PREPARATION 28

MIXTURES
 Mixtures
 particle size > 0.5 µm
 aqueous liquid preparation which contains
suspended (suspensoid), insoluble solid
substances
 The insoluble substance maybe held in
suspension by the use of suitable
suspending or thickening agent since the
insoluble substance does not make the
mixture very viscous
By: Nelson T. Tubon
 PREPARATION 28
MIXTURES
 Insoluble Substances
 must be in very finely divided state
and it must be uniformly distributed
throughout the preparation
 this is accomplished by the use of
colloid mill, special methods of
precipitation and suspending agent

By: Nelson T. Tubon

 PREPARATION 28
MIXTURES
 Reasons for having the Insoluble substance in
a finer state of subdivision
 The more active they become as adsorbent
and protectives when in contact with the
inflamed areas
 Suspended more readily and settle out much
slowly than large particles, thus enabling the
patient to obtain uniform doses of suspended
particles
 To increase palatability of the preparation with
the use of colloidal suspending agent
By: Nelson T. Tubon
 PREPARATION 28
CHALK MIXTURE
 Category
 Medicated Mixture

By: Nelson T. Tubon

 PREPARATION 28
CHALK MIXTURES
 Synonyms
 Mixture de Creta
 Mistura Cratae

By: Nelson T. Tubon

 PREPARATION 28
CHALK MIXTURE
 Description of Final Product
 A whitish mixture containing
suspended, insoluble solid
substance

By: Nelson T. Tubon

 PREPARATION 28
CHALK MIXTURE
 Use/s
 antacid
antidiarrheal agent

By: Nelson T. Tubon

 PREPARATION 28
CHALK MIXTURE
 Formulation

Ingredients OA CA

Precipitated Chalk 60 g

Glycerin 100 mL

Cinnamon water 400 mL

Purified water, qs ad 1000 mL 15 mL

By: Nelson T. Tubon

 PREPARATION 28
CHALK MIXTURE
 Computations

By: Nelson T. Tubon

 PREPARATION 28
CHALK MIXTURE
 Procedure
Triturate the calcium carbonate
with 5 mL water
 Add glycerin and levigate
 Add cinnamon water and
triturate
 Transfer mixture in a graduated
cylinder
By: Nelson T. Tubon
 PREPARATION 28
CHALK MIXTURE
 Procedure
 Wash mortar with purified water,
add washings to the cylinder
 Add enough water to complete the
volume

By: Nelson T. Tubon

 PREPARATION 28
CHALK MIXTURE
 Label
 ?????

 Container
 15 mL flint bottle

By: Nelson T. Tubon

 PREPARATION 28
CHALK MIXTURE
 Remarks
 Method  simple hydration
 Glycerin  viscosity agent

By: Nelson T. Tubon