PREPARATION 31

HYDROCORTISONE SUSPENSION

 SUSPENSION
Are liquid preparations that
consist of solid particles
dispersed throughout a liquid
phase in which the particles are
not soluble.

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Category
 Suspension

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Examples
 Antacids – alumina, magnesia, simethicone,
magaldrate
 Anthelmintics – Pyrantel pamoate,
Thaibendazole
 Antibacterials – Ciprofloxacin, Erythromycin
estolate
 Antiflatulent - Simethicone
 Antifungals – Nystatin
 Antiprotozoal - Atovaquone
By: Nelson T. Tubon
 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Synonyms
 Hydrocortison Cypionate
 Cortisol suspension

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Description of Final Product
 It is a pink, viscous
suspension. The dispersed
particles settle minimally on
standing and easily redispersed
with shaking

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Use/s
 Temporary relief of minor skin irritation
 Itching
 Rashes
 Insect bites

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Formulation
Ingredients OA CA

Hydrocortisone 1% 150 mg
Menthol (aliquot) 1/8% 18.75 (37.5 mg)
Calamine (5%) 3g 0.75 g
70% alcohol 10% 2.14 mL
Cetaphil (67%) 40 mL 10 mL
Distilled water, q.s. ad 60 mL 15 mL

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Computations

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Computations
 Hydrocortisone
1% (0.01) x 15 mL = 0.15g or 150 mg

 Menthol
0.125% x 15 mL = 0.01875g or 18.75 mg x 2 =
37.5 mg

** Dissolve 37.5 mg (menthol) in 1 mL of IPA and take

half (0.5mL) of this
By: Nelson T. Tubon
 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Computations
Calamine
3g for (60 mL) 0.75g for (15mL)

*** 0.75g:15mL::x:100mL = 5g/100mL or 5%

70% alcohol v/v (need 10%)

0.1 x 15 mL = 1.5 mL

*** 70mL:100mL::1.5mL:x x= 2.14 mL of 70% alcohol

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Computations
Cetaphil
40 mL for 60 mL 10 mL for 15 mL

*** 10mL:15mL::x:100mL = 66.7 mL/100mL or 67%

 Distilled water, q.s ad. 15 mL

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Procedure
 Weigh specific amount of menthol,
hydrocortisone, and calamine.
 Dissolve the menthol in 1 mL of IPA
in graduated cylinder
 Place the hydrocortisone in a mortar,
and add calamine geometrically
By: Nelson T. Tubon
 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Procedure
Take 0.50 mL of the menthol-
IPA solution and add 1.64 ml
IPA and add to the powders in
mortar and triturate = to form
smooth & uniform paste

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Procedure
 Add 2.5 mL of water to the solution
before adding 10 mL of Cetaphil
with trituration
Note: to dilute the alcohol because Cetaphil
has components that are soluble in IPA

*** too high IPA concentration will break down

the emulsion structure of Cetaphil
By: Nelson T. Tubon
 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Procedure
Note: Do not over triturate the preparation
because Cetaphil contains surfactant that
facilitates the introduction of air bubbles
called “SUDS”
 Transfer to a 15 mL bottle
 Use little more water to rinse mortar and add
to the container
 Then, q.s with water to 15 mL.

By: Nelson T. Tubon

 PREPARATION 31
HYDROCORTISONE SUSPENSION
 Label
 Red Label

 Container
 15 mL amber bottle

By: Nelson T. Tubon