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Principles of Oxygen Therapy, NIPPV,

and IPPV for COVID-19 Patient


Ventilation protocol
Non-invasive positive pressure ventilation (NIPPV)- including High-flow
nasal oxygen therapy)
• Not intubated
• Spontaneously breathing pt.
• Tight-fitting mask
• Ventilator supports each breath
• Need –ve pressure rooms
• IPPV
• Intubation/tracheostomy
• Partial support:
SIMV(Synchronized intermittent mandatory ventilation)
- Pressure support
-ASV (Adaptive Support Ventilation)

Full support:
CMV Continuous mandatory ventilation : AC/VC
AC vs SIMV
Evidence-based practices

•Start supplemental oxygen


•if the peripheral oxygen saturation (Spo2)is < 92%

•In adults with COVID-19 and acute hypoxemic respiratory failure on


oxygen, SpO2 is maintained no higher than 96%. Strong
Evidence-based practices, cont’d

•In adults with COVID-19 receiving NIPPV or HFNC, close monitoring for worsening respiratory
status, and early intubation in a controlled setting if worsening occurs. Best practice statement

•In mechanically ventilated adults with COVID-19 and ARDS, use low tidal volume (Vt) ventilation
(Vt 4-8mL/kg of predicted body weight), over higher tidal volumes (Vt>8mL/kg). Strong

For mechanically ventilated adults with COVID-19 and moderate to severe ARDS, use a higher PEEP
strategy, over a lower PEEP strategy. Remarks: If using a higher PEEP strategy (i.e., PEEP > 10cm
H2O), clinicians should monitor patients for barotrauma. Strong
Mechanical Ventilation for COVID-
19 Patient-Pressures and Recruitment
Maneuvers
Criteria for ventilatory support
Parameter Ventilation is No vent.
indicated
1. pulmonary function:
RR/min. < 35 10-20
Tidal volume >5 6-8
Vital capacity (mL/kg BW) > 15 65-75
Maximum inspiratory force (cm H2O) > - 20- 75-100
Parameter Ventilation is indicated No vent.

2. ABGs

PH > 7.25 7.35-7.45

PaO2 (mmHg) > 60 75-100

PaCO2 <50 35-45


Why do we care?
• Ventilators… may save lives
• BUT…..
Infections occur
Baro truam
Volutrauma
atelectrauma
Basic concepts

Oxygenation- O2 delivery Ventilation- CO2 clearance


FIO2 Tidal Volume
PEEP Minute volume
Mean airway pressure RR

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