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Submucosa
Muscularis
Mucosa
Externa
Muscularis
Adventitia / Serosa mucosa
Gastric-Esophageal Junction
(Esophagogastric junction)
Stomach
• Anatomically and histologically divided into
cardia, fundus body, and pylorus
– Cardia: first section; separate from esophagus by
cardiac sphincter. Glands contain mucus-secreting
cells, stem cells, enterendocrine, and occasional
parietal cells
– Fundus and body: largest portion. Fundic glands
contain parietal cells and chief cells with some stem
cells, mucous cells and enteroendocrine cells
– Pyloric region: lower end that connects to
duodenum; ends at pyloric sphincter. Glands primarily
mucus-secreting cells and two special endocrine cells:
gastrin-secreting (G cells) and somatostatin-secreting
cells (D-cells)
Mucosa of the Stomach
Columnar Epithelium
Gastric Pit
Fundic Mucosa Parietal Cells :
secrete HCL
Fundic Gland
Mucosa
Goblet
Cells
Ileum
Paneth
Cells
Peyers patches
Small Intestine: Paneth Cells
Small Intestine
Large Intestine
• Major site of absorption of water and salts
• Mucosa: No villi, gland of Lieberkuhn with many goblet cells and no
paneth cells.
• Submucosa: no glands
• Muscularis externa: Inner circular muscle plus outer longitudinal
muscle with myenteric (Auerbach) plexus between.
– Outer longitudinal muscle creates three narrow bands called tenia
coli.
• Four anatomic sections
– Cecum :
– Appendix
– Colon
– Rectum and anal canal
Large Intestine Mucosa
Goblet
Cells
Colon Wall
Muscularis externa
Mucosa
(circular portion)
Submucosa
Muscularis Externa
Appendix
Lymphatic
Nodules
Anal -Rectal Junction
Exocrine Pancreas
• Many serous secretory cells (pancreatic acinar
cells) form acinar structures.
– Cytoplasm contains zymogen granules
• Secretions carried by main duct to join bile
duct at the ampulla in the duodenum
Main pancreatic duct and surrounding acini