Japanese

Encephalitis
Group Members: Saif ul eman, Alavia Batool,
Mudassar Iqbal
TABLE OF CONTENTS

01 Introduction
Historical Background and JEV
02 Pathogenesis
Transmission and Disease

03 Treatment
Vaccines
 What is Japanese
encephalitis?
Japanese encephalitis is the most important form of viral
encephalitis in Asia.
It is a mosquito-borne flavivirus belongs to the same
genus as dengue, yellow fever and West Nile viruses.
Historical Background
• Epidemics of encephalitis were described in Japan from the
1870s onwards
• Major epidemics were reported about every 10 years
• 50 000 cases and 15 000 deaths annually
• About one third of patients die
• Most of China, Southeast Asia, and the Indian subcontinent
are affected by the virus
Japanese Encephalitis Virus
• A small (50 nm) lipoprotein envelope
• Surrounds a nucleocapsid comprising of core protein
• 11 kb single stranded RNA
• At least five genotypes of Japanese encephalitis virus occur in
Asia
• Determinants of virulence in animal models of flavivirus
encephalitis has focused on the E protein
Map showing approximate global distribution of major neurotropic flaviviruses