#6 GLYCERIN SUPPOSITORIES

Tablet lubricant Magnesium stearate

Suppository - solid dosage form intended

for insertion into the body orifices where
they melt, soften, dissolvem and exert
localizied or systemic effect.

Disintegrating agent - startch

5 TYPES OF SUPPOSITORIES

4. otic (aural) pencil-shaped

1. rectal - cylindrical or bullet shape

5. nasal (burginarium) pencil-shaped

- 32 mm (1 inch)

CRITERIA FOR SUPPOSITORIES

- 2g adult; 1g children

1. melts at body temperature

Use: glyercin laxative effect

Sodium stearate (Soap); solidifying
agent

Cathartic acts directly on colonic

mucosa
to
produce
normal
peristalsis. Not appreciably affects
the motility of small intestine
Relieve
pruritus ani pain
associated w/ hemorrhoids
constipation

2. urethral
(bougies
slender, pencil shaped.

Use: anti-fungal
Anti-infective
Contraceptive (w/ spermicide)

or

inserts)

2. firm at room temperature

3. yields at clear melt
4. inert and compatible with other agent
5. wetting and emulsifying
6. acid value (<0-2)
7. saponification value (200-245) if it forms
ester
8. non- irritating

Male: 4g; 140 mm long, 3-6 mm diameter

9. iodine value (<7) determines

unsaturation of double bonds (C=C)

Female: 2g; 60-70 mm long

TYPES OF SUPPOSITORY BASES

Uses:

1. tend to melt -

o
o
o
o

dilatation of uterus
Anti-infective agent
Erectile dysfunction
Tx of local infection

3. vaginal (pessaries) - globular, oviform,

cone-shaped; 5 grams.
Caused by: Trichomonas vaginalis, Candida
(Monilia) albicans, Haemophilus vaginalis

Estrogenic
substances
(dienestrol) used to restore the
vaginal mucosa to its normal state.

Vaginal tablets
(vaginal inserts) easier to manufacture, more stable, and less
messy.

Anti-infective
w/ homonal substances

the

cocoa butter (theobroma oil)

polymorphic
- very good suppository base for
rectal, seldom used in vagina and
urethral
- tendency to lower melting point
- inability to absorb aqueous solution
witepool C12 C18 (no polymorphism)
wecobee only suppository base that
came from coconut oil

2. tend to dissolve polyethylene gylcol

(PEG)
- PEG liquid (300, 400, 600)
- PEG semi-solid
- PEG solid- wax ( > 1000)- clear
colorless liquid

METHODS OF PREPARATION
1. hand rolling mixing and rolling in a
pile tile.
2. compression appearnce

more elegant in

- very simple avoid sedimentation

- not for large manufacturing

- mix -> supp. Compression device ->

apply pressure -> cool
3. fusion method
-

melting of all ingredients

pour directly to mold
freeze
wrap in Aluminum foil