Professional Documents
Culture Documents
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How Does Radiation
Damage Occur?
The single However, the
strand double strand
break (left) break (right)
can be means that
easily the sequence
patched up – is split into
the DNA two and it’s
helix is still not possible
held in one to stitch
piece. them back
together.
Damage and Recovery
Single-strand breaks
• Most DNA damage is
repaired, with no long-term
effects
Double-strand breaks
• Not as easily repaired, more
potential for long-term damage
• Comparatively rare (about 1
DSB to 25 SSB)
Cellular Effects of Radiation:
Free Radical Formation
Direct Effect of Radiation on Cells
Ionization and excitation of intracellular water
molecules produces free radicals
2. Indirect Action:
Radiation ionizes water,
which causes free
radicals to form. Free
radicals attack targets
such as DNA. Much
more common.
Possible Effects to Cells
Human Cells
Reproduces Replaced
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Linear No Threshold (LNT)
Hypothesis
Linear No Threshold (LNT)
Hypothesis
Linear No Threshold (LNT)
Hypothesis
Linear No Threshold (LNT)
Hypothesis
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Linear with Threshold
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Radiation Hormesis
CATEGORIES OF RISK
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Occupational Risks
Miners face an acute risk of being buried
in collapsing tunnels and a chronic risk of
contracting respiratory diseases.
Long-distance truck drivers are exposed to
an acute risk of highway accidents.
Factory workers are exposed to chemicals
and dust and have a chronic risk of ill-
health from long hours of working.
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ACUTE RADIATION RISK
The acute radiation risk in the nuclear
power industry is very low.
Fatality rate from industrial accidents in
the western world i.e., 7 per 100 million
man-hours worked.
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CHRONIC RADIATION RISK
The accepted value of the radiation risk
for Radiological Workers is 4% per 1 Sv.
i.e., a radiation dose of one Sievert, will
have an extra 4% chance of contracting a
fatal cancer.
One in every four people (25%) die of
cancer anyway.
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HOURLY RISK
Hourly radiation risk is 0.04 of one chance
in a million or 25 hours of work gives you a
one in a million risk of contracting a fatal
cancer.
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Daily Risk
Multiply the hourly radiation risk by 8, the
number of hours worked.
We get 8 x 0.04x10-6 = 0.32x10-6 for working an
eight hour day.
The fatal traffic accident risk connected with
driving 40 miles to work and 40 miles back home
is 3.2x10-6.
This means that travelling to and from work
each day is ten times as risky as the radiation
hazards you are likely to face once you get
there.
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Risk Comparisons
- increasing the risk of death by one in a million
Living 2 months in an average stone or brick house Cancer from natural radioactivity
Living 20 years near a PVC plant Cancer from vinyl chloride (1976 standard)
Living 1.5 years at site boundary of a typical NPP Cancer caused by radiation
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