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  • Drug Targets

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    Bareera Nudrat
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    Drug targets are proteins in the body, such as G-protein coupled receptors, enzymes, ion channels, nuclear hormone receptors, and structural proteins, that are modified by drugs to produce either a desired therapeutic effect or an unwanted adverse effect. Common drug targets include G-protein coupled receptors, which are targeted by 50% of drugs, as well as enzymes like kinases, proteases, and esterases. Ion channels that are frequently targeted include ligand-gated ion channels, voltage-gated ion channels, and the nicotinic receptor.

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    Drug targets are proteins in the body, such as G-protein coupled receptors, enzymes, ion channels, nuclear hormone receptors, and structural proteins, that are modified by drugs to produce either a desired therapeutic effect or an unwanted adverse effect. Common drug targets include G-protein coupled receptors, which are targeted by 50% of drugs, as well as enzymes like kinases, proteases, and esterases. Ion channels that are frequently targeted include ligand-gated ion channels, voltage-gated ion channels, and the nicotinic receptor.

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    7 views6 pages

    Drug Targets

    Uploaded by

    Bareera Nudrat
    Drug targets are proteins in the body, such as G-protein coupled receptors, enzymes, ion channels, nuclear hormone receptors, and structural proteins, that are modified by drugs to produce either a desired therapeutic effect or an unwanted adverse effect. Common drug targets include G-protein coupled receptors, which are targeted by 50% of drugs, as well as enzymes like kinases, proteases, and esterases. Ion channels that are frequently targeted include ligand-gated ion channels, voltage-gated ion channels, and the nicotinic receptor.

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    © All Rights Reserved
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    of 6

    Drug targets

    Frequently used in pharmaceutical research


    Describe the native protein in the body
    whose activity is modified by a drug
    Resulting in a specific effect
    May be a desirable therapeutic effect 
    or an unwanted adverse effect
    Often referred to as a drug target
    • Most common drug targets include:
    • Proteins
    – G-protein Couple Receptor (target of
    50% of drugs)
    .α
    .β
    .M
    Enzymes:
    Drugs target various enzyme
    Blocking their activity
    ACE-inhibitor
    Ach-esterase Inhibitor
    Protein Kinases
    Proteases
    Esterases
    Phosphatases
    Ion channels
    • Ligand-gated ion channels
    • Voltage-gated ion channels
    Nicotinic Receptor
    Benzodiazepine Receptor
    Local Anesthetic
    Antiepileptic
    Ca-channel Blocker
    Nuclear hormone receptors
    – Structural proteins such as tubulin
    Anticancer drug
    – Membrane transport proteins
    Carrier Protein
    • Nucleic acids

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