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CS474 - BIOINFORMATICS
Introduction
Dr. Raja Hashim Ali
27 Aug 2019
Faculty of Computer Science & Engineering
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• Include CS474 in the subject of your e-mail.
• Use TA as much as possible.
Textbook
Course content
• Introduction to Bioinformatics (2 lectures) • Phylogenetic inference (6 lectures)
• Motivation • Background & Applications
• Definition • Data
• Representation
• Applications
• Methods & Algorithms
• Types
• Genome Assembly Problem (5 lectures)
• Relevance to you
• Background
• Data of Bioinformatics (4 lectures) • Data
• Genes, chromosomes, cells, & organisms • Types
• Graph-based solution
• Taxonomy & Nomenclature
• Microarray Expression Analysis (4 lectures)
• DNA, RNA & Proteins
• Background
• Similarity & differences with text
• Data
• Central dogma • Types
• Sequence Analysis (18 lectures) • Algorithms
• Introduction • Case studies (3 lectures)
– ALS Disease
• Pairwise & multiple sequence alignment
– Phylogeny of FERM domain
• Local & global alignment
– Development of Divvying for filtering MSAs
• Dynamic programming algorithms
• Databases in Bioinformatics (2 lectures)
• Heuristic based algorithms – BLAST
• Conclusion (1 lecture)
• Methods for multiple sequence alignments
• Filtering uncertainty in multiple sequence alignments
• Motif-finding problem & algorithms
QUESTIONS?