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Pharmaceutical Dosage Forms (Phar 3) Laboratory Manual

Name: Pjchw/, Christian Oq,µJo Sec:ll·P/.J Group no.:.£ Date: _ _ __

SN · Sumame, Fhst name 49

PREPARATION #10: SULFUR OINTMENT

"{?\ .
\.!.../ Past I.ab Questions:
l. Method of preparation? Mechohicol /l'lt0rpb/"afion

2. Official or none 9fficial preparation~ _....Joi..!:.r:.i:.r:1L.:.

·cc!.l.iru"'"----

3. Give the stepwise procedure of filling ointment tubes.with prepared

ointment using a small scale filling machine. ·
a . When tlie procl.uc; is ~Octy, 0 oump pump is usea +l) fransPe,- it t6 fhP s;oroge Mr,1r'
Tfle s;oroge VPS'se, usually /JQS' h•o+in9 & rnovin9 Pa~ilify («Jnee1SJ.
b. rhe Sf0ro9Q vesseL is, •hen +o~en ,o I-he PIiiing mQc>,/ne ohct +he mo+eria1 is heQteol +o
maJ<e +he tran,;Per ·easy. Then _a 1'1Qfprinq pump iS u!!.rcl +o ffO'}S'~er fhe prodqr:-1 fO ,he
•hopper OP +he Pilling mac-hint.
c. trip!<' roller mill ir- urrcl l-0 remove ' e.x+ro w.01-@r F;,-orr, "i?~ rino1 proc/c.1cl bero~ F".il/in~
i+ jnt.O +h _P fUbPS. /f 01ro pc,r,S,er hPIPS hon,091.'1i~in9 rh~ proo/ucf .
d - rhr ,ubes on 1,0ocHcl in/o +h• Pi11iri9 m<>chlnes . Th• piS,or, 01> +he f'l1iin9 fhochine Uf.
iinc1er renct, Ovf +he ca1<-ulo_1rc1 qmoulJt . oP •he •in+mer,1 fOf<~ 1, qO~S' /hro..,9S, o non/e in-
tO H,f tube duP ,o ruc1rin9 hl~chOnism.
e - .1>Ffe• p111in9, +h1 +UbE passes .fh~ou 9 h .i,e pre,~in9 s-~ofio0 ,Ni,.,.oih9 ~Otio1), & ui<;1;ng

~/OtiOnS respPdiVety.
P. ,n +h~ ,net ,+1>en ._ on: r•o1ir,9 ·moci-,ineS' process · Ond +rimmil)g QP;e;- oJhich " ji,ey ore ej-
ea~d out pn,m fhP nl/in9 mochin.e..
_ c,P· ccieor,-in-~toce) S'(!Stems a.u1omo+ico//9 Nosh 011 u,ri10iner5 ur;ec1 in +he Pl"Ocerres.
9

4. Enumerate at least three (3) other official or non-official medicated

ointments in the latest edition of USP/NF. Photocopy and 'attach It to
these page.
•o. Lidocoine ointment uSP

, indico+ec1 ror procl.Uction or onesthesio oF occessibl( JrWCo<:JS membranes or +he

orophor<:JhX. tt ir o,ro <:JSePu1 1n on an •iN-/.,/Yic wbric-onf f'Or ihtUi,otion tor the
Hmporor~ 1"6/i Qf OP pain

b- oeso><lme,asone o/n+ment uSP

, ... ~ed ro, +he retie; oP inl'tamma ,o'V PNritic mor,,,e•not-lons· op U>Nic.oStP,nid -rrsp()flSi~e
aerMbtOS!'S
c- c:ien+omicin SUll'ate USP
) primary r~ln iMeoionS : impetigo eon+ogioS"o, · _ruperPiciot POJ1ic.~1i1is I ecthyma, He.
t;'•C.Or,dOl'iJ '?~in /Ofed1DnS: /nFrctlDUS ~c2 ·~ 1nQlo/cl cJer/h<,tit-is, P'J'Nu{or orn~, Pfc,
7

University of Santo Tumas Faculty of Pharmacy

 Lidocaine Ointment USP
Indications and Usage: Desoximetasone Ointment, 0.25% is indicated for the relief of
inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Reference: U.S. National Library of Medicine. (2020). Lidocaine Ointment. Retrieved from
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=d1509740-f9f1-44e3-8fde-
51d8683fcd87&type=display
 Gentamicin Sulfate Ointment USP
Indications and Usage:

• Primary skin infections: Impetigo contagiosa, superficial folliculitis, ecthyma,

furunculosis, sycosis barbae, and pyoderma gangrenosum.
• Secondary skin infections: Infectious eczematoid dermatitis, pustular acne, pustular
psoriasis, infected seborrheic dermatitis, infected contact dermatitis (including poison ivy),
infected excoriations, and bacterial superinfections of fungal or viral infections.

Reference: U.S. National Library of Medicine. (2018). Gentamicin Sulfate Ointment. Retrieved
from https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a9486ae1-350b-41c5-
ae0c-a4d692bb2dfd&type=display
 Desoximetasone Ointment USP
Indications and Usage: Lidocaine Ointment 5% is indicated for production of anesthesia of
accessible mucous membranes of the oropharynx. It is also useful as an anesthetic lubricant for
intubation and for the temporary relief of pain associated with minor burns, including sunburn,
abrasions of the skin, and insect bites.

Reference: U.S. National Library of Medicine. (2019). Desoximetasone Ointment. Retrieved from
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e9dd2405-f89f-4f97-917f-
6b8a3d2a9840&type=display
 Pharmaceutical Dosage Forms (Phar 3) Laboratory Manual

73 Name: P/GbQl/ Cbcisti90 PgJ110

SN Sumaine, First name
Sec:11-PH Group no.:_2_ Date: _____ - 53

PREPARATION #11: CINNAMON WATER

(:;\ . .

'..!.I Post Lab Questions:

1. Whai is the method used in preparing Cinnamon Wator?
Direcf Me+hocl was usec1 in prr:?porit>g cinnamon wa1,er.

2. · Whal is the advantage and disadvantage of the method used in

preparing Cinnamon Water~
oirec+ 'i:OW+ion Mf:fhocl
Rd\/On~oge :
- rove +ime and equipment
o;saovan1a9f' :
- oo no1 agitaJe when drawing or.· aromafic wofef' ic- .fhe ex ~SS

voLCl.liLe oil ir, a11owed fo remo10.

3. How should the preparation be stored and why?

The preparo+ior, ,houtd be ,fored in o +ight arid light re5istont
lonlainer fo prevent the preparatio0 t:rom tight and excessive

vo1a~lli-z otion.

4. Give the sources and alcohol content of the foliowing distilled beverages:
A. Rhum - ,ourcP : F•r-mentod rugarcane or m.o,asses
alcohol content : 'o<D - 50 "/• 0/<.oh.oi bLJ vc<.urne ( tlf>V J

B. Wine - ',OUrCe: '>+onc/ord «uit (9rape,,•+c) or honey olcohOl

- aooho, wn+ent ·. " 14 •1° fl \I

C. Whisky - <;()urce: di's+illed ~ermen +eel groin

- altc,h-0/ u,ntent; '/0 'lo - 1)0 .,. 1ie,v

D. Beer - l"()urce : Cef'<a/5

- o/c..oh01 wntenr: •1._ ((' bt" ll BV

E. Brandy - ~ource : aisf,11 ed win c

- alc.oh-01 <-or,fenf: ~o•/• - (JJO'/• Qe,V

University of Santo Tomas Faculty of Pharmacy

 Pharmaceutical Dosage Forms (Phar 3) Laboratory Manual

22.. Nome:
SN
Picha4, Chrirttiao Pau10 D.
Surname, First name
Sec:11-PHGroup no.:..2..... Date: _ _ _ __ - 57

PREPARATION #12: CONCENTRATED PEPPERMINT WATER

Ci) Post Lab QuesHon:s:

1. What is the rr.ethod of preparing Peppermint Water?

The rnPthocl u sec:1 was alfUrJol:~ >01.,u+ion me+hOd .

2. Why is this method/process frequently employed among the methods of

preparing aromatic waters?
AHema tE> SoLUtion rn~+hod has 1oeen deuetoped &. Pffque0+1':J used

to over<..orne diPPi c.u/fies '.Uch a s cLOriPication one/ Cl/"n.ount OP

tirnf wnsum ed in the fimp,e f'Dwfion me11-iod, 11 ,s lons-idered

the eosies-1 &. .-asfeS'f me+hod oP prcporin3 Qromotic wa+ers fOo .

3.What is ihe importance of ethyl alcohol and talc in the preparation?

f+h<J/ aJLOho/ i,vqs used to cfisso1ve pepperrnirit OiL .

ra1c wos used as a di5persin9 a9ent, ancJ Pill-er aid

to make +h e p re paration Clearer .

University of Santo Tomas Faculty of Pharmacy

 Pharmaceutical Dosage Forms (Phar 3) Laboratory Manual

23 Name: Pichau, Chtisflao Fg,utp

SN Surname, First nome
Sec:1.J.,f!-/Group no.:.J._ Date: _ _ _ __ - 61
PREPARATION #13: CALCIUM HYDROXIDE TOPICAL SOI.UTION

(jJ Post Lab Questions:

1. What is the method of preparing Calcium hydroxide solution~

The mefhOd op preparation was simpte me+hod-

2. What is the suitable container for the preparation and the appropriate
storage condition?
The ,-otu+ion Shoutcl be s+orecl a wet/ -Fitted, +ightiy s1-oppered
w()fainers to defer fhe absorption ot= w, &. rhould be

Kep/- in a U)OJ pLDce to main fain on adequafe LOncen+ra-

fiOn oP diS5oJved sowfe.

3. How is it categorized and as such where is it generally employed?

The SOUJf iOn is ca1-eqori2ed as on as1-rin9en1: . 1+ is qenero11y
emptoljed ih lOmbination wil-h other ih9rrclien+S in c1erma -
to10 gic r;ow+1ons &. totlDnS t-o 1:>e opptiecl.

University of Santo Tomas Faculty of Pharmacy

 -
Pharmaceutical Dosage Forms (Phar 3) Laboratory Manual

n.._Name: Prchq,,, Chr-iSlian pqµ10 Sec:1J..:£t1Groupno.:__!i_Date:.,_____

65
11
SN Sumome, First name

PREPARATION #14: STRONG IODINE SOLUTION

fri'I .
\.!.J Post Lab Queslfons:
1. What is the method used in preparing Strong Iodine Solution?
Thi? mefhoo/ oP preporcuion usec1 was SifYJple r;oLu+ion.

2. In weighing the iodina crystals, what type of spatula should be used and
why?
/11 weighing iodine crystoLS, o porce/oin spatula S-hould be

used insfeoct OF o <;tain1ess s-potuta as if reac+s wit:r,

rnetaL-

3. Why is there a need to add Potassium iodide in the preparation?

Pornssiurn JOdide was useol oi:- a S'0lUbilizin9 agent in +he

preparation.

University of Santo Tomas Faculty of Pharmacy

 -
Pharmaceutical Dosage Forms (Phar 3) Laboratory Manual
r---- -

1..1. NamE: P1chau christ!Oo Paulr, o. Sec:11.:.!:.HGroup no.:...Q_ Date:----

SN Surname, R,st name 69
PREPARATION #15: MAGNESIUM CITRATE ORAL SOLUTION

(:f) Post Lab Questions:

1. What is the method used in prei:,aring Magnesium Citrate Oral Solution?
Write the eq•Jations involved in the preparotion.
rhe method oP preparo,ion used was chemica1 reaction.
equati o ns involved:
{MgCO?>)L/ . Mg (01-/)i. 51-120+ 51-13Cc,,l-/501-, 5M91-1Ct,i-/507t-'/CD? It ii 1-1'.10
?,KHC03 + J..1?,(i,,J-1501 -> K?,Ci,,J-1.501+ :3 W2 /+ 31-/20

2. Why is Magnesium Citrate Oral solution always been troublesome and

what is the cause of the problem?
Magnesium citraie Oral sotufiOrJ has a +enden"'I +o deposit a cr1,1sta//ine
s01id upon s+onding. This is du~ fo I-he Pormafion 0 , som e aimost
inSOt.ubl</- nort11q1 Mg ci+ro1e. The ca,use oP +he probiern hos Largriy
attributed +o 1-he indl?f:inife wmposition o, 1-he oc-cicia/ 1v1g c.o 3 w/c
b~ dH'i nition Is a basic/normo1 h4o/ra+ed 1v1 9 co, .
3. What should be done during manufacture of the solution to retain its
stability?
ro retain ifs s1abi1ifc_}1 molds or an4 molcf spores mus+ be kilted
during the marwPocw~ op +he Sowtion. rhiS is dorir by heoiing
+he 1iquid to boiling &. rinsing +he rinot c.on+ O,·,,,
, , er iv,,,,
·, ,. boitin
9
wOfQr to s-1erili1~ +he 1:>offle fh e rowfion . This p re ven1s
Lon+amina+lon the reby Keeping th-e p re paration s+ablf' .
4. What is the method of storing Magnesium citrate?
>Aagnesiurn citro1e sow11on is stored in o wlc/ pt act, pre,erab1y if)
a rei;n9era1or. 'The bofflr "houloi bt: 1<~p1 on ifs Sid e so fht: LOrk
or rubbE'r liner or: t-h~ cap is Kepf mo is1 or su;o11 en . This is irn -
porl-Onf t-0 maintain th e airtigh+ '.eat be1wee0 t-h e cap & ~he t:,Ot-
tl e.

University of Santo Tomas Faculty of Pharmacy