HYDROLIZED

COLLAGEN
uses, dosage, and side effect

dr. Adam Nur Rahman

 What is collagen?

 Collagen is one of the primary proteins in your

body. Comprising amino acid chains, it’s an
important part of structural components and
connective tissues like skin, tendons, muscles,
ligaments, and blood vessels, as well as parts of
your eyes and teeth
 Collagen also helps with blood clotting, wound
healing, and protecting the nervous system
 Types of collagen

Collagen is an abundant protein, with 28 types having been identified to

date.

Types I, II, III, IV, and V are the most common in the human body

It’s believed that the various types of collagen serve unique purposes. For
example, older research has identified that types I and III present
together in the organs and skin, while type II is typically found in joints and
cartilage
Types of collagen
 Lose of collagen

As your body ages, it loses collagen. By age 40, you can

lose up to 1% of your body’s collagen each year

Other factors like diet, regularly smoking, consuming

alcohol, and sun exposure also affect collagen loss

Loss of this protein is one reason why your skin loses

structure and begins to wrinkle as you age. It may also
affect the strength of your bones, joints, and more.
Collagen supplements

Collagen
5000 gram
 collagen supplements

Skin structure
preservation

Hair and nail Wound

health healing

Muscle mass Anti-aging

improvement support

Bone loss Improving

prevention Osteoarthritis
Forms used in supplements

Gelatin

• This is cooked collagen, usually derived from animal sources.

Undenatured collagen

• This is raw collagen derived from chicken cartilage.

Hydrolyzed collagen (collagen hydrolysate)

• This type is derived from bovine (cattle), marine (seafood), poultry

(often chicken or eggshells), pigs, and other animal sources, and it’s
broken down into smaller and easier-to-absorb peptide particles.
Collagen Structure
Hydrolyzed collagen

Hydrolyzed collagen is one of the most common

forms used in supplements, as it’s absorbed more
readily than other types. It’s often sold in
capsule or powder form, the latter of which you
can add to hot and cold beverages, soups, and
even baked goods or other foods
 Proper dosage

 Currently, health authorities haven’t provided

any official guidelines regarding how much
collagen to take per day.
 Thus, the amount of collagen you should take
depends on which form you’re taking and why
you’re taking it.
 Clinical studies

 A 2019 review of clinical studies found that taking 2.5–

15 grams of hydrolyzed collagen peptides each day may
be safe and effective.
 A smaller daily dose of 2.5 grams could benefit joint
pain, skin health, and hydration.
 Increasing this dose to 5 grams per day has shown the
potential to improve bone density.
 Lastly, larger daily doses of 15 grams of these peptides
have mostly been used to improve muscle mass and body
composition.
How long does it take to see results?

 Collagen turnover is a slow process. As such, no

matter your goal for using collagen, it will take at
least 8 weeks to experience noticeable results.
 Most studies use a minimum of 8 weeks to assess
collagen’s effects on skin health and joint pain
relief, but other studies use longer periods, such
as 12 months, for bone health.
 Thus, you should be patient and not expect
results for a while.
 Can you take too much?

 Collagen is generally considered to be a safe and

nontoxic daily supplement for healthy
individuals, and most people won’t experience
adverse side effects.
 Still, some have reported symptoms, such as an
unpleasant taste, feeling overly full, or other
stomach complaints.
 Conclusion

Collagen is a protein in
your body that makes up
many tissues and organs.
Supplementing with the
A 2.5–15-gram daily dose of
protein may help preserve
collagen appears to be safe and
skin health, muscle mass,
effective. The amount you
bones, and joints.
should take depends on the
particular supplement and why
you’re taking it.
 refference

 Deshmukh SN, Dive AM, Moharil R, Munde P. Enigmatic insight into collagen. J Oral
Maxillofac Pathol. 2016 May-Aug;20(2):276-83. doi: 10.4103/0973-029X.185932. PMID:
27601823; PMCID: PMC4989561.
 Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2011 Jan
1;3(1):a004978. doi: 10.1101/cshperspect.a004978. PMID: 21421911; PMCID:
PMC3003457.
 León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI,
Aguirre-Álvarez G. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019 Nov
7;24(22):4031. doi: 10.3390/molecules24224031. PMID: 31703345; PMCID: PMC6891674.
 Lupu MA, Gradisteanu Pircalabioru G, Chifiriuc MC, Albulescu R, Tanase C. Beneficial
effects of food supplements based on hydrolyzed collagen for skin care (Review). Exp
Ther Med. 2020 Jul;20(1):12-17. doi: 10.3892/etm.2019.8342. Epub 2019 Dec 17. PMID:
32508986; PMCID: PMC7271718.
 Barati M, Jabbari M, Navekar R, Farahmand F, Zeinalian R, Salehi-Sahlabadi A,
Abbaszadeh N, Mokari-Yamchi A, Davoodi SH. Collagen supplementation for skin health: A
mechanistic systematic review. J Cosmet Dermatol. 2020 Nov;19(11):2820-2829. doi:
10.1111/jocd.13435. Epub 2020 May 21. PMID: 32436266.
 refference

 Choi FD, Sung CT, Juhasz ML, Mesinkovsk NA. Oral Collagen Supplementation: A
Systematic Review of Dermatological Applications. J Drugs Dermatol. 2019 Jan 1;18(1):9-
16. PMID: 30681787.
 Czajka A, Kania EM, Genovese L, Corbo A, Merone G, Luci C, Sibilla S. Daily oral
supplementation with collagen peptides combined with vitamins and other bioactive
compounds improves skin elasticity and has a beneficial effect on joint and general
wellbeing. Nutr Res. 2018 Sep;57:97-108. doi: 10.1016/j.nutres.2018.06.001. Epub 2018
Jun 9. PMID: 30122200.
 Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral Intake of Low-Molecular-Weight Collagen
Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized,
Double-Blind, Placebo-Controlled Study. Nutrients. 2018 Jun 26;10(7):826. doi:
10.3390/nu10070826. PMID: 29949889; PMCID: PMC6073484.
 Van Vijven JP, Luijsterburg PA, Verhagen AP, van Osch GJ, Kloppenburg M, Bierma-
Zeinstra SM. Symptomatic and chondroprotective treatment with collagen derivatives in
osteoarthritis: a systematic review. Osteoarthritis Cartilage. 2012 Aug;20(8):809-21. doi:
10.1016/j.joca.2012.04.008. Epub 2012 Apr 17. PMID: 22521757.
 refference

 Wu M, Cronin K, Crane JS. Biochemistry, Collagen Synthesis. [Updated 2022 Sep 12]. In:
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available
from:https://www.ncbi.nlm.nih.gov/books/NBK507709/
 Bolke L, Schlippe G, Gerß J, Voss W. A Collagen Supplement Improves Skin Hydration,
Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind
Study. Nutrients. 2019 Oct 17;11(10):2494. doi: 10.3390/nu11102494. PMID: 31627309;
PMCID: PMC6835901.
 Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific
bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.
Skin Pharmacol Physiol. 2014;27(3):113-9. doi: 10.1159/000355523. Epub 2013 Dec 24.
PMID: 24401291.
 Schauss AG, Stenehjem J, Park J, Endres JR, Clewell A. Effect of the novel low molecular
weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving
osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. J
Agric Food Chem. 2012 Apr 25;60(16):4096-101. doi: 10.1021/jf205295u. Epub 2012 Apr
16. PMID: 22486722.
discussion

Apa ada
pertanyaan?