime 0.5~2.0 vascular compression
supraperiosteal

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 Removal Guide

Area Product Chemical Removal (Removal Guide) Precautions

Nose contour 2 Times 1,500 IU Hyaluronidase 1cc + Massage Physical removal is recommended for those who have
difficulty dissolving

Chin contour 2 Times 1,500 IU Hyaluronidase 2cc + Massage 1. Identify the overall shape and location

2. Inject hyaluronidase (Hand guide manual injection)

Front 3. Inject as much hyaluronidase as required
Cheeks prime 1,500 IU Hyaluronidase 2cc + Massage
(so that the filler can be detected to squeeze)

4. Puncture the most tight area with 18G needle

Nasolabial
Folds Prime 1,500 IU Hyaluronidase 1cc + Massage 5. Remove the filler by squeezing in the direction of several
angles.

Chin Prime 1,500 IU Hyaluronidase 2cc + Massage

Forehead prime 1,500 IU Hyaluronidase 2cc + Massage

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 Clinical Study

Comparative Evaluation of CLEVIEL Contour and Other Filler Products

Title for Nose Height and Angle Improvement Effect and Safety.

*Leaders Clinic, Cheongdam– Dr. Nark Kyoung Rho / *Yemiwon Dogok– Dr. Choon Shik Yoon
Institutions *Leaders Clinic, Apgujeong – Dr. Sung Jae Yoon

Period / Subject 24 weeks / 28 subjects (7 subjects per group)

Test Group: CLEVIEL Contour/ Cannula, needle

Product Used Control Group: J** V** / Cannula, needle

To evaluate the effect of improving nose height, angle improvment, shape change
Objective and retention compared to the control group

Observe each assigned product once after registering the subject,

Method 0.75ml±0.3ml applied once, observe for 24 weeks.

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Superimpose Picture Comparison: Immediate After Injection

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Superimpose Picture Comparison: 2 weeks After Injection

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Superimpose Picture Comparison: 12 weeks After Injection

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Superimpose Picture Comparison: 24 weeks After Injection

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Results

1. CLEVIEL Contour has significantly greater initial improvement than J** V** .
This is thought to be due to the high elasticity and high gel density of CLEVIEL.
2. CLEVIEL Contour is less likely to be deformed into an ‘Avatar nose shape’ than
J**V** because it doesn’t spread and the shape maintains better.
Beneficial for maintaining high and sharp shape.
3. CLEVIEL Contour has the advantage of returning to daily life
immediately after
treatment due to low swelling after injection.

4. Both products maintain good improvement for more than 6 months after injection.
But, after 3 months, the volume gradually decreases.

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 CONTOUR + with lido : Nose Contouring

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24 /20
 CONTOUR + with lido : Chin Contouring

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25 /20
 PRIME + with lido : Mid-face (Cheeks), Nasolabial Folds

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 THANK YOU
New Standard for Filler Selection, CLEVIEL

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27 /20