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GAS EXCHANGE + GAS TRANSPORT

DIFFUSION - movement of molecules through a


semipermeable barrier from an area of higher
concentration to area of lower concentration
ATHMOSPHERIC AIR
756mmHg
N2 02 C02 H20
Dalton’s Law - the total
597 159 0.3 3.7 pressure exerted by a mixture
mmHg mmHg mmHg mmHg of gases is the sum of all partial
pressures of gases

Partial Pressure - the pressure of a single type of gas in a mixture of gases


Gas Solubility in Liquids

Henry’s law - the concentration of gas in a liquid is directly proportional to the


solubility and partial pressure of that gas.

The greater the partial pressure of the gas, the greater the number of gas
molecules that will dissolve in the liquid.
N2 02 C02 H20
ATHMOSPHERIC AIR
597 159 0.3 3.7
(inhaled air)
mmHg mmHg mmHg mmHg

569 104 40 47 ALVEOLAR


mmHg mmHg mmHg mmHg AIR
Ventilation vs. Perfusion
Ventilation vs. Perfusion
2 SITES OF GAS EXCHANGE

LUNGS (EXTERNAL) TISSUES (INTERNAL)


GAS TRANSPORT
IN THE BLOOD
O2 C02

• Dissolved in the blood* • Dissolved in the blood*


• Binds to Hemoglobin*
• Binds to Hemoglobin** • Bicarbonate**
Carbaminohemoglobin =
Maroon color of blood
GAS TRANSPORT
IN THE BLOOD
O2 C02

• Dissolved in the blood* • Dissolved in the blood*


• Binds to Hemoglobin*
• Binds to Hemoglobin** • Bicarbonate**
Factors affecting gas exchange

1. Magnitude of Partial Pressure Gradient (HENRY’S LAW)


Factors affecting gas exchange

2. Thickness of RESPIRATORY MEMBRANE

normal Pneumonia Heart Failure


Factors affecting gas exchange

3. Alveolar Space

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