Professional Documents
Culture Documents
System
Cognitive Neuroscience
David Eagleman
Jonathan Downar
Chapter Outline
Muscles
The Spinal Cord
The Cerebellum
The Motor Cortex
The Prefrontal Cortex
Basal Ganglia
Medial and Lateral Motor Systems
Did I Really Do That?
2
Muscles
Skeletal Muscle: Structure and Function
The Neuromuscular Junction
3
Skeletal Muscle: Structure and
Function
Bringing about movement is the ultimate
goal of the brain.
Muscles attach to the skeleton at the origin
and insertion.
Muscles are collections of many muscle
fibers.
4
Skeletal Muscle: Structure and
Function
5
Skeletal Muscle: Structure and
Function
Muscle spindles and Golgi tendon organs
provide proprioceptive information from
the muscles.
Muscles are organized into antagonistic
pairs, with extensors extending the joint
and flexors contract the joint.
6
The Neuromuscular Junction
Motor neurons release neurotransmitters
to cause muscle contraction at the
neuromuscular junction.
The neurotransmitter acetylcholine binds
to ionotropic receptors, causing
depolarization.
If there is enough localized depolarization,
voltage-gated ion channels will open.
7
The Neuromuscular Junction
The rapid depolarization caused by the
opening of voltage-gated ion channels
causes the release of calcium.
Calcium inside the muscle causes actin
and myosin proteins to interact, which
brings about a muscle contraction.
Acetylcholinesterase removes the
neurotransmitter and ends the contraction.
8
The Neuromuscular Junction
9
The Spinal Cord
Lower Motor Neurons
Spinal Motor Circuits: Reflexes
Spinal Motor Circuits: Central Pattern
Generators
Descending Pathways of Motor Control
10
Lower Motor Neurons
Lower motor neurons project from the
ventral horn of the spinal cord.
Alpha motor neurons cause contraction of the
skeletal muscles.
Gamma motor neurons adjust the tension in
the muscle spindle fibers so they can
accurately detect a stretch.
The motor unit is the alpha motor neuron
and all the muscle fibers it innervates.
11
Lower Motor Neurons
12
Spinal Motor Circuits: Reflexes
Reflexes are simple movements
coordinated by the spinal cord.
Proprioceptors detect a stretch and trigger
a motor response to counteract the
stretch.
The deep tendon reflex, or knee-jerk
reflex, is an example of this.
13
Spinal Motor Circuits: Reflexes
14
Spinal Motor Circuits: Central
Pattern Generators
Neurons within the spinal cord influence
rhythmic behaviors, such as walking.
Excitatory interneurons stimulate alpha motor
neurons to cause a muscle contraction.
Inhibitory interneurons are also stimulated,
eventually overwhelming the excitation.
After a period of inactivity, excitation resumes.
Inhibitory interneurons cross the midline,
causing alternating contraction and relaxation.
15
Spinal Motor Circuits: Central
Pattern Generators
16
Descending Pathways of Motor
Control
Upper motor neurons from the primary
motor cortex project to the spinal cord.
About 80% of the axons of the upper
motor neurons decussate at the medulla,
forming the lateral corticospinal tract.
About 10% decussate at the point where
they exit the spinal cord.
The remainder remain ipsilateral.
17
Descending Pathways of Motor
Control
18
Descending Pathways of Motor
Control
Other descending pathways also influence
movement.
The rubrospinal tract influences the limbs.
The vestibulospinal tract influences balance of
the trunk.
The tectospinal tract coordinates movements
to capture or avoid targets.
The reticulospinal tract coordinates startle and
escape reflexes.
19
Descending Pathways of Motor
Control
20
The Cerebellum
The Circuitry of the Cerebellum
Motor Functions of the Cerebellum
Nonmotor Functions of the Cerebellum
21
The Circuitry of the Cerebellum
The cerebellum is important for motor
coordination.
Injury to the cerebellum results in
impairments to the coordination, accuracy,
and timing of movements.
22
The Circuitry of the Cerebellum
There are three cellular layers of the
cerebellum
Granule cell layer
Purkinje cell layer
Molecular cell layer
23
The Circuitry of the Cerebellum
24
The Circuitry of the Cerebellum
Purkinje cells generate the output of the
cerebellum via inhibitory projections to
deep cerebellar nuclei.
These nuclei send excitatory connections
to the brain and spinal cord.
25
The Circuitry of the Cerebellum
Mossy fibers send excitatory input to the
granule cells, which excite the molecular
cell layer.
Climbing fibers project from the olivary
nuclei to provide excitatory input to the
Purkinje cell bodies.
Basket cells and stellate cells provide
lateral inhibitory connections.
26
Motor Functions of the
Cerebellum
Cerebellum may provide forward modeling
to fine-tune motor control.
It combines sensory and motor information
to predict where an object will be at some
future point in time.
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Motor Functions of the
Cerebellum
28
Nonmotor Functions of the
Cerebellum
The cerebellum sends projections to the
frontal lobe and influences cognition,
emotion, motivation and judgement.
Damage to the cerebellum impairs
cognition, language perception, and
grammar.
29
The Motor Cortex
Motor Cortex: Neural Coding of
Movements
Motor Cortex: Recent Controversies
30
Motor Cortex: Neural Coding of
Movements
The primary motor cortex (M1) is in the
frontal lobe, immediately anterior to the
central sulcus.
There is a motor homunculus in M1,
similar to the somatosensory homunculus
found in S1.
Areas with more motor control or sensory
input are larger in the homunculus.
31
Motor Cortex: Neural Coding of
Movements
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Motor Cortex: Neural Coding of
Movements
The lateral premotor area, supplementary
motor area, and pre-supplementary motor
area are anterior to M1.
These are motor planning areas and each
have their own somatotopic map.
33
Motor Cortex: Neural Coding of
Movements
34
Motor Cortex: Neural Coding of
Movements
The upper motor neurons of M1 project to
the lower motor neurons via the
corticospinal tracts.
They also connect with the interneurons of
the spinal cord to influence reflexes and
central pattern generators.
M1 seems to use population coding to
encode direction of movement.
35
Motor Cortex: Neural Coding of
Movements
36
Motor Cortex: Recent
Controversies
Newer research with longer stimulation of
M1 suggests the map may be more
complex than the homunculus.
Longer stimulation evokes complete
movements, like moving the hand to the
mouth and opening the mouth.
There is no obvious population coding of
direction with longer stimulation.
37
Motor Cortex: Recent
Controversies
38
The Prefrontal Cortex: Goals to
Strategies to Tactics to Actions
The Functional Organization of the
Prefrontal Cortex in Motor Control
Sensory Feedback
Mirror Neurons in Premotor Cortex
Control Stages of the Motor Hierarchy
39
The Functional Organization of
the Prefrontal Cortex
Actions are the body’s way of transforming
needs into goals and then into behaviors.
Primary motor cortex and premotor cortex
have direct connections to spinal cord to
influence movement.
Prefrontal cortical areas influence M1 and
the premotor cortex, not the spinal cord
directly.
40
The Functional Organization of
the Prefrontal Cortex
41
The Functional Organization of
the Prefrontal Cortex
Most motor areas receive extensive input
from somatosensory areas.
The frontopolar cortex receives no sensory
input and connects with other prefrontal
areas.
This helps set and maintain long-term
goals.
42
Sensory Feedback
Tactile, proprioceptive, and nociceptive
somatosensory feedback helps guide
movements.
The intraparietal sulcus contains several
areas that represent the location of objects
in space in relation to different parts of the
body.
43
Sensory Feedback
44
Mirror Neurons in Premotor
Cortex
Mirror neurons are active when performing
an action or when observing another
individual perform a similar action.
Mirror neurons are found in the ventral
premotor cortex.
45
Mirror Neurons in Premotor
Cortex
The action must be goal-directed to cause
motor neurons to fire.
These neurons may be important for our
ability to understand the thoughts and
feelings of others.
46
Mirror Neurons in Premotor
Cortex
47
Control Stages of the Motor
Hierarchy
Posterior lateral premotor areas select
actions based on sensory input.
Intermediate lateral premotor areas
choose which sensory rules to use in the
current context.
Anterior lateral premotor areas select the
appropriate context of choosing an action.
Most anterior areas keep track of overall
goals. 48
Control Stages of the Motor
Hierarchy
49
Basal Ganglia
Components of the Basal Ganglia
Circuitry of the Basal Ganglia
Diseases of the Basal Ganglia
50
Components of the Basal
Ganglia
The basal ganglia project to areas
involved in motor control, cognition, and
judgement.
The basal ganglia are gray matter
structures deep within the white matter.
The basal ganglia initiate and maintain
activity in the cortex.
51
Components of the Basal
Ganglia
There are three components of the basal
ganglia.
Striatum
Caudate
Putamen
Globus Pallidus
The subthalamic nucleus and the
substantia nigra are functionally connected
to the basal ganglia.
52
Components of the Basal
Ganglia
53
Circuitry of the Basal Ganglia
Every area of the cortex interacts with the
basal ganglia via recursive loop circuits.
There are at least five distinct loops.
Motor loop
Oculomotor loop
Dorsolateral prefrontal loop
Lateral orbitofrontal loop
Other loops and open circuits also exist.
54
Circuitry of the Basal Ganglia
There are two main pathways within the
basal ganglia.
Indirectpathway is inhibitory.
Direct pathway is excitatory.
These pathways modulate cortical activity.
55
Circuitry of the Basal Ganglia
56
Diseases of the Basal Ganglia
Huntington’s Disease
A neurodegenerative disease caused by a
dominant genetic mutation.
The gene produces huntingtin, and the altered
form is toxic to the caudate and putamen.
Patients display nonvoluntary rhythmic
movements, called chorea.
The disease progresses to dementia with
psychiatric symptoms.
57
Diseases of the Basal Ganglia
58
Diseases of the Basal Ganglia
Parkinson’s Disease
Caused by progressive destruction of the
dopaminergic neurons of the substantia nigra.
The indirect pathway (inhibitory) becomes
more active, decreasing excitation to the
thalamus and cortex.
Symptoms include slow movements and
difficulty initiating movements.
Treatments involve stimulating dopamine
receptors.
59
Medial and Lateral Motor
Systems
Organization of Medial Motor Areas
Functions of Medial and Lateral Motor
Systems
60
Organization of Medial Motor
Areas
The medial motor system controls
movements guided by internal motivations.
The supplementary motor area and pre-
supplementary motor are part of the
medial motor system.
Activity in the pre-supplementary motor
area begins several seconds before self-
initiated movements.
61
Functions of Medial and Lateral
Motor Systems
62
Functions of Medial and Lateral
Motor Systems
The lateral motor system controls
movements guided by external cues.
The medial motor system becomes more
active when internal signals are needed to
select the appropriate action.
Damage to the medial motor system
results in a lack of spontaneous behavior
and excessive externally-driven behavior.
63
Functions of Medial and Lateral
Motor Systems
64
Did I Really Do That? The
Neuroscience of Free Will
Research has tried to identify the brain
regions associated with planning a
movement.
The intent to move occurred about 200
msec before the movement.
There was activity in the frontopolar cortex
8 – 10 seconds before the movement.
What is the role of free will?
65
Did I Really Do That? The
Neuroscience of Free Will
66