Topic

Role of thiamine in neuroprotection

in term neonates with severe
perinatal asphyxia .

BY- Dr Abiya Nabi , Junior Resident , Pediatric Kgmu under

guidance of PROF DR MALA KUMAR (MD)

Co-Guides – Prof Dr S N Singh(MD), Prof Dr S Tripathi (MD),

Prof Dr H. Kaur (MD, DM)
 OBJECTIVE

1) To evaluate Neurological status of full term neonates born after severe perinatal
asphyxia and to compare it among neonates given standard care and standard
care along with thiamine .

2) To compare in neonates given standard care vs standard care along with thiamine
a) Time to start Feed
b) Time to start full entered feed .
c) Time to feed with spoon .
d) Time to feed on breast
e) Seizures
f) Duration and no of Antiseptic drugs taken
g) Total hospitality stay
h) Neuroimaging and EEG where possible
 Severe Asphyxia

Neonates given standard care - Feeding Detail

- Seizures
- AED number and duration

Neonates given standard care

along with thiamine

Outcome

Death
Discharge LAMA
- Neurological Examination
at discharge
Exclusion Criteria
1) Babies dying with 7 days of being born

2) Congenital malformation .